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Effect of Coffee, Tobacco, and Alcohol on Parkinson’s Disease

Seol W, Kim H, Son I

Since the neuroprotective effects of coffee and tobacco on Parkinson’s disease have been reported more than 50 years ago, clinical studies using caffeine and nicotine that were presumed as effective...
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Ciliogenesis is Not Directly Regulated by LRRK2 Kinase Activity in Neurons

Kim H, Sim H, Lee JE, Seo MK, Lim J, Bang Y, Nam D, Lee SY, Chung SK, Choi HJ, Park SW, Son I, Kim J, Seol W

  • KMID: 2517476
  • Exp Neurobiol.
  • 2021 Jun;30(3):232-243.
  • doi: 10.5607/en21003
Mutations in the Leucine-rich repeat kinase 2 (LRRK2 ) gene are the most prevalent cause of familial Parkinson’s disease (PD). The increase in LRRK2 kinase activity observed in the pathogenic...
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Rab GTPases as Physiological Substrates of LRRK2 Kinase

Seol W, Nam D, Son I

LRRK2 (Leucine-Rich Repeat Kinase 2) is a gene whose specific mutations cause Parkinson's disease (PD), the most common neurodegenerative movement disorder. LRRK2 harbors GTPase and kinase activities, two enzyme activities...
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LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation

Ho DH, Je AR, Lee H, Son I, Kweon HS, Kim HG, Seol W

Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease (PD). LRRK2 contains a functional kinase domain and G2019S, the most prevalent LRRK2 pathogenic mutation,...
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Extracellular Vesicles and Neurological Diseases

Ho DH, Seo H, Son I, Seol W

Extracellular vesicles (EVs) are small membranous vesicles that are secreted by various types of cells into biofluid or culture medium. EVs contain deoxyribonucleic acids, messenger ribonucleic acids (RNAs), microRNAs, lipids,...
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The Role of Autophagy Associated With Causative Genes for Parkinson's Disease

Ho DH, Seo H, Son I, Seol W

  • KMID: 2343520
  • J Korean Neurol Assoc.
  • 2014 Aug;32(3):137-144.
Parkinson's disease (PD) is the second most common neurodegenerative motor disorder, affecting approximately 1% of the population aged > or =60 years. Recent investigations have shown that in addition to...
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LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25

Yun HJ, Park J, Ho DH, Kim H, Kim CH, Oh H, Ga I, Seo H, Chang S, Son I, Seol W

  • KMID: 2154255
  • Exp Mol Med.
  • 2013 Aug;45(8):e36.
Leucine-rich repeat kinase 2 (LRRK2) is a gene that, upon mutation, causes autosomal-dominant familial Parkinson's disease (PD). Yeast two-hybrid screening revealed that Snapin, a SNAP-25 (synaptosomal-associated protein-25) interacting protein, interacts...
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Misfolded Proteins in Neurodegenerative Dementias: Molecular Mechanisms

Yang HD, Ho DH, Yi MJ, Seol W, Kim SY

During recent years, there has been remarkable progress with respect to the identification of molecular mechanisms and underlying pathology of neurodegenerative dementias. The latest evidence indicates that a common cause...
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Unstable Repeat Expansion in Neurodegenerative Dementias: Mechanisms of Disease

Yang HD, Ho DH, Seol W

The majority of neurodegenerative dementias are thought to result primarily from the misfolding, aggregation and accumulation of proteins which interfere with protein homeostasis in the brain. Some of them are...
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Coordinate Regulation of Neurite Outgrowth by LRRK2 and Its Interactor, Rab5

Heo HY, Kim KS, Seol W

Neurite outgrowth and its maintenance are essential aspects of neuronal cells for their connectivity and communication with other neurons. Recent studies showed that over-expression of either leucine-rich repeat kinase 2...
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Genes Causing Familial Parkinson's Disease

Seol W

  • KMID: 2287437
  • Korean J Psychopharmacol.
  • 2008 Jan;19(1):29-37.
Extended treatment using specific medicines for Parkinson's disease (PD) or psychotic disorders often induces symptoms related to psychotic disorders or PD, respectively. PD is the second most common neurodegenerative disease....
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