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Trefoil Factor 1 Suppresses Epithelial-mesenchymal Transition through Inhibition of TGF-beta Signaling in Gastric Cancer Cells

Lee DY, Song MY, Kim EH

Gastric cancer is a malignancy with high incidence and mortality worldwide. In gastric cancer, epithelial-mesenchymal transition (EMT) and metastasis further increase the mortality rate. Trefoil factor 1 (TFF1) has been...
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Revised Korean Antiviral Guideline Reduces the Hepatitis B-related Hepatocellular Carcinoma Risk in Cirrhotic Patients

Kim DS, Park SY, Kim BK, Park JY, Kim DY, Han KH, Lee YR, Tak WY, Kweon YO, Jung I, Han M, Kim EH, Ahn SH, Kim SU

Background: Since September 2015, the initiation of antiviral therapy (AVT) for patients with chronic hepatitis B (CHB)-related cirrhosis has been reimbursed according to the revised Korean Association for the Study...
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Delayed Hyponatremia after Transsphenoidal Surgery for Pituitary Adenomas: A Single Institutional Experience

Hong YG, Kim SH, Kim EH

Background Hyponatremia is a common complication after transsphenoidal surgery (TSS) for pituitary adenomas. This study retrospectively reviewed various clinical factors of pituitary adenoma patients who underwent TSS and aimed to...
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Heregulin-β1 Activates NF-E2-related Factor 2 and Induces Manganese Superoxide Dismutase Expression in Human Breast Cancer Cells via Protein Kinase B and Extracellular Signal-regulated Protein Kinase Signaling Pathways

Park JY, Saeidi S, Kim EH, Kim DH, Na HK, Keum JS, Surh YJ

Heregulin-β1, a ligand of ErbB-2 and ErbB-3/4 receptors, has been reported to potentiate oncogenicity and metastatic potential of breast cancer cells. In the present work, treatment of human mammary cancer...
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Sneezing and Rubbing Counts in Allergic Rhinitis Mouse Models Are a Reliable Indicator of Type 2 Immune Response

Ryu G, Bae JS, Kim JH, Kim EH, Chung YJ, Mo JH

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Pharmacokinetics and bioequivalence of fixed-dose combination of candesartan cilexetil/amlodipine besylate (16/10 mg) versus coadministration of individual formulations in healthy subjects

Lee HW, Kang WY, Jung W, Gwon MR, Yang DH, Kim EH, Cho K, Yoon YR, Seong SJ

This study compared the pharmacokinetics of a fixed-dose combination (FDC) of candesartan (16 mg) and amlodipine (10 mg) versus coadministration of individual formulations to clarify the bioequivalence of the FDC....
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Common data model-based real-world data for practical clinical practice guidelines: clinical pharmacology perspectives

Jeon Y, Choi Y, Kim EH, Oh S, Lee H

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A Systematic Review of Workplace Interventions for the Mental Health of Workers

Lee YJ, Kim EH

Purpose: The purpose of this study was to review workplace interventions for mental health among workers. Methods: A systematic literature search was conducted using the PubMed, EMBASE, PsycINFO, and CINAHL...
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Analysis of Tumor Size between Imaging of Preoperative Ultrasound, MRI and Pathologic Measurements in Early Breast Carcinoma

Kim EH, Park CG, Choi EH, Kim YJ, Kim MJ, Han KD, Park YS, Kim CS, No KH, Yu EA, Na GG

Purpose: Preoperative tumor size is associated with clinical stage, treatment plan and even survival rate of patient. We investigated the accuracy of tumor size estimation between magnetic resonance imaging (MRI)...
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Role of IL-17A in Chronic Rhinosinusitis With Nasal Polyp

Ryu G, Bae JS, Kim JH, Kim EH, Lyu L, Chung YJ, Mo JH

PURPOSE: Th17-associated inflammation is increased in chronic rhinosinusitis with nasal polyp (CRSwNP), and is associated with disease severity and steroid resistance. Overexpressed interleukin (IL)-17A affects CRSwNP by tissue remodeling, eosinophilic...
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Clinical performance of Ambu AuraGainTM versus i-gelTM in anesthetized children: a prospective, randomized controlled trial

Lee JH, Nam S, Jang YE, Kim EH, Kim HS, Kim JT

Background: Ambu AuraGain and i-gel have different characteristics in design each other. However, few reports evaluate which device has more benefits for ventilation in children undergoing paralyzed general anesthesia. This...
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Analysis of Risk Factors for Myringosclerosis Formation after Ventilation Tube Insertion

Kim EH, Park KW, Lee SH, Kim BJ, Park YH

Background This study examined possible risk factors for myringosclerosis formation after ventilation tube insertion (VTI). Methods A retrospective study was performed in a single tertiary referral center. A total of 582 patients who...
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Cytotoxicity of natural killer cells on canine mammary carcinoma cells

Jeong DU, Byeon JS, Gu NY, Jung M, Kim EH, Kim HS, Cho IS, Song JY, Hyun BH, Lee J

Natural killer (NK) cells play have a crucial role in the early phase of immune responses against various pathogens. We compared characteristics of canine NK cells against two canine mammary...
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Neonatal Outcomes in Term Births according to Gestational Weeks

Park YJ, Kwak YH, Kim HY, Han SW, Kim EH

Objective This study aimed to determine neonatal outcomes and morbidities according to gestational weeks in term births. Methods This was a retrospective observational study of 626 singleton deliveries from 37 0/7 to 41...
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External Validation of a Pharmacokinetic Model of Propofol for Target-Controlled Infusion in Children under Two Years Old

Ji SH, Lee JH, Cho JY, Kim HS, Jang YE, Kim EH, Kim JT, Kim HS

BACKGROUND: Previously, a linked pharmacokinetic-pharmacodynamic model (the Kim model) of propofol with concurrent infusion of remifentanil was developed for children aged 2–12 years. There are few options for pharmacokinetic-pharmacodynamic model...
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Association between Serum Free Thyroxine and Anemia in Euthyroid Adults: A Nationwide Study

Kim M, Kim BH, Lee H, Jang MH, Kim JM, Kim EH, Jeon YK, Kim SS, Kim IJ

BACKGROUND: Studies on the relationship between thyroid function and anemia in the euthyroid range are scarce. We aimed to evaluate the association between anemia and serum free thyroxine (fT4) and...
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Adrenocorticotropic Hormone-Secreting Esthesioneuroblastoma with Ectopic Cushing's Syndrome

Chung YS, Na M, Ku CR, Kim SH, Kim EH

Esthesioneuroblastoma as a source of ectopic Cushing's syndrome is rare, and to the best of our knowledge, only 20 cases have been reported worldwide. A 46-year-old healthy man visited a...
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Altered Structural Network in Newly Onset Childhood Absence Epilepsy

Kim EH, Shim WH, Lee JS, Yoon HM, Ko TS, Yum MS

Background and Purpose: Recent quantitative neuroimaging studies of childhood absence epilepsy (CAE) have identified various structural abnormalities that might be involved in the onset of absence seizure and associated cognitive...
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Glioblastoma Cellular Origin and the Firework Pattern of Cancer Genesis from the Subventricular Zone

Yoon SJ, Park J, Jang DS, Kim HJ, Lee JH, Jo E, Choi RJ, Shim JK, Moon JH, Kim EH, Chang JH, Lee JH, Kang SG

Glioblastoma (GBM) is a disease without any definite cure. Numerous approaches have been tested in efforts to conquer this brain disease, but patients invariably experience recurrence or develop resistance to...
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Diels-Alder Type Adducts from Hairy Root Cultures of Morus macroura

Happyana N, Hakim EH, Syah YM, Kayser O, Juliawaty , Mujahidin , Ermayanti , Achmad SA

Three Diels-Alder type adducts, guangsangon E (1), chalcomoracin (2) and sorocein I (3) were isolated from hairy root cultures of Morus macroura. The structures of the isolated compounds (1 –...
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