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Oxidative Stress Modulates the Expression Pattern of Peroxiredoxin-6 in Peripheral Blood Mononuclear Cells of Asthmatic Patients and Bronchial Epithelial Cells

Shim HJ, Park SY, Kwon HS, Song WJ, Kim TB, Moon KA, Choi JP, Kim SJ, Cho YS

PURPOSE: Reduction-oxidation reaction homeostasis is vital for regulating inflammatory conditions and its dysregulation may affect the pathogenesis of chronic airway inflammatory diseases such as asthma. Peroxiredoxin-6, an important intracellular anti-oxidant...
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Inhibition of the 26S and 20S Proteasomes by the Site-specific Inhibitors

Woo KM

OBJECTIVE: The study was performed to establish the purification processes of both 26S and 20S proteasomes, also to investigate the inhibitory properties and patterns of two different proteasome inhibitors on...
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Nutlin-3 enhances the bortezomib sensitivity of p53-defective cancer cells by inducing paraptosis

Lee DM, Kim IY, Seo MJ, Kwon MR, Choi KS

The proteasome inhibitor, bortezomib, is ineffective against many solid tumors. Nutlin-3 is a potent antagonist of human homolog of murine double minute 2/p53 interaction exhibiting promising therapeutic anti-cancer activity. In...
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Effects of a Proteasome Inhibitor on Cardiomyocytes in a Pressure-Overload Hypertrophy Rat Model: An Animal Study

Kim IS, Jo WM

BACKGROUND: The ubiquitin-proteasome system (UPS) is an important pathway of proteolysis in pathologic hypertrophic cardiomyocytes. We hypothesize that MG132, a proteasome inhibitor, might prevent hypertrophic cardiomyopathy (CMP) by blocking the...
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Optimal maintenance and consolidation therapy for multiple myeloma in actual clinical practice

Lee HS, Min CK

Multiple myeloma is an incurable malignant plasma cell-originating cancer. Although its treatment outcomes have improved with the use of glucocorticoids, alkylating drugs, and novel agents, including proteasome inhibitors (bortezomib and...
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Inhibitory Effect of Apocynin on Proteasome Inhibition-Induced Apoptosis in Differentiated PC12 Cells

Kang JH, Han SW, Han JH, Kim DE, Lee CS

BACKGROUND: The dysfunction of the proteasome system has been implicated in neuronal degeneration. Apocynin, a specific inhibitor for nicotinamide adenine dinucleotide phosphate oxidase, has anti-inflammatory and anti-oxidant effects. However, the...
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Two Cases of Bortezomib-induced Drug Eruption Presenting as Multiple Plaques on the Trunk

Choe YS, Kim EJ, Na JI

  • KMID: 2245828
  • Korean J Dermatol.
  • 2016 Jan;54(1):47-51.
Bortezomib (Velcade(R)) is proteasome inhibitor that is used as a first-line therapy for multiple myeloma. It can cause gastrointestinal, hematologic, and neuromuscular side effects, and a cutaneous reaction is one...
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HIF-1alpha Upregulation due to Depletion of the Free Ubiquitin Pool

Kim J, So D, Shin HW, Chun YS, Park JW

Hypoxia-inducible factor 1alpha (HIF-1alpha), which transactivates a variety of hypoxia-induced genes, is rapidly degraded under nomoxia through the hydroxylation-ubiquitination-proteasome pathway. In this study, we addressed how HIF-1alpha is stabilized by...
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A Case of Acute Pancreatitis Caused by Bortezomib in a Patient with Multiple Myeloma

Lim JH, Hwang KB, Lim BH, Jeong YH, Sohn KC, Kim TH

Bortezomib is a proteasome inhibitor used for the treatment of patients with multiple myeloma. Recently, several case reports about acute pancreatitis caused by Bortezomib were published in the international literature....
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Novel Agents for Treatment of Multiple Myeloma

Kim HJ

Multiple myeloma (MM) is a neoplasm of clonal plasma cells that closely interacts with the bone marrow (BM) microenvironment. The overall survival of patients with MM has improved dramatically in...
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The Effect of Bortezomib on Expression of Inflammatory Cytokines and Survival in a Murine Sepsis Model Induced by Cecal Ligation and Puncture

Han SH, Kim JS, Woo JH, Jeong SJ, Shin JS, Ahn YS, Kim JM

PURPOSE: Although the proteasome inhibitor known as bortezomib can modulate the inflammatory process through the nuclear factor-kappa B signaling pathway, the immunomodulatory effect of pre-incubated bortezomib has not been fully...
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Bis is Induced by Oxidative Stress via Activation of HSF1

Yoo HJ, Im CN, Youn DY, Yun HH, Lee JH

The Bis protein is known to be involved in a variety of cellular processes including apoptosis, migration, autophagy as well as protein quality control. Bis expression is induced in response...
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Treatment of Refractory Antibody-mediated Rejection with Bortezomib in a Kidney Transplant Recipient: A Case Report

Lee JY, Yoo JY, Kwon SH, Jeon JS, Noh H, Han DC, Song D, Jin SY

Antibody-mediated rejection (ABMR) is associated with poor renal allograft survival. It shows poor response to conventional treatment with plasmapheresis, rituximab, and intravenous immunoglobulin. Bortezomib, a proteasome inhibitor used for treatment...
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Transcriptional Upregulation of Plasminogen Activator Inhibitor-1 in Rat Primary Astrocytes by a Proteasomal Inhibitor MG132

Cho KS, Kwon KJ, Jeon SJ, Joo SH, Kim KC, Cheong JH, Bahn GH, Kim HY, Han SH, Shin CY, Yang SI

  • KMID: 1502511
  • Biomol Ther.
  • 2013 Mar;21(2):107-113.
Plasminogen activator inhibitor-1 (PAI-1) is a member of serine protease inhibitor family, which regulates the activity of tissue plasminogen activator (tPA). In CNS, tPA/PAI-1 activity is involved in the regulation...
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Medaka Fish Parkinson's Disease Model

Matsui H, Gavinio R, Takahashi

The teleost fish has been widely used in creating neurodegenerative models. Here we describe the teleost medaka fish Parkinson's disease (PD) models we developed using toxin treatment and genetic engineering....
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Proteasome-Inhibitor-Based Primary Therapy for Antibody-Mediated Rejection in a Renal Transplant Recipient

Park SJ, Yu H, Kang SH, Baek SD, Baek CH, Jeong JH, Park SK

  • KMID: 2264162
  • Korean J Med.
  • 2011 Dec;81(6):780-785.
Donor-specific anti-human leukocyte antigen antibodies (DSA) following kidney transplantation predict the evolution of humoral rejection and reduced graft survival. Rapid, complete elimination of DSA during antibody-mediated rejection (AMR) is rarely...
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Up-regulation of the DR5 Expression by Proteasome Inhibitor MG132 Augments TRAIL-Induced Apoptosis in Soft Tissue Sarcoma Cell Lines

Cheong HJ, Lee KS, Woo IS, Won JH, Byun JH

  • KMID: 2167538
  • Cancer Res Treat.
  • 2011 Jun;43(2):124-130.
PURPOSE: Current chemotherapeutics for treating locally advanced or metastatic soft tissue sarcomas (STS) are limited. Accordingly, the present in vitro study was conducted to evaluate the effects of treatment of...
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Combination Therapy of Bortezomib (PS-341) and SAHA (Vorinostat) in Non-Small Cell Lung Cancer Cell Lines

Park MY, Kim DR, Park JS, Cho YJ, Lee SW, Yoon HI, Lee JH, Lee CT

PURPOSE: The recent introduction of targeted therapy for non-small cell lung cancer (NSCLC) has changed the paradigm of lung cancer chemotherapy. However, only a small portion of NSCLC patients received...
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Selective Susceptibility of Human Dopaminergic Neural Stem Cells to Dopamine-Induced Apoptosis

Jeon SM, Cheon SM, Bae HR, Kim JW, Kim SU

Dysfunctions of ubiquitin-proteasome system and toxicity of dopamine have been known as the key mechanisms in the pathogenesis of Parkinson's disease (PD) and proteasome inhibitors are widely used in experimental...
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A Case of Bortezomib-Associated Cutaneous Lymphocytic Vasculitis

Lee KJ, Kim JE, Park HJ, Lee JY, Cho BK

  • KMID: 2247734
  • Korean J Dermatol.
  • 2009 Dec;47(12):1392-1396.
Bortezomib (Velcade(R)) is a newly developed chemotherapeutic agent that is mainly used for the treatment of multiple myeloma. It is a selective and reversible inhibitor of proteasome, which is a...
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