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The effects of coenzyme Q₁₀ supplement on blood lipid indices and hepatic antioxidant defense system in SD rats fed a high cholesterol diet

Kim HN, Jeon DG, Lim Y, Jang IS

A total of 24 SD rats were allotted to four treatment groups such as the control (CON), 1% of cholesterol diet (CHO), 0.5% of coenzyme Q₁₀ (COQ) and 1% of...
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Supplementation with psyllium seed husk reduces myocardial damage in a rat model of ischemia/reperfusion

Lim SH, Lee J

BACKGROUND/OBJECTIVES: Myocardial infarction (MI) is caused by extensive myocardial damage attributed to the occlusion of coronary arteries. Our previous study in a rat model of ischemia/reperfusion (I/R) demonstrated that administration...
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Comparison of Squamous Cell Carcinoma of the Tongue between Young and Old Patients

Choi G, Song JS, Choi SH, Nam SY, Kim SY, Roh JL, Lee BK, Cho KJ

BACKGROUND: The worldwide incidence of squamous cell carcinoma of the tongue (SCCOT) in young patients has been increasing. We investigated clinicopathologic features of this unique population and compared them with...
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Effects of dietary lipid-coated zinc on the antioxidant defense system in the small intestine and liver of piglets

Kim HN, Jeon DG, Lee CY, Jang IS

The purpose of the study was to investigate the effects of lipid-coated ZnO (LCZ) and the level of LCZ compared with ordinary zinc oxide (ZnO) on antioxidant defense system in...
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Modulated Gene Expression of Toxoplasma gondii Infected Retinal Pigment Epithelial Cell Line (ARPE-19) via PI3K/Akt or mTOR Signal Pathway

Zhou W, Quan JH, Gao FF, Ismail HA, Lee YH, Cha GH

Due to the critical location and physiological activities of the retinal pigment epithelial (RPE) cell, it is constantly subjected to contact with various infectious agents and inflammatory mediators. However, little...
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Effects of glutathione s-transferase (GST) M1 and T1 polymorphisms on antioxidant vitamins and oxidative stress-related parameters in Korean subclinical hypertensive subjects after kale juice (Brassica oleracea acephala) supplementation

Lee HJ, Han JH, Park YK, Kang MH

BACKGROUND/OBJECTIVES: Glutathione s-transferase (GST) is involved in the formation of a multigene family comprising phase II detoxification enzymes, involved in the detoxification of reactive oxygen species. This study evaluated whether...
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Lymphocyte DNA damage and plasma antioxidant status in Korean subclinical hypertensive patients by glutathione S-transferase polymorphism

Han JH, Lee HJ, Choi HJ, Yun KE, Kang MH

BACKGROUND/OBJECTIVES: Glutathione S-transferase (GST) forms a multigene family of phase II detoxification enzymes which are involved in the detoxification of xenobiotics by conjugating substances with glutathione. The aim of this...
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Antioxidant mechanism of black garlic extract involving nuclear factor erythroid 2-like factor 2 pathway

Ha AW, Kim WK

BACKGROUN/OBJECTIVES: Although studies have revealed that black garlic is a potent antioxidant, its antioxidant mechanism remains unclear. The objective of this study was to determine black garlic's antioxidant activities and...
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Effects of lymphocyte DNA damage levels in Korean plant food groups and Korean diet regarding to glutathione S-transferase M1 and T1 polymorphisms

Kim HA, Lee MY, Kang MH

PURPOSE: GST (glutathione S-transferase) M1 and T1 gene polymorphisms are known to affect antioxidant levels. This study was carried out to evaluate genetic susceptibility by measuring the effect of DNA...
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Isoegomaketone Upregulates Heme Oxygenase-1 in RAW264.7 Cells via ROS/p38 MAPK/Nrf2 Pathway

Jin CH, So YK, Han SN, Kim JB

Isoegomaketone (IK) was isolated from Perilla frutescens, which has been widely used as a food in Asian cuisine, and evaluated for its biological activity. We have already confirmed that IK...
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Oxidative Stress in the Heart of Rats Infected with Trypanosoma evansi

Baldissera MD, Souza CD, Bertoncheli CM, da Silveira KL, Grando TH, Porto BC, Leal DB, Silva AS, Mendes RE, Stefani LM, Monteiro S

This study was conducted to investigate the occurrence of oxidative stress in the heart tissue of rats infected with Trypanosoma evansi. Rats were divided into 2 groups (A and B)...
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Effects of lutein or lutein in combination with vitamin C on mRNA expression and activity of antioxidant enzymes and status of the antioxidant system in SD rats

Song MH, Shin EC, Hwang DY, Jang IS

This study was conducted to investigate the effects of lutein alone or in combination with vitamin C on the antioxidant defense system in rats. A total of 18 eight-week-old male...
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Association between Antipsychotic-Induced Restless Legs Syndrome and Glutathione S-Transferase Gst-M1, Gst-T1 and Gst-P1 Gene Polymorphisms

Kang SG, Park YM, Kim L, Lee HJ

OBJECTIVES: The pathophysiology of restless legs syndrome (RLS) has not been fully elucidated. Oxidative stress might play a role in the development of RLS and other antipsychotic-induced side effects such...
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Human coagulation factor VIII domain-specific recombinant polypeptide expression

Choi SJ, Jang KJ, Lim JA, Kim HS

BACKGROUND: Hemophilia A is caused by heterogeneous mutations in F8. Coagulation factor VIII (FVIII), the product of F8, is composed of multiple domains designated A1-A2-B-A3-C1-C2. FVIII is known to interact...
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The effect of glutathione S-transferase M1 and T1 polymorphisms on blood pressure, blood glucose, and lipid profiles following the supplementation of kale (Brassica oleracea acephala) juice in South Korean subclinical hypertensive patients

Han JH, Lee HJ, Kim TS, Kang MH

BACKGROUND/OBJECTIVES: Glutathione S-transferase (GST) forms a multigene family of phase II detoxification enzymes which are involved in the detoxification of reactive oxygen species. This study examines whether daily supplementation of...
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Oxidative damage biomarker levels according to Mn-SOD and GST gene polymorphisms in preschool children

Shin YK, Choi JW, Oh SY, Chung J

PURPOSE: Genetic polymorphisms in antioxidant defense and detoxification genes may modulate the levels of oxidative stress biomarkers. METHODS: A total of 301 healthy preschool-aged children in the Seoul and Kyung-gi areas...
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Coffee Enema for Preparation for Small Bowel Video Capsule Endoscopy: A Pilot Study

Kim ES, Chun HJ, Keum B, Seo YS, Jeen YT, Lee HS, Um SH, Kim CD, Ryu HS

Coffee enemas are believed to cause dilatation of bile ducts and excretion of bile through the colon wall. Proponents of coffee enemas claim that the cafestol palmitate in coffee enhances...
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Schisandra Chinensis Baillon regulates the gene expression of phase II antioxidant/detoxifying enzymes in hepatic damage induced rats

Jang HI, Do GM, Lee HM, Ok HM, Shin JH, Kwon O

  • KMID: 2313739
  • Nutr Res Pract.
  • 2014 Jun;8(3):272-277.
BACKGROUND/OBJECTIVES: This study investigated the antioxidant activities and hepatoprotective effects of Schisandra chinensis Baillon extract (SCE) against tert-butyl hydroperoxide (t-BHP)-induced oxidative hepatic damage in rats. MATERIALS/METHODS: Sprague-Dawley (SD) rats were pretreated...
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Protective effects of pine bark extract against cisplatin-induced hepatotoxicity and oxidative stress in rats

Ko JW, Lee IC, Park SH, Moon C, Kang SS, Kim SH, Kim JC

We investigated the protective effects of pine bark extract (pycnogenol(R), PYC) against cisplatin-induced hepatotoxicity and oxidative stress in rats. Twenty-four male rats were divided into the following four groups: (1)...
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Association between Glutathione S-Transferase T1, M1, and P1 Genotypes and the Risk of Colorectal Cancer

Cong N, Liu L, Xie Y, Shao W, Song J

Glutathione S-transferases (GSTs) are enzymes which play an important role in the neutralization of toxic compounds and eradication of electrophilic carcinogens. Genetic polymorphisms within the genes encoding for GSTs may...
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