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Effect of Coffee, Tobacco, and Alcohol on Parkinson’s Disease

Seol W, Kim H, Son I

Since the neuroprotective effects of coffee and tobacco on Parkinson’s disease have been reported more than 50 years ago, clinical studies using caffeine and nicotine that were presumed as effective...
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Ciliogenesis is Not Directly Regulated by LRRK2 Kinase Activity in Neurons

Kim H, Sim H, Lee JE, Seo MK, Lim J, Bang Y, Nam D, Lee SY, Chung SK, Choi HJ, Park SW, Son I, Kim J, Seol W

  • KMID: 2517476
  • Exp Neurobiol.
  • 2021 Jun;30(3):232-243.
  • doi: 10.5607/en21003
Mutations in the Leucine-rich repeat kinase 2 (LRRK2 ) gene are the most prevalent cause of familial Parkinson’s disease (PD). The increase in LRRK2 kinase activity observed in the pathogenic...
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Rab GTPases as Physiological Substrates of LRRK2 Kinase

Seol W, Nam D, Son I

LRRK2 (Leucine-Rich Repeat Kinase 2) is a gene whose specific mutations cause Parkinson's disease (PD), the most common neurodegenerative movement disorder. LRRK2 harbors GTPase and kinase activities, two enzyme activities...
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Secondary Degeneration of the Ipsilateral Thalamus and Substantia Nigra Following Cerebral Infarction in the Striatum

Kim J, Kim J, Seo KD, Han S, Son I, Lee SI

Secondary degeneration after ischemic stroke has been demonstrated by computed tomography and magnetic resonance imaging. We report a 77-year-old man with striatal infarction followed by multifocal degeneration that developed in...
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LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation

Ho DH, Je AR, Lee H, Son I, Kweon HS, Kim HG, Seol W

Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease (PD). LRRK2 contains a functional kinase domain and G2019S, the most prevalent LRRK2 pathogenic mutation,...
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Isoflurane's Effect on Intraoperative Systolic Left Ventricular Performance in Cardiac Valve Surgery Patients

Kim JD, Son I, Kwon WK, Sung TY, Sidik H, Kim K, Kang H, Bang J, Yeo GE, Lee DK, Kim TY

BACKGROUND: Isoflurane, a common anesthetic for cardiac surgery, reduced myocardial contractility in many experimental studies, few studies have determined isoflurane's direct impact on the left ventricular (LV) contractile function during...
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KCHO-1, a novel herbal anti-inflammatory compound, attenuates oxidative stress in an animal model of amyotrophic lateral sclerosis

Kook MG, Choi SW, Seo Y, Kim DW, Song BK, Son I, Kim S, Kang KS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective death of motor neurons in the central nervous system. The main cause of the disease remains elusive, but several...
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Perceived Ethnic Discrimination and Depressive Symptoms Among Biethnic Adolescents in South Korea

Park GR, Son I, Kim SS

OBJECTIVES: This study investigated the association between perceived ethnic discrimination and depressive symptoms among biethnic adolescents in South Korea. METHODS: We performed a cross-sectional study of 4141 biethnic adolescents using data...
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Extracellular Vesicles and Neurological Diseases

Ho DH, Seo H, Son I, Seol W

Extracellular vesicles (EVs) are small membranous vesicles that are secreted by various types of cells into biofluid or culture medium. EVs contain deoxyribonucleic acids, messenger ribonucleic acids (RNAs), microRNAs, lipids,...
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The Role of Autophagy Associated With Causative Genes for Parkinson's Disease

Ho DH, Seo H, Son I, Seol W

  • KMID: 2343520
  • J Korean Neurol Assoc.
  • 2014 Aug;32(3):137-144.
Parkinson's disease (PD) is the second most common neurodegenerative motor disorder, affecting approximately 1% of the population aged > or =60 years. Recent investigations have shown that in addition to...
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LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25

Yun HJ, Park J, Ho DH, Kim H, Kim CH, Oh H, Ga I, Seo H, Chang S, Son I, Seol W

  • KMID: 2154255
  • Exp Mol Med.
  • 2013 Aug;45(8):e36.
Leucine-rich repeat kinase 2 (LRRK2) is a gene that, upon mutation, causes autosomal-dominant familial Parkinson's disease (PD). Yeast two-hybrid screening revealed that Snapin, a SNAP-25 (synaptosomal-associated protein-25) interacting protein, interacts...
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Nursing Needs and Satisfaction with Medications in Patients Admitted to Hospital

Yang Y, Ju H, Lim K, Park Y, Son I, Lee E

  • KMID: 2296674
  • J Korean Acad Fundam Nurs.
  • 2006 Apr;13(1):15-23.
PURPOSE: This study was done to identify the differences nursing needs and satisfaction with medications in patients admitted to hospital. METHOD: The participants were 258 patients admitted for 3days or...
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The role of Video-Urodynamic Study in the Diagnosis of Benign Prostatic Hyperplasia

Son I, Park J, Ryu J, Lee T, Suh J

PURPOSE: Benign prostatic hyperplasia (BPH) frequently combines other geriatric diseases, which affect voiding in complicated manner. However, differential diagnosis of BPH attributable to voiding dysfunction in such complicated cases has...
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The effect of the eradication of helicobater pylori in the duodenal ulcer patients upon the duodenal ulcer recurrence

Kim NY, Yoon YH, Cho YS, Chae BN, Choi CY, Lee KH, Son I, Park SH, Koo MS, Choi SE

  • KMID: 1698310
  • Korean J Med.
  • 1993 Sep;45(3):337-346.
No abstract available.
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Cold lesions in Tc-MDP bone scans of patients with skeleted metastases

Choi CW, Yang HI, Bae SK, Lee DS, Son I, Jeong JK, Lee MC, Koh CS

  • KMID: 1685942
  • Korean J Nucl Med.
  • 1993 May;27(1):98-103.
No abstract available.
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Evaluation of the effects of amlodipine on ambulatory blood pressure in hypertensive patients

Kim SY, Kim AN, Lim SH, Lim YS, Kim YK, Lee KH, Son I, Park SH

BACKGROUND: A clinical trial was performed to evaluate the antihypertensive efficacy and side effects of amlodipine, a new long-action calcium antagonist, in patients with mild to moderate essential hypertension as...
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Assessment of fibrosis in chronic hepatitis with serum collagen type IV-7S

Kim AN, Kim SY, Lim SH, Lim YS, Lee KH, Son I, Prk SH, Choi SE

  • KMID: 1696445
  • Korean J Gastroenterol.
  • 1993 Apr;25(2):345-351.
No abstract available.
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A case of left ventricular pseudoaneurysm after acute myocardial infarction

Lee JY, Sung CM, Kyeong CS, Lee SY, Kim DC, Lee KH, Choi SJ, Son I, Park SH

  • KMID: 1697914
  • Korean J Intern Med.
  • 1991 Jun;40(6):813-819.
No abstract available.
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The Effect of Lovastatin(Mevacor(R)) in Patients with Hypercholesterolemia

Lee SY, Kyoung CS, Kim DC, Lee KH, Choi SJ, Son I, Park SH

Lovastatin is a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, which catalyzes the conversion of hydroxymethylglutaryl-coenzyme A to mevalonate, anearly and rate-limiting step in the synthesis of cholesterol. We studied...
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A case of subacute necrotizing lymphadenitis with prominent enlarge-ment of the retroperitoneal lymph nodes

Kyeong CS, Kim AN, Kim SY, Lim TS, Lim SH, Lee KH, Choi SJ, Son I, Park SH, You BU, Park KJ, Choi SE

  • KMID: 1698028
  • Korean J Intern Med.
  • 1991 Dec;41(6):841-847.
No abstract available.
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