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Chromosomal Instability in the Peripheral Blood Lymphocytes of an Ovarian Cancer Patient Undergoing Chemotherapy

Oh SJ, Moon HS, Huh J

  • KMID: 2312210
  • Lab Med Online.
  • 2012 Oct;2(4):223-225.
Chemotherapy agents can induce chromosomal instability, including a variety of chromatid or chromosomal aberrations. However, only limited data is available on the effect of chemotherapy on the kinetics of chromosomal...
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Monocentric Derivative Y Chromosome with Duplication of the SRY Gene in an Azoospermic Male

Choi EY, Lee BY, Park JY, Lee YW, Oh AR, Lee SY, Kim SY, Han YJ, Lee MB, Ryu HM, Seo JT, Park SY

  • KMID: 2184483
  • J Genet Med.
  • 2010 Dec;7(2):160-164.
Structural abnormalities of the Y chromosome affect normal testicular differentiation and spermatogenesis. The present case showed a rare monocentric derivative Y chromosome with partial duplication of Yp including the SRY...
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Pathways and genes of DNA double-strand break repair associated with head and neck cancer

Oh JH, Lee DW, Ryu DM

  • KMID: 2118310
  • J Korean Assoc Oral Maxillofac Surg.
  • 2009 Feb;35(1):1-6.
DNA double-strand breaks (DSBs) occur commonly in the all living and in cycling cells. They constitute one of the most severe form of DNA damage, because they affect both strand...
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Identification of hRad21-Binding Sites in Human Chromosome

Chin C, Chung BS

  • KMID: 2166189
  • Genomics Inform.
  • 2006 Mar;4(1):11-15.
The aim of this study is to identify hRad21-binding sites in human chromosome, the core component of cohesin complex that held sister chromatids together. After chromatin immunoprecipitation with an hRad21...
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Expression of Anaphase Promoting Complex in Surgically Resected Squamous Cell Carcinoma and Adenocarcinoma of the Lung

Song JS, Jung SH, Eom M, Yi SY, Park KH, Kang Y, Kim HY

  • KMID: 1593163
  • Korean J Pathol.
  • 2006 Feb;40(1):52-59.
BACKGROUND: The anaphase promoting complex (APC) promotes the degradation of mitotic cyclins as well as other substrates involved in sister chromatid adhesion. This study was carried out to examine the...
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Relationship between Expression of Anaphase-promoting Complex and Prognostic Factors in Invasive Ductal Carcinoma of Breast

Eom M, Park KH, Lee KG, Yi SY, Kang Y, Jung SH

  • KMID: 1725952
  • Korean J Pathol.
  • 2003 Feb;37(1):19-25.
BACKGROUND: The role of the anaphase-promoting complex (APC) is to promote the degradation of mitotic cyclins and other substrates involved in sister chromatid adhesions. The APC appears to be responsible...
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Chromosome Aberrations and Sister Chromatid Exchanges of Hospital Workers Exposed to Radiation

Cha AR, Kim MS, Hwang IK, Lee SI, Cho BM, Kim DK

  • KMID: 2282955
  • Korean J Prev Med.
  • 1998 Nov;31(4):616-627.
In order to evaluate the cytogenetic hazard among hospital workers potentially exposed to low dose of radiation, the analysis of chromosome aberrations(CA) and sister chromatid exchanges(SCE) in lymphocytes were performed...
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Ultrastructural Injury and Its Mechanism of Cultured Cardiac Myocytes under Anoxia-Reoxygenation

Park JH, Kim JY, Jeong SR, Lee YC

  • KMID: 1530059
  • Korean J Anat.
  • 1998 Apr;31(2):225-240.
Abrupt reoxygenation (or reperfusion) after anoxia (or ischemia)-induced injury resulted in the loss of contractile property, destruction of cell organelles, and ultimately, cell death in cardiac myocytes. This phenomenon has...
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The Study of Chromosomal Aberration in NSCLC Patients which Developed after Administration of Chemotherapeutic Agents

Cha WK, Lee JY, Shinn JJ, Lee HK, Yu KH, Song JS, Yang KH, Kim ES, Kim JS

  • KMID: 1906182
  • J Korean Cancer Assoc.
  • 1997 Jun;29(3):504-511.
PURPOSE: Except hormonal agents and biologic response modifier, the biologic effects of chemotherapy and radiotherapy as anti-cancer therapy have the mechanism of DNA injury. They cause not only cancer cell...
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The effects of chromium exposure on sister chromatid exchange and concentration of 8-hydroxydeoxyguanosine

Han SH, Cho SH, Kim H, Park SM, Ha M, Joo YS, Kwon HJ, Kwon YD, Kwon MH

  • KMID: 2282757
  • Korean J Prev Med.
  • 1995 Jun;28(2):511-525.
To elucidate some DNA adducts as a biological marker for workers of chromate pigment, the effects of chromium exposure on the formation of 8-hydroxydeoxyguanosine(8-OH-dG) and sister chromatid exchanges(SCEs) frequency in...
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Development of Methods to Estimate Exposure Levels to Vinyl Chloride Monomer and Multiphasic Screening Tests for Workers of Polyvinyl Chloride Manufacturing Factories

Kim H, Nam YJ, Kim ST, Kim DY, Han SH, Park KT

  • KMID: 2074939
  • Korean J Occup Environ Med.
  • 1994 Sep;6(2):201-218.
In order to develop questionnaire estimating vinyl chloride monomer(VCM) exposure levels, to reset selection criteria for detailed tests, to measure current VCM exposure levels, to evaluate the mutagenic effects of...
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Adaptive Response to lonizing Radiation Induced by Low Doses of Gamma Rays in Human Lymphoblastoid Cell Lines

Seong J, Kim GE, Suh CO

  • KMID: 2196826
  • J Korean Soc Ther Radiol.
  • 1994 Feb;12(1):1-8.
When cells are exposed to low doses of a mutagenic or clastogenic agents, they often become less sensitive to the effects of a higher does administered subsequently. Such adaptive responses...
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Radiation Induced G2 Chromatic Break and Repairs Kinetics in Human Lymphoblastoid Cells

Seong J

  • KMID: 2097427
  • J Korean Soc Ther Radiol.
  • 1993 Dec;11(2):193-204.
In understanding radiosensitivity a new concept of inherent radiosensitivity based on individuality and heterogeneity within a population has recently beer explored. There has been some discussion of possible mechanism underlying...
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Sister chromatid exchange(SCE) and chromosome abberrations inFanconi's anemia.

Jung YW, Chang SI, Hu CG

  • KMID: 1698786
  • Korean J Phys Anthropol.
  • 1991 Dec;4(2):137-144.
No abstract available.
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Sister Chromatid Exchanges in Lymphocytes of Some Workers Exposed to Hexavalent Chromium

Shin DH, Yoon NK, Suh SK, Yeh MH

  • KMID: 2282486
  • Korean J Prev Med.
  • 1990 Sep;23(3):358-368.
To investigate the possibility of utilizing of sister chromatid exchange(SCE) analysis in lymphocytes as an indicator which could evaluate the effects of mutagenicity after in vivo exposure to hexavalent chromium,...
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Selenium Effect on the Frequency of SCEs Induced by Heavy Metals in Human Lymphocytes

Koh DH, Ki NS

  • KMID: 2282457
  • Korean J Prev Med.
  • 1990 Mar;23(1):1-10.
The protective effect of sodium selenite (Na2SeO3) against the cytogenetic toxicity of heavy metals was investigated on human whole-blood cultures in relation to induction of sister chromatid exchange(SCE) in secondary...
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Effect of Several Heavy Metals on the Frequencies of Sister Chromatid Exchanges and Chromosomal Aberrations in Human Lymphocytes

Jung CD, Lee JS, Koh DH, Ki NS, Hwang ID

  • KMID: 2282427
  • Korean J Prev Med.
  • 1989 Mar;22(1):116-124.
To assay the cytogenetic toxicity of NiCl, K2Cr2O7CdC12, and HgC12, the frequencies of sister chromatid exchanges(SCEs) and chromosomal aberrations were observed in the metaphase chromosomes of the human lymphocytes which...
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Effects of Mitomycin C on Sister Chromatid Exchanges in Cultured Human Lympocytes

Hwang ID, Ki NS, Lee JS, Kim NS, Mun TL

  • KMID: 2282244
  • Korean J Prev Med.
  • 1986 Nov;19(2):244-251.
Sister chromatid exchanges(SCEs) and cell cycle kinetics were proposed as a sensitive and quantitative assay for mutagenicity and cytotoxicity in short-term cultures of phytohemagglutinin(PHA)-stimulated human lymphocytes. Therefore, this study was...
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Sister Chromatid Exchanges in Lymphocytes on Normal Human Blood culture with Mercury chloride or Methylmercury Chloride

Koh DH

  • KMID: 2282201
  • Korean J Prev Med.
  • 1984 Sep;17(1):245-250.
Reciprocal exchanges of DNA in sister chromatids (SCEs) are induced by various carcinogens and mutagens, although the quantitative relationship between the number of mutations and SCEs induced varies among chemicals....
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