J Korean Rheum Assoc.
2003 Jun;10(2):166-175.
Glutathione S-transferase M1, T1 and P1 Gene Polymorphisms and Carotid Atherosclerosis in Korean Patients with Rheumatoid Arthritis
- Affiliations
-
- 1Department of Internal Medicine, The Hospital for Rheumatic Diseases, Hanyang University Medical Center, Seoul, Republic of Korea.
- 2Department of Nutritional Sciences, University of Toronto, Toronto, Canada.
- 3Department of Radiology, Hanyang University College of Medicine, Seoul, Republic of Korea.
- 4Department of Internal Medicine, Gwangmyung Sungae General Hospital, Gwangmyeong, Gyeonggi-do, Republic of Korea.
Abstract
OBJECTIVE
We assessed the contribution of genetic polymorphisms of glutathione S-transferase M1 (GSTM1), T1 (GSTT1), and P1 (GSTP1, Ile105Val) to carotid atherosclerosis in 40 postmenopausal rheumatoid arthritis (RA) women without histories of smoking.
METHODS
We measured mean intima-media thickness (IMT) and plaque of the common carotid arteries by ultrasonography, and evaluated relations among the known risk factors for atherosclerosis, genetic polymorphisms, RA outcomes and markers of inflammation.
RESULTS
Subjects with the GSTT1-null genotype had greater IMT (p<0.05). On univariate analysis, carotid IMT was positively associated with age, systolic BP, antihypertensive drug use and the GSTT1-null genotype (p<0.05). When compared to subjects with a double- positive GSTM1/T1 genotype, IMT in subjects with concurrent lack of the GSTM1 and GSTT1 gene was significantly increased (p=0.008).
CONCLUSION
This study suggests that the GSTT1-null genotype might have an interaction with carotid atherosclerosis related to RA in Korean postmenopausal RA women free of smoking history.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Association between Antipsychotic-Induced Restless Legs Syndrome and Glutathione S-Transferase Gst-M1, Gst-T1 and Gst-P1 Gene Polymorphisms
- Lack of Association between Glutathione S-Transferase-M1, -T1, and -P1 Polymorphisms and Olanzapine-Induced Weight Gain in Korean Schizophrenic Patients
- Association of Polymorphism in Glutathione S-transferase Gene with Susceptibility and Severity of Rheumatoid Arthritis
- Estrogen receptor 1, Glutathione S-transferase P1, Glutathione S-transferase M1, and Glutathione S-transferase T1 Genes with Dysmenorrhea in Korean Female Adolescents
- GST (GSTM1, GSTT1, and GSTP1) polymorphisms in the genetic susceptibility of Turkish patients to cervical cancer
