Korean J Pathol.  2006 Feb;40(1):52-59.

Expression of Anaphase Promoting Complex in Surgically Resected Squamous Cell Carcinoma and Adenocarcinoma of the Lung

• Song JS
• Jung SH
• Eom M
• Yi SY
• Park KH
• Kang Y
• Kim HY

Abstract

BACKGROUND: The anaphase promoting complex (APC) promotes the degradation of mitotic cyclins as well as other substrates involved in sister chromatid adhesion. This study was carried out to examine the relationship between the APC expression and the clinicopathological variables, in an attempt to determine the role of the APC in the proliferation of lung cancer and to evaluate the possibility of an aberrant APC function in surgically resected squamous cell carcinomas and adenocarcinomas of the lung.
METHODS
Immunohistochemical staining was performed for APC, Ki-67, cyclin B1, Cdc2, MMP-2 and VEGF in 55 cases of squamous cell carcinoma and 34 cases of adenocarcinoma of the lung, using the avidin-biotin-peroxidase method.
RESULTS
The immunohistochemical stains for APC revealed a positive reaction in 49 cases (55.1%). The APC expression level was higher in the cyclin B1-positive group (p= 0.01), the Cdc2-positive group (p=0.001), the MMP-2-positive group (p=0.03), the group with lymph node metastasis (61.4% vs 48.9%), and the group with stage II/III cancer (60.7%) compared with those with stage I (42.9%).
CONCLUSIONS
The APC may have an aberrant function, such as a change in its role in controlling the cell cycle, and might be associated with the invasiveness and proliferation of tumor cells.

Keyword

Anaphase-promoting complex; Squamous cell carcinoma; Adenocarcinoma; Lung cancer; Cell cycle

MeSH Terms

Adenocarcinoma*
Anaphase*
Anaphase-Promoting Complex-Cyclosome*
Carcinoma, Squamous Cell*
Cell Cycle
Chromatids
Coloring Agents
Cyclin B1
Cyclins
Humans
Lung Neoplasms
Lung*
Lymph Nodes
Neoplasm Metastasis
Siblings
Vascular Endothelial Growth Factor A
Coloring Agents
Cyclin B1
Cyclins
Vascular Endothelial Growth Factor A