- Chromosomal Instability in the Peripheral Blood Lymphocytes of an Ovarian Cancer Patient Undergoing Chemotherapy
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Oh SJ, Moon HS, Huh J
- KMID: 2312210
- Lab Med Online.
- 2012 Oct;2(4):223-225.
Chemotherapy agents can induce chromosomal instability, including a variety of chromatid or chromosomal aberrations. However, only limited data is available on the effect of chemotherapy on the kinetics of chromosomal... -
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- Monocentric Derivative Y Chromosome with Duplication of the SRY Gene in an Azoospermic Male
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Choi EY, Lee BY, Park JY, Lee YW, Oh AR, Lee SY, Kim SY, Han YJ, Lee MB, Ryu HM, Seo JT, Park SY
- KMID: 2184483
- J Genet Med.
- 2010 Dec;7(2):160-164.
Structural abnormalities of the Y chromosome affect normal testicular differentiation and spermatogenesis. The present case showed a rare monocentric derivative Y chromosome with partial duplication of Yp including the SRY... -
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- Pathways and genes of DNA double-strand break repair associated with head and neck cancer
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Oh JH, Lee DW, Ryu DM
- KMID: 2118310
- J Korean Assoc Oral Maxillofac Surg.
- 2009 Feb;35(1):1-6.
DNA double-strand breaks (DSBs) occur commonly in the all living and in cycling cells. They constitute one of the most severe form of DNA damage, because they affect both strand... -
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- Identification of hRad21-Binding Sites in Human Chromosome
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Chin C, Chung BS
- KMID: 2166189
- Genomics Inform.
- 2006 Mar;4(1):11-15.
The aim of this study is to identify hRad21-binding sites in human chromosome, the core component of cohesin complex that held sister chromatids together. After chromatin immunoprecipitation with an hRad21... -
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- Expression of Anaphase Promoting Complex in Surgically Resected Squamous Cell Carcinoma and Adenocarcinoma of the Lung
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Song JS, Jung SH, Eom M, Yi SY, Park KH, Kang Y, Kim HY
- KMID: 1593163
- Korean J Pathol.
- 2006 Feb;40(1):52-59.
BACKGROUND: The anaphase promoting complex (APC) promotes the degradation of mitotic cyclins as well as other substrates involved in sister chromatid adhesion. This study was carried out to examine the... -
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- Relationship between Expression of Anaphase-promoting Complex and Prognostic Factors in Invasive Ductal Carcinoma of Breast
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Eom M, Park KH, Lee KG, Yi SY, Kang Y, Jung SH
- KMID: 1725952
- Korean J Pathol.
- 2003 Feb;37(1):19-25.
BACKGROUND: The role of the anaphase-promoting complex (APC) is to promote the degradation of mitotic cyclins and other substrates involved in sister chromatid adhesions. The APC appears to be responsible... -
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- Chromosome Aberrations and Sister Chromatid Exchanges of Hospital Workers Exposed to Radiation
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Cha AR, Kim MS, Hwang IK, Lee SI, Cho BM, Kim DK
- KMID: 2282955
- Korean J Prev Med.
- 1998 Nov;31(4):616-627.
In order to evaluate the cytogenetic hazard among hospital workers potentially exposed to low dose of radiation, the analysis of chromosome aberrations(CA) and sister chromatid exchanges(SCE) in lymphocytes were performed... -
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- Ultrastructural Injury and Its Mechanism of Cultured Cardiac Myocytes under Anoxia-Reoxygenation
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Park JH, Kim JY, Jeong SR, Lee YC
- KMID: 1530059
- Korean J Anat.
- 1998 Apr;31(2):225-240.
Abrupt reoxygenation (or reperfusion) after anoxia (or ischemia)-induced injury resulted in the loss of contractile property, destruction of cell organelles, and ultimately, cell death in cardiac myocytes. This phenomenon has... -
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- The Study of Chromosomal Aberration in NSCLC Patients which Developed after Administration of Chemotherapeutic Agents
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Cha WK, Lee JY, Shinn JJ, Lee HK, Yu KH, Song JS, Yang KH, Kim ES, Kim JS
- KMID: 1906182
- J Korean Cancer Assoc.
- 1997 Jun;29(3):504-511.
PURPOSE: Except hormonal agents and biologic response modifier, the biologic effects of chemotherapy and radiotherapy as anti-cancer therapy have the mechanism of DNA injury. They cause not only cancer cell... -
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- The effects of chromium exposure on sister chromatid exchange and concentration of 8-hydroxydeoxyguanosine
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Han SH, Cho SH, Kim H, Park SM, Ha M, Joo YS, Kwon HJ, Kwon YD, Kwon MH
- KMID: 2282757
- Korean J Prev Med.
- 1995 Jun;28(2):511-525.
To elucidate some DNA adducts as a biological marker for workers of chromate pigment, the effects of chromium exposure on the formation of 8-hydroxydeoxyguanosine(8-OH-dG) and sister chromatid exchanges(SCEs) frequency in... -
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- Development of Methods to Estimate Exposure Levels to Vinyl Chloride Monomer and Multiphasic Screening Tests for Workers of Polyvinyl Chloride Manufacturing Factories
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Kim H, Nam YJ, Kim ST, Kim DY, Han SH, Park KT
- KMID: 2074939
- Korean J Occup Environ Med.
- 1994 Sep;6(2):201-218.
In order to develop questionnaire estimating vinyl chloride monomer(VCM) exposure levels, to reset selection criteria for detailed tests, to measure current VCM exposure levels, to evaluate the mutagenic effects of... -
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- Adaptive Response to lonizing Radiation Induced by Low Doses of Gamma Rays in Human Lymphoblastoid Cell Lines
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Seong J, Kim GE, Suh CO
- KMID: 2196826
- J Korean Soc Ther Radiol.
- 1994 Feb;12(1):1-8.
When cells are exposed to low doses of a mutagenic or clastogenic agents, they often become less sensitive to the effects of a higher does administered subsequently. Such adaptive responses... -
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- Radiation Induced G2 Chromatic Break and Repairs Kinetics in Human Lymphoblastoid Cells
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Seong J
- KMID: 2097427
- J Korean Soc Ther Radiol.
- 1993 Dec;11(2):193-204.
In understanding radiosensitivity a new concept of inherent radiosensitivity based on individuality and heterogeneity within a population has recently beer explored. There has been some discussion of possible mechanism underlying... -
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- Sister chromatid exchange(SCE) and chromosome abberrations inFanconi's anemia.
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Jung YW, Chang SI, Hu CG
- KMID: 1698786
- Korean J Phys Anthropol.
- 1991 Dec;4(2):137-144.
No abstract available. -
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- Sister Chromatid Exchanges in Lymphocytes of Some Workers Exposed to Hexavalent Chromium
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Shin DH, Yoon NK, Suh SK, Yeh MH
- KMID: 2282486
- Korean J Prev Med.
- 1990 Sep;23(3):358-368.
To investigate the possibility of utilizing of sister chromatid exchange(SCE) analysis in lymphocytes as an indicator which could evaluate the effects of mutagenicity after in vivo exposure to hexavalent chromium,... -
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- Selenium Effect on the Frequency of SCEs Induced by Heavy Metals in Human Lymphocytes
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Koh DH, Ki NS
- KMID: 2282457
- Korean J Prev Med.
- 1990 Mar;23(1):1-10.
The protective effect of sodium selenite (Na2SeO3) against the cytogenetic toxicity of heavy metals was investigated on human whole-blood cultures in relation to induction of sister chromatid exchange(SCE) in secondary... -
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- Effect of Several Heavy Metals on the Frequencies of Sister Chromatid Exchanges and Chromosomal Aberrations in Human Lymphocytes
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Jung CD, Lee JS, Koh DH, Ki NS, Hwang ID
- KMID: 2282427
- Korean J Prev Med.
- 1989 Mar;22(1):116-124.
To assay the cytogenetic toxicity of NiCl, K2Cr2O7CdC12, and HgC12, the frequencies of sister chromatid exchanges(SCEs) and chromosomal aberrations were observed in the metaphase chromosomes of the human lymphocytes which... -
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- Effects of Mitomycin C on Sister Chromatid Exchanges in Cultured Human Lympocytes
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Hwang ID, Ki NS, Lee JS, Kim NS, Mun TL
- KMID: 2282244
- Korean J Prev Med.
- 1986 Nov;19(2):244-251.
Sister chromatid exchanges(SCEs) and cell cycle kinetics were proposed as a sensitive and quantitative assay for mutagenicity and cytotoxicity in short-term cultures of phytohemagglutinin(PHA)-stimulated human lymphocytes. Therefore, this study was... -
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- Sister Chromatid Exchanges in Lymphocytes on Normal Human Blood culture with Mercury chloride or Methylmercury Chloride
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Koh DH
- KMID: 2282201
- Korean J Prev Med.
- 1984 Sep;17(1):245-250.
Reciprocal exchanges of DNA in sister chromatids (SCEs) are induced by various carcinogens and mutagens, although the quantitative relationship between the number of mutations and SCEs induced varies among chemicals.... -
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