Korean J Psychopharmacol.  2008 Jan;19(1):29-37.

Genes Causing Familial Parkinson's Disease

• Seol W

Abstract

Extended treatment using specific medicines for Parkinson's disease (PD) or psychotic disorders often induces symptoms related to psychotic disorders or PD, respectively. PD is the second most common neurodegenerative disease. Most cases of PD occur sporadically, but approximately 5-10% of cases are inherited as familial PD (FPD). Identification of the genes responsible for FPD, as well as their function, is essential to clarify the pathogenic mechanism of PD. Recent genomic analyses using samples obtained from patients with FPD have mapped 13 PARK loci and have identified SNCA, LRRK2, parkin, PINK1, DJ-1, ATP13A2 and UCHL1 as genes causing PD in those loci. This review discusses the results of recent studies on these PD genes.

Keyword

Parkinson's disease; Parkinsonism genes; Familial Parkinson's disease

MeSH Terms

Humans
Neurodegenerative Diseases
Parkinson Disease
Psychotic Disorders