Korean J Prev Med.  1989 Mar;22(1):116-124.

Effect of Several Heavy Metals on the Frequencies of Sister Chromatid Exchanges and Chromosomal Aberrations in Human Lymphocytes

Affiliations
  • 1Department of Preventive Medicine and Pblic Health, Chonbuk National University College of Medicine, Korea.

Abstract

To assay the cytogenetic toxicity of NiCl, K2Cr2O7CdC12, and HgC12, the frequencies of sister chromatid exchanges(SCEs) and chromosomal aberrations were observed in the metaphase chromosomes of the human lymphocytes which were cultured with above materials. The frequencies of SCEs are dose-dependently increased by all materials in this experiment. Chromosomal aberrations, especially gap and break, are increased by the nickel and chromic compounds, while not significantly increased by the cadmium and mercurial compounds. This results indicate the dose dependent relationship between the frequencies of SCEs and the concentrations of the heavy metals, but the increasing rates of the SCEs induced by the heavy metals are less sensitive than other mutagens or carcinogens which were confirmed.


MeSH Terms

Cadmium
Carcinogens
Chromatids
Chromosome Aberrations*
Cytogenetics
Humans
Humans*
Lymphocytes*
Metals, Heavy*
Metaphase
Mutagens
Nickel
Siblings*
Sister Chromatid Exchange*
Cadmium
Carcinogens
Metals, Heavy
Mutagens
Nickel
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