Korean J Nephrol.
2011 Mar;30(2):211-214.
A Case of Baclofen-Induced Encephalopathy in a Patient with ESRD on Continuous Ambulatory Peritoneal Dialysis
- Affiliations
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- 1Department of Internal Medicine, College of Medicine, Yonsei University, seoul, Korea. Yoosy0316@yuhs.ac
Abstract
- Baclofen (beta-4-chlorophenyl-gamma-aminobutyric acid), a gamma-aminobutyric acid (GABA) derivative, is commonly used for relief of spinal-origin spasm or pain. Baclofen is eliminated predominantly by the kidneys, putting patients with impaired renal function at particular risk for baclofen accumulation. The authors report on a case of baclofen-induced encephalopathy in a patient on continuous ambulatory peritoneal dialysis (CAPD). A 56 year old patient with ESRD on CAPD was admitted due to stuporous mental status after baclofen treatment. Brain imaging showed no specific abnormality. After intensive treatment of CAPD for 3 days, neurologic abnormality was completely recovered. Baclofen should not be recommended for patients with renal dysfunction. Although the best-known treatment choice for baclofen toxicity is hemodialysis, intensive CAPD can also be considered as an option for treatment of baclofen toxicity.
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