J Korean Neurol Assoc.
2015 May;33(2):75-81. 10.17340/jkna.2015.2.1.
Extracellular Vesicles and Neurological Diseases
- Affiliations
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- 1InAm Neuroscience Research Center, Sanbon Hospital, Wonkwang University School of Medicine, Gunpo, Korea. sonih@wku.ac.kr, wseolha@gmail.com
- 2Department of Neurology, Sanbon Hospital, Wonkwang University School of Medicine, Gunpo, Korea.
- 3Department of Molecular and Life Sciences, Hanyang University, Ansan, Korea.
- KMID: 2184640
- DOI: http://doi.org/10.17340/jkna.2015.2.1
Abstract
- Extracellular vesicles (EVs) are small membranous vesicles that are secreted by various types of cells into biofluid or culture medium. EVs contain deoxyribonucleic acids, messenger ribonucleic acids (RNAs), microRNAs, lipids, and proteins derived from its cells of origin and can transfer those molecules to other targeted cells. Therefore, EVs can play important roles in intercellular communication. The findings of recent studies suggest that EVs can be used to spread protein aggregates in various neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. In addition, it has been recognized that EVs can be used as a material for detecting biomarkers for such diseases or as a therapeutic tool.
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