- Genes Causing Familial Parkinson's Disease
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Seol W
- KMID: 2287437
- Korean J Psychopharmacol.
- 2008 Jan;19(1):29-37.
Extended treatment using specific medicines for Parkinson's disease (PD) or psychotic disorders often induces symptoms related to psychotic disorders or PD, respectively. PD is the second most common neurodegenerative disease.... -
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- Effect of Coffee, Tobacco, and Alcohol on Parkinson’s Disease
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Seol W, Kim H, Son I
- KMID: 2518929
- J Korean Neurol Assoc.
- 2021 Aug;39(3):129-133.
- doi: 10.17340/jkna.2021.3.3
Since the neuroprotective effects of coffee and tobacco on Parkinson’s disease have been reported more than 50 years ago, clinical studies using caffeine and nicotine that were presumed as effective... -
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- Extracellular Vesicles and Neurological Diseases
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Ho DH, Seo H, Son I, Seol W
- KMID: 2184640
- J Korean Neurol Assoc.
- 2015 May;33(2):75-81.
- doi: 10.17340/jkna.2015.2.1
Extracellular vesicles (EVs) are small membranous vesicles that are secreted by various types of cells into biofluid or culture medium. EVs contain deoxyribonucleic acids, messenger ribonucleic acids (RNAs), microRNAs, lipids,... -
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- Coordinate Regulation of Neurite Outgrowth by LRRK2 and Its Interactor, Rab5
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Heo HY, Kim KS, Seol W
- KMID: 1460707
- Exp Neurobiol.
- 2010 Sep;19(2):97-105.
- doi: 10.5607/en.2010.19.2.97
Neurite outgrowth and its maintenance are essential aspects of neuronal cells for their connectivity and communication with other neurons. Recent studies showed that over-expression of either leucine-rich repeat kinase 2... -
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- The Role of Autophagy Associated With Causative Genes for Parkinson's Disease
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Ho DH, Seo H, Son I, Seol W
- KMID: 2343520
- J Korean Neurol Assoc.
- 2014 Aug;32(3):137-144.
Parkinson's disease (PD) is the second most common neurodegenerative motor disorder, affecting approximately 1% of the population aged > or =60 years. Recent investigations have shown that in addition to... -
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- Unstable Repeat Expansion in Neurodegenerative Dementias: Mechanisms of Disease
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Yang HD, Ho DH, Seol W
- KMID: 2172260
- Dement Neurocogn Disord.
- 2012 Mar;11(1):1-12.
- doi: 10.12779/dnd.2012.11.1.1
The majority of neurodegenerative dementias are thought to result primarily from the misfolding, aggregation and accumulation of proteins which interfere with protein homeostasis in the brain. Some of them are... -
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- Misfolded Proteins in Neurodegenerative Dementias: Molecular Mechanisms
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Yang HD, Ho DH, Yi MJ, Seol W, Kim SY
- KMID: 2172233
- Dement Neurocogn Disord.
- 2012 Jun;11(2):38-52.
- doi: 10.12779/dnd.2012.11.2.38
During recent years, there has been remarkable progress with respect to the identification of molecular mechanisms and underlying pathology of neurodegenerative dementias. The latest evidence indicates that a common cause... -
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- Rab GTPases as Physiological Substrates of LRRK2 Kinase
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Seol W, Nam D, Son I
- KMID: 2450209
- Exp Neurobiol.
- 2019 Apr;28(2):134-145.
- doi: 10.5607/en.2019.28.2.134
LRRK2 (Leucine-Rich Repeat Kinase 2) is a gene whose specific mutations cause Parkinson's disease (PD), the most common neurodegenerative movement disorder. LRRK2 harbors GTPase and kinase activities, two enzyme activities... -
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- LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation
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Ho DH, Je AR, Lee H, Son I, Kweon HS, Kim HG, Seol W
- KMID: 2416244
- Exp Neurobiol.
- 2018 Jun;27(3):171-180.
- doi: 10.5607/en.2018.27.3.171
Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease (PD). LRRK2 contains a functional kinase domain and G2019S, the most prevalent LRRK2 pathogenic mutation,... -
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- Ciliogenesis is Not Directly Regulated by LRRK2 Kinase Activity in Neurons
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Kim H, Sim H, Lee JE, Seo MK, Lim J, Bang Y, Nam D, Lee SY, Chung SK, Choi HJ, Park SW, Son I, Kim J, Seol W
- KMID: 2517476
- Exp Neurobiol.
- 2021 Jun;30(3):232-243.
- doi: 10.5607/en21003
Mutations in the Leucine-rich repeat kinase 2 (LRRK2 ) gene are the most prevalent cause of familial Parkinson’s disease (PD). The increase in LRRK2 kinase activity observed in the pathogenic... -
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- LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25
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Yun HJ, Park J, Ho DH, Kim H, Kim CH, Oh H, Ga I, Seo H, Chang S, Son I, Seol W
- KMID: 2154255
- Exp Mol Med.
- 2013 Aug;45(8):e36.
Leucine-rich repeat kinase 2 (LRRK2) is a gene that, upon mutation, causes autosomal-dominant familial Parkinson's disease (PD). Yeast two-hybrid screening revealed that Snapin, a SNAP-25 (synaptosomal-associated protein-25) interacting protein, interacts... -
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