Korean J Nephrol.
2002 Nov;21(6):1037-1042.
A Case of Tuberculosis-associated Hemophagocytic Syndrome in Renal Transplant Recipient
- Affiliations
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- 1Departments of Internal Medicine, College of Medicine,The Catholic University of Korea, Seoul, Korea. drsykim@catholic.ac.kr
- 2Departments of Pathology College of Medicine, The Catholic University of Korea, Seoul, Korea.
Abstract
- Hemophagocytic syndrome is a rare syndrome characterized by fever, weight loss, profound pancytopenia, lymphadenopathy, hepatosplenomegaly and the pathologic finding of hemophagocytosis (phagocytosis by macrophages of erythrocytes, leukocytes, platelets, and their precursors) in bone marrow and other tissue. This syndrome can be associated with viral infections and lymphoid neoplasia, bacteria, fungus and drugs. Hyperproduction of cytokines, including interferon-gamma, tumor necrosis factor-alpha, may play a role in the pathogenesis of hemophagocytosis. Authors experienced a rare case of hemophagocytic syndrome associated with tuberculosis in a 40-year- old female who had undergone renal transplantation 12 years ago and received triple immunotherapy. After the beginning of antituberculosis therapy, the laboratory disturbances disappeared and clinical symptoms improved. Tuberculosis is a common infection in Korea. Therefore, we would like to recommend early bone marrow biopsy and antituberculosis therapy if fever of unknown origin, hepatosplenomegaly and pancytopenia in immunosupressive patients.
MeSH Terms
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Bacteria
Biopsy
Bone Marrow
Cytokines
Erythrocytes
Female
Fever
Fever of Unknown Origin
Fungi
Humans
Immunotherapy
Interferon-gamma
Kidney Transplantation
Korea
Leukocytes
Lymphatic Diseases
Lymphohistiocytosis, Hemophagocytic*
Macrophages
Pancytopenia
Transplantation*
Tuberculosis
Tumor Necrosis Factor-alpha
Weight Loss
Cytokines
Interferon-gamma
Tumor Necrosis Factor-alpha
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