J Vet Sci.  2017 Dec;18(4):487-497. 10.4142/jvs.2017.18.4.487.

KCHO-1, a novel herbal anti-inflammatory compound, attenuates oxidative stress in an animal model of amyotrophic lateral sclerosis

Affiliations
  • 1Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea. kangpub@snu.ac.kr
  • 2Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
  • 3Center of Integrative Medicine, Department of Internal Medicine, Wonkwang University Gwangju Hospital, Wonkwang University Gwangju Medical Center, Gwangju 61729, Korea.
  • 4Department of Internal Medicine, School of Oriental Medicine, Wonkwang University, Iksan 54538, Korea.
  • 5Department of Neurology, Inam Neuroscience Research Center, Wonkwang University Sanbon Hospital, Gunpo 15865, Korea.
  • 6ALS/MND Center of Wonkwang University Korean Medical Hospital, Wonkwang University Gwangju Medical Center, Gwangju 61729, Korea. kangpub@snu.ac.kr

Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective death of motor neurons in the central nervous system. The main cause of the disease remains elusive, but several mutations have been associated with the disease process. In particular, mutant superoxide dismutase 1 (SOD1) protein causes oxidative stress by activating glia cells and contributes to motor neuron degeneration. KCHO-1, a novel herbal combination compound, contains 30% ethanol and the extracts of nine herbs that have been commonly used in traditional medicine to prevent fatigue or inflammation. In this study, we investigated whether KCHO-1 administration could reduce oxidative stress in an ALS model. KCHO-1 administered to ALS model mice improved motor function and delayed disease onset. Furthermore, KCHO-1 administration reduced oxidative stress through gp91(phox) and the MAPK pathway in both classically activated microglia and the spinal cord of hSOD1(G93A) transgenic mice. The results suggest that KCHO-1 can function as an effective therapeutic agent for ALS by reducing oxidative stress.

Keyword

amyotrophic lateral sclerosis; gp91(phox); neurodegenerative diseases; oxidative stress; traditional medicine

MeSH Terms

Amyotrophic Lateral Sclerosis*
Animals*
Central Nervous System
Ethanol
Fatigue
Inflammation
Medicine, Traditional
Mice
Mice, Transgenic
Microglia
Models, Animal*
Motor Neurons
Neurodegenerative Diseases
Neuroglia
Oxidative Stress*
Spinal Cord
Superoxide Dismutase
Ethanol
Superoxide Dismutase
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