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Subtypes of Sleep Disturbance in Parkinson's Disease Based on the Cross-Culturally Validated Korean Version of Parkinson's Disease Sleep Scale-2

Yang HJ, Kim HJ, Koh SB, Kim JS, Ahn TB, Cheon SM, Cho JW, Kim YJ, Ma HI, Park MY, Baik JS, Lee PH, Chung SJ, Kim JM, Song IU, Kim JY, Sung YH, Kwon DY, Lee JH, Lee JY, Kim JS, Yun JY, Kim HJ, Hong JY, Kim MJ, Youn J, Kim JS, Oh ES, Yoon WT, You S, Kwon KY, Park HE, Lee SY, Kim Y, Kim HT, Kim SJ

BACKGROUND AND PURPOSE: This study aimed to determine the clinimetric properties of the Korean version of Parkinson's Disease Sleep Scale-2 (K-PDSS-2) and whether distinct subtypes of sleep disturbance can be...
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Benefits of Levodopa-Carbidopa Intestinal Gel Infusion in Patients with Parkinson's Disease Experiencing Gait Dysfunction Following Subthalamic Deep Brain Stimulation

Kimber TE, Zhuang Y, Thompson P

No abstract available.
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The Impact of Impulsivity on Quality of Life in Early Drug-Naïve Parkinson's Disease Patients

Ryu DW, Kim JS, Yoo SW, Oh YS, Lee KS

OBJECTIVE: Impulse control disorders (ICDs) in Parkinson's disease (PD) are mostly related to dopamine replacement therapy (DRT); however, drug-naïve PD patients have also frequently experienced impulsivity. This phenomenon makes clinicians...
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Oro-Pharyngeal Dysphagia in Parkinson's Disease and Related Movement Disorders

Kwon M, Lee JH

Oro-pharyngeal dysphagia is a common symptom in patients with Parkinson's disease (PD) and related disorders, even in their early stage of diseases. Dysphagia in these patients has been underdiagnosed, probably...
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Urodynamic Mechanisms Underlying Overactive Bladder Symptoms in Patients With Parkinson Disease

Vurture G, Peyronnet , Palma JA, Sussman RD, Malacarne , Feigin A, Palmerola , Rosenblum , Frucht S, Kaufmann H, Nitti VW, Brucker BM

PURPOSE: To assess the urodynamic findings in patients with Parkinson disease (PD) with overactive bladder symptoms. METHODS: We performed a retrospective chart review of all PD patients who were seen in...
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Spatiotemporal Gait Parameter Comparison for Parkinson's Disease, Multiple System Atrophy, and Other Parkinsonism Diseases

Bae CH, Jeong HW, Yun JY, Lee JE, Han SJ

The aim of this study was to compare and quantify the spatiotemporal and gait parameters obtained by foot pressure analysis during the gait in a group of Parkinson's disease (PD)...
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Effects of the Team Approach Rehabilitation Program on Balance, Gait, and Muscle Strength of Lower Extremities for Elderly Patients with Parkinson's Disease

Choi JY, Jo HS

PURPOSE: The purpose of this paper was to verify effects of the team approach rehabilitation program on balance, gait, and muscle strength of lower extremities of elderly people with Parkinson's...
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Parkinson's Disease: The Emerging Role of Gut Dysbiosis, Antibiotics, Probiotics, and Fecal Microbiota Transplantation

Dutta SK, Verma S, Jain V, Surapaneni BK, Vinayek R, Phillips L, Nair PP

  • KMID: 2454635
  • J Neurogastroenterol Motil.
  • 2019 Jul;25(3):363-376.
  • doi: 10.5056/jnm19044
The role of the microbiome in health and human disease has emerged at the forefront of medicine in the 21st century. Over the last 2 decades evidence has emerged to...
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Restless Legs Syndrome in Parkinson's Disease Patients: Clinical Features Including Motor and Nonmotor Symptoms

You S, Jeon SM, Do SY, Cho YW

BACKGROUND AND PURPOSE: We investigated the frequency and clinical features of restless legs syndrome (RLS) in patients with Parkinson's disease (PD). METHODS: This study included 74 PD patients. RLS was diagnosed...
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Abnormal Mitochondria in a Non-human Primate Model of MPTP-induced Parkinson's Disease: Drp1 and CDK5/p25 Signaling

Park J, Seo J, Won J, Yeo HG, Ahn YJ, Kim K, Jin YB, Koo BS, Lim KS, Jeong KJ, Kang P, Lee HY, Baek SH, Jeon CY, Hong JJ, Huh JW, Kim YH, Park SJ, Kim SU, Lee DS, Lee SR, Lee Y

Mitochondria continuously fuse and divide to maintain homeostasis. An impairment in the balance between the fusion and fission processes can trigger mitochondrial dysfunction. Accumulating evidence suggests that mitochondrial dysfunction is...
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Heterogeneous Patterns of Striatal Dopamine Loss in Patients with Young- versus Old-Onset Parkinson's Disease: Impact on Clinical Features

Chung SJ, Yoo HS, Lee YH, Lee PH, Sohn YH

OBJECTIVE: Ample evidence has suggested that age at onset of Parkinson's disease (PD) is associated with heterogeneous clinical features in individuals. We hypothesized that this may be attributed to different...
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Characterization of Vitamin B12 Supplementation and Correlation with Clinical Outcomes in a Large Longitudinal Study of Early Parkinson's Disease

Dietiker C, Kim S, Zhang Y, Christine , on behalf of the NINDS NET-PD Investigators

OBJECTIVE: In Parkinson's disease (PD), vitamin B12 levels are lower, and comorbid B12 deficiency has been associated with the development of neuropathy and early gait instability. Because little is known...
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Asymptomatic Hearing Impairment Frequently Occurs in Early-Onset Parkinson's Disease

Shetty K, Krishnan S, Thulaseedharan JV, Mohan M, Kishore A

OBJECTIVE: Recent reports of hearing impairment in Parkinson's disease (PD) have suggested that auditory dysfunction could be a non-motor manifestation of PD. These reports were based on observations of elderly...
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Altered Gut Microbiome and Intestinal Pathology in Parkinson's Disease

Chiang HL, Lin CH

Parkinson's disease (PD) is a common neurodegenerative disorder arising from an interplay between genetic and environmental risk factors. Studies have suggested that the pathological hallmarks of intraneuronal α-synuclein aggregations may...
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Characteristics of Smell Identification Test in Patients With Parkinson Disease

Fujio H, Inokuchi G, Tatehara S, Kuroki S, Fukuda Y, Kowa H, Nibu KI

OBJECTIVES: Parkinson disease (PD) is frequently associated with olfactory disorder at early stage, which is caused by deposition of Lewy bodies emerging from the olfactory bulb to higher olfactory centers....
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Can Olfactory Tests Help to Diagnose Parkinson Disease?

Kim JK

No abstract available.
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Effects of Sagittal Spinopelvic Alignment on Motor Symptom and Respiratory Function in Mild to Moderate Parkinson's disease

Kang D, Cheon S, Son M, Sung H, Lee H

PURPOSE: This study examined the effects of sagittal spinopelvic alignment on the clinical parameters, motor symptoms, and respiratory function in patients with mild to moderate Parkinson's disease (PD). METHODS: This study...
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Caregiver Burden and Quality of Life in Early and Late Stages of Idiopathic Parkinson's Disease

Genç F, Yuksel B, Tokuc FE

OBJECTIVE: Idiopathic Parkinson's disease (IPD) is a chronic progressive neurodegenerative movement disorder characterized by motor and non-motor symptoms that affects patients’ quality of life and caregiver burden. The aim of...
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CRISPR/Cas9 Edited sRAGE-MSCs Protect Neuronal Death in Parkinson's Disease Model

Lee J, Bayarsaikhan D, Arivazhagan R, Park H, Lim B, Gwak P, Jeong GB, Lee J, Byun K, Lee B

BACKGROUND AND OBJECTIVES: Parkinson’s disease (PD) is a fatal and progressive degenerative disease of the nervous system. Until recently, its promising treatment and underlying mechanisms for neuronal death are poorly...
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The History of Parkinson's Disease and Famous Patients

Kim KT, You S

BACKGROUND: Parkinson's disease (PD) is one of the most common neurodegenerative diseases. However, the history of PD and famous persons with PD have not been described in detail yet. METHODS: We...
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