Sleep Med Psychophysiol.
2015 Jun;22(1):25-29. 10.14401/KASMED.2015.22.1.25.
Association between Antipsychotic-Induced Restless Legs Syndrome and Glutathione S-Transferase Gst-M1, Gst-T1 and Gst-P1 Gene Polymorphisms
- Affiliations
-
- 1Department of Psychiatry, Gil Medical Center, Gachon University, School of Medicine, Incheon, Korea.
- 2Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
- 3Department of Psychiatry, Korea University College of Medicine, Seoul, Korea. leehjeong@korea.ac.kr
- KMID: 2317598
- DOI: http://doi.org/10.14401/KASMED.2015.22.1.25
Abstract
OBJECTIVES
The pathophysiology of restless legs syndrome (RLS) has not been fully elucidated. Oxidative stress might play a role in the development of RLS and other antipsychotic-induced side effects such as tardive dyskinesia. In the present study, we investigated whether the glutathione S-transferase (GST) gene polymorphisms are associated with antipsychotic-induced RLS in schizophrenia.
METHODS
We assessed antipsychotic-induced RLS symptoms in 190 Korean schizophrenic patients using the diagnostic criteria of the International Restless Legs Syndrome Study Group. The GST-M1, GST-T1 and GST-P1 loci were analyzed using PCR-based methods.
RESULTS
We divided the subjects into 2 groups: those with RLS symptoms (n = 96) and those without RLS symptoms (n = 94). There were no significant differences in the distributions of the GST-M1 genotypes (chi2 = 3.56, p = 0.059), GST-T1 (chi2 = 0.51, p = 0.476) and GST-P1 (chi2 = 0.57, p = 0.821) between the 2 groups. Comparison of the RLS score among genotypes of the GST-M1 (t = -1.54, p = 0.125), GST-T1 (t = -0.02, p = 0.985) and GST-P1 (F = 0.58, p = 0.560) revealed no significant difference.
CONCLUSION
These data suggest that GST gene polymorphisms do not confer increased susceptibility to RLS symptoms in schizophrenic patients. Future studies are necessary to evaluate the possible influences of other candidate genes involved in the reactive oxygen species system.
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