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Soluble CD40 Levels in Plasma Are Associated with Cardiovascular Disease and in Carotid Plaques with a Vulnerable Phenotype

Shami A, Edsfeldt A, Bengtsson E, Nilsson J, Shore AC, Natali A, Khan F, Lutgens E, Gonçalves I

Background and Purpose CD40 and CD40 ligand (CD40L) are costimulatory molecules of the tumor necrosis factor receptor superfamily and well known for their involvement in inflammatory diseases: atherosclerotic mouse models...
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Is Biochemical Follow Up Possible in Peripheral Arterial Disease Treatment: Hypoxia Inducible Factor-1 Alpha?

Yücel C, Gürsoy M, Ketenciler S, Tenekeciğil A, Kızıltan F, Kayalar N

Purpose: The hypoxia inducible factor (HIF)-1 is a dimeric protein complex that plays an integral role in the body’s response to hypoxia. This study aimed to analyze the regulation of...
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Psoriasis and Cardiovascular Disease: A Narrative Review

Martinez-Moreno A, Ocampo-Candiani J, Garza-Rodriguez V

Psoriasis is a chronic, autoimmune, and inflammatory disease that affects 2% of the world’s population. In recent years, it has been demonstrated that psoriasis confers a 25% increase in relative...
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Risk Factors of Coronary Calcium Onset in Healthy Japanese Individuals: A Longitudinal Study Using Low-Dose Chest CT

Izoe Y, Nagao M, Chida K

Objective: Detection of coronary artery calcification (CAC) in healthy individuals and investigation of this risk factor are useful for preventing heart disease. One aim of this study was to quantify...
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Evolution of Cardiac CT Imaging and Education in Singapore

Hoe J

This paper describes the evolution of cardiac CT imaging as a clinical service and the role of education of users of cardiac CT in Singapore from its start in 2003...
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Bioactive Sphingolipids as Major Regulators of Coronary Artery Disease

Song JH, Kim GT, Park KH, Park WJ, Park TS

  • KMID: 2517155
  • Biomol Ther.
  • 2021 Jul;29(4):373-383.
Atherosclerosis is the deposition of plaque in the main arteries. It is an inflammatory condition involving the accumulation of macrophages and various lipids (low-density lipoprotein [LDL] cholesterol, ceramide, S1P). Moreover,...
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Factors Contributing to an Efficacious Endovascular Treatment for Acute Ischemic Stroke in Asian Population

Lee JS, Hwang YH, Sohn SI

Although randomized control trials about endovascular treatment (EVT) of emergent large vessel occlusion (LVO) have demonstrated the success of mechanical thrombectomy as the choice of treatment, a wide range of...
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Effect of Rosuvastatin on Coronary Flow Reserve in Hypertensive Patients at Cardiovascular Risk

Yang Y, Hwang E, Lee SA, Lee S, Kim DH, Song JM, Kang DH

BACKGROUND: It has been unclear whether statin therapy directly improves coronary flow reserve (CFR) in hypertensive patients at cardiovascular risk, independent of lifestyle modification and antihypertensive medications. METHODS: In this double-blind,...
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Noninvasive prediction of carotid artery atherosclerosis by multiple abdominal fat indices measured via ultrasonography

Hazem M, Elsamman M, Bazeed S, Zaki M

Purpose: The purpose of this study was to evaluate the efficiency of multiple abdominal fat indices as measured via ultrasonography for predicting the presence and severity of carotid artery atherosclerosis...
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The Optical Coherence Tomographic Findings Which Predict Outcome of Calcified Coronary Lesions after Percutaneous Coronary Intervention: A Serial Follow-up Study

Jang J, Kang SH, Cho YS, Shin ES, Suh JW

Objective: Imaging modalities such as intravascular ultrasonography or computed tomography or angiography have shown limitations in assessing coronary calcification. In this study, we investigated whether quantitative indices of optical coherence...
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Proximal basilar artery hemorrhage after submaximal angioplasty for intracranial atherosclerotic disease presenting as a large vessel occlusion treated with pipeline embolization device

Johnson RM, Young M, Guglielmi GN, Farhat H

Iatrogenic vessel perforation from endovascular intervention is a devastating complication that commonly is treated with vessel sacrifice. We present a unique case of an iatrogenic proximal basilar artery perforation after...
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Extract of Curcuma zedoaria R. prevents atherosclerosis in apolipoprotein E-deficient mice

Kim KM, Lee JY, Jeon BH, Quan KT, Na M, Nam KW, Chae S

BACKGROUND/OBJECTIVES: Curcuma zedoaria R. (Zingiberaceae) has been used to treat headache, fever, and hypertension-related symptoms in Asian countries, including Korea, China, and Japan. We investigated whether dietary intake of a...
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Targeting the culprit: vessel wall magnetic resonance imaging for evaluating stroke

Kim SM, Ha SH, Kwon H, Kim YJ, Ahn SH, Kim BJ

The pathogenesis of many strokes originates in the vessel wall. Despite this, most traditional imaging focuses on the vascular lumen. Vessel-wall magnetic resonance imaging (VWMRI) is useful for establishing the...
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Preliminary Experience of Neuroform Atlas Stenting as a Rescue Treatment after Failure of Mechanical Thrombectomy Caused by Residual Intracranial Atherosclerotic Stenosis

Yi HJ, Sung JH, Lee DH

Objective : The low-profile Neuroform Atlas stent can be deployed directly without an exchange maneuver by navigating into the Gateway balloon. This retrospective study assessed the safety and efficacy of...
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Effects of Glucagon-Like Peptide-1 Analogue and Fibroblast Growth Factor 21 Combination on the Atherosclerosis-Related Process in a Type 2 Diabetes Mouse Model

Kim JH, Lee GY, Maeng HJ, Kim H, Bae JH, Kim KM, Lim S

Background: Glucagon-like peptide-1 (GLP-1) analogues regulate glucose homeostasis and have anti-inflammatory properties, but cause gastrointestinal side effects. The fibroblast growth factor 21 (FGF21) is a hormonal regulator of lipid and...
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Role of Genetics in Preventive Cardiology: Focused on Dyslipidemia

Lee SH

Dyslipidemia is a strong risk factor for cardiovascular disease as well as a major target for its prevention. Along with the progress in genetic research techniques and bioinformatics analysis, genetic...
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Recent Updates of Lipoprotein(a) and Cardiovascular Disease

Liu T, Yoon WS, Lee SR

In recent years, epidemiological studies, genome-wide association studies, and Mendelian randomization studies have shown a strong association between increased levels of lipoproteins and increased risks of coronary heart disease and...
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Decreased 18F-Fluorodeoxyglucose Uptake in Lumbar Vertebrae of Stroke Patients

Kim JM, Lee ES, Park KY, Seok JW

Background and Purpose We investigated 18F-fluorodeoxyglucose (FDG) uptake levels in the lumbar vertebrae, liver, and spleen of stroke patients with carotid atherosclerosis. Methods This study analyzed acute ischemic stroke patients with...
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Zebrafish as an Emerging Model for Dyslipidemia and Associated Diseases

Ka J, Jin SW

Dyslipidemia related diseases such as hyperlipidemia and atherosclerosis are the leading cause of death in humans. While cellular and molecular basis on the pathophysiology of dyslipidemia has been extensively investigated...
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Nlrp3, Csf3, and Edn1 in Macrophage Response to Saturated Fatty Acids and Modified Low-Density Lipoprotein

Youk H, Kim M, Lee CJ, Oh J, Park S, Kang SM, Kim JH, Ann Sj, Lee SH

Background and Objectives: The relationship between metabolic stress, inflammation, and cardiovascular disease is being studied steadily. The aim of this study was to evaluate the effect of palmitate (PA) and...
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