- Poorly-Controlled Type 1 Diabetes Mellitus Impairs LH-LHCGR Signaling in the Ovaries and Decreases Female Fertility in Mice
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Lee J, Lee HC, Kim SY, Cho GJ, Woodruff T
- KMID: 2450407
- Yonsei Med J.
- 2019 Jul;60(7):667-678.
- doi: 10.3349/ymj.2019.60.7.667
PURPOSE: The aim of this study was to investigate how type I diabetes mellitus (T1D) affects the folliculogenesis and oocyte development, fertilization, and embryo development. MATERIALS AND METHODS: A comparative animal... -
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- Various macromolecules in in vitro growth medium influence growth, maturation, and parthenogenetic development of pig oocytes derived from small antral follicles
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Lee H, Lee Y, Lee J, Lee GS, Lee ST, Lee E
- KMID: 2451642
- Korean J Vet Res.
- 2019 Jun;59(2):81-88.
- doi: 10.14405/kjvr.2019.59.2.81
This study was performed to examine the effects of various macromolecules in in vitro growth (IVG) media on the growth, maturation, and parthenogenesis (PA) of pig oocytes derived from small... -
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- Anaplastic Large Cell Lymphoma with Massive Eosinophilia and Complex Karyotype Initially Misdiagnosed as Chronic Eosinophilic Leukemia
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So MK, Park S, Cho MS, Mun YC, Huh J
- KMID: 2407563
- Lab Med Online.
- 2018 Apr;8(2):56-61.
- doi: 10.3343/lmo.2018.8.2.56
We report a patient with massive eosinophilia and a complex karyotype that was initially misdiagnosed as chronic eosinophilic leukemia (CEL), but later diagnosed as anaplastic large cell lymphoma (ALCL) masked... -
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- Clinicopathological Characteristics of Hyperdiploidy with High-Risk Cytogenetics in Multiple Myeloma
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Yang N, Mun YC, Seong CM, Huh HJ, Huh J
- KMID: 2403362
- Ann Lab Med.
- 2018 Mar;38(2):160-164.
- doi: 10.3343/alm.2018.38.2.160
In multiple myeloma (MM), hyperdiploidy (HD) is known to impart longer overall survival. However, it is unclear whether coexistent HD ameliorates the adverse effects of known high-risk cytogenetics in MM... -
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- The association of follicular fluid volume with human oolemma stretchability during intracytoplasmic sperm injection
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Inoue T, Yamashita , Tsujimoto , Yamamoto S, Taguchi S, Hirao K, Uemura M, Ikawa K, Miyazaki K
- KMID: 2390490
- Clin Exp Reprod Med.
- 2017 Sep;44(3):126-131.
- doi: 10.5653/cerm.2017.44.3.126
OBJECTIVE: Oocyte degeneration often occurs after intracytoplasmic sperm injection (ICSI), and the risk factor is low-quality oocytes. The follicular fluid (FF) provides a crucial microenvironment for oocyte development. We investigated... -
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- Frequency and Distinct Characteristics of Acute Myeloid Leukemia Lacking HLA-DR and CD34 Expression: Features Intermediate between Typical Acute Myeloid Leukemia and Acute Promyelocytic Leukemia
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Lee HY, Cho YU, You E, Jang S, Seo EJ, Park CJ
- KMID: 2383088
- Lab Med Online.
- 2017 Jul;7(3):103-110.
- doi: 10.3343/lmo.2017.7.3.103
BACKGROUND: The objective of this study was to investigate the frequency and characteristics of HLA-DRâ»/CD34â» acute myeloid leukemia (AML) also known as acute promyelocytic leukemia (APL)-like AML. METHODS: This study included... -
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- The effects of different types of media on in vitro maturation outcomes of human germinal vesicle oocytes retrieved in intracytoplasmic sperm injection cycles
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Fesahat F, Dehghani Firouzabadi R, Faramarzi , Khalili MA
- KMID: 2405154
- Clin Exp Reprod Med.
- 2017 Jun;44(2):79-84.
- doi: 10.5653/cerm.2017.44.2.79
OBJECTIVE: Optimizing in vitro maturation (IVM) media to achieve better outcomes has been a matter of interest in recent years. The aim of this prospective clinical trial was to investigate... -
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- Dysregulation of Telomere Lengths and Telomerase Activity in Myelodysplastic Syndrome
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Park HS, Choi J, See CJ, Kim JA, Park SN, Im K, Kim SM, Lee DS, Hwang SM
- KMID: 2369744
- Ann Lab Med.
- 2017 May;37(3):195-203.
- doi: 10.3343/alm.2017.37.3.195
BACKGROUND: Telomere shortening is thought to be involved in the pathophysiology of myeloid malignancies, but telomere lengths (TL) during interphase and metaphase in hematopoietic malignancies have not been analyzed. We... -
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- Effects of sperm insemination on the final meiotic maturation of mouse oocytes arrested at metaphase I after in vitro maturation
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Yoon J, Juhn KM, Yoon SH, Ko Y, Lim JH
- KMID: 2408582
- Clin Exp Reprod Med.
- 2017 Mar;44(1):15-21.
- doi: 10.5653/cerm.2017.44.1.15
OBJECTIVE: The aims of this study were to investigate whether fertilization could induce the resumption of meiosis in mouse oocytes arrested at metaphase I (MI) after in vitro maturation (IVM),... -
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- The p90 ribosomal S6 kinase 2 specifically affects mitotic progression by regulating the basal level, distribution and stability of mitotic spindles
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Park YY, Nam HJ, Do M, Lee JH
- KMID: 2361537
- Exp Mol Med.
- 2016 Aug;48(8):e250.
- doi: 10.1038/emm.2016.61
RSK2, also known as RPS6KA3 (ribosomal protein S6 kinase, 90 kDa, polypeptide 3), is a downstream kinase of the mitogen-activated protein kinase (MAPK) pathway, which is important in regulating survival, transcription,... -
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- A retrospective analysis of cytogenetic alterations in patients with newly diagnosed multiple myeloma: a single center study in Korea
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Li S, Lim HH, Woo KS, Kim SH, Han JY
- KMID: 2309214
- Blood Res.
- 2016 Jun;51(2):122-126.
- doi: 10.5045/br.2016.51.2.122
BACKGROUND: The accurate identification of cytogenetic abnormalities in multiple myeloma (MM) has become more important over recent years for the development of new diagnostic and prognostic markers. In this study,... -
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- Vitrification, in vitro fertilization, and development of Atg7 deficient mouse oocytes
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Bang S, Lee GK, Shin H, Suh CS, Lim HJ
- KMID: 2161356
- Clin Exp Reprod Med.
- 2016 Mar;43(1):9-14.
- doi: 10.5653/cerm.2016.43.1.9
OBJECTIVE: Autophagy contributes to the clearance and recycling of macromolecules and organelles in response to stress. We previously reported that vitrified mouse oocytes show acute increases in autophagy during warming.... -
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- A new mosaic der(18)t(1;18)(q32.1;q21.3) with developmental delay and facial dysmorphism
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Choi YJ, Shin E, Jo TS, Moon JH, Lee SM, Kim JH, Oh JW, Kim CR, Seol IJ
- KMID: 2155928
- Korean J Pediatr.
- 2016 Feb;59(2):91-95.
- doi: 10.3345/kjp.2016.59.2.91
We report the case of a 22-month-old boy with a new mosaic partial unbalanced translocation of 1q and 18q. The patient was referred to our Pediatric Department for developmental delay.... -
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- The potential role of granulosa cells in the maturation rate of immature human oocytes and embryo development: A co-culture study
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Jahromi BN, Mosallanezhad Z, Matloob N, Davari M, Ghobadifar MA
- KMID: 2069036
- Clin Exp Reprod Med.
- 2015 Sep;42(3):111-117.
- doi: 10.5653/cerm.2015.42.3.111
OBJECTIVE: In order to increase the number of mature oocytes usable for intracytoplasmic sperm injection (ICSI), we aimed to investigate the effect of co-culturing granulosa cells (GCs) on human oocyte... -
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- Cryptic Insertion of the BCR Gene at 9q34 in Philadelphia-Negative Chronic Myelogenous Leukaemia
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Kim HJ, Ji M, Kim H, Moon HW, Hur M, Yun YM
- KMID: 2200374
- J Lab Med Qual Assur.
- 2015 Jun;37(2):110-114.
- doi: 10.15263/jlmqa.2015.37.2.110
Chronic myelogenous leukaemia (CML) is a myeloproliferative neoplasm that is almost always characterised by the presence of t(9;22)(q34;q11.2). Approximately 5% to 10% of CML patients lack cytogenetic evidence of t(9;22)(q34;q11.2)... -
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- Evaluation of the genotoxicity of ginseng leaf extract UG0712
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Kim JY, Ri Y, Do SG, Lee YC, Park SJ
- KMID: 2312121
- Lab Anim Res.
- 2014 Sep;30(3):104-111.
- doi: 10.5625/lar.2014.30.3.104
Although ginseng (genus Panax) leaf extract contains high concentrations of bioactive constituents, its effects have been reported in few preclinical studies, and information regarding its toxicity is not sufficient to... -
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- In vitro growth of mouse preantral follicles: effect of animal age and stem cell factor/insulin-like growth factor supplementation
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Jee BC, Kim JH, Park DH, Youm H, Suh CS, Kim SH
- KMID: 2167508
- Clin Exp Reprod Med.
- 2012 Sep;39(3):107-113.
- doi: 10.5653/cerm.2012.39.3.107
OBJECTIVE: To determine whether animal age impacts in vitro preantral follicle growth. Effects of hCG, stem cell factor (SCF), and/or insulin-like growth factor (IGF) supplementation in growth medium were also... -
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- Ring Chromosome 5 in Acute Myeloid Leukemia Defined by Whole-genome Single Nucleotide Polymorphism Array
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Huh J, Mun YC, Chung WS, Seong CM
- KMID: 1380093
- Ann Lab Med.
- 2012 Jul;32(4):307-311.
- doi: 10.3343/alm.2012.32.4.307
Chromosomes forming a corresponding ring cannot be clearly defined by conventional cytogenetics or FISH. Karyotypic analyses using whole-genome single nucleotide polymorphism arrays (SNP-A) may result in the identification of previously... -
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- Function of the pentose phosphate pathway and its key enzyme, transketolase, in the regulation of the meiotic cell cycle in oocytes
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Kim Y, Kim EY, Seo YM, Yoon TK, Lee WS, Lee KA
- KMID: 1743692
- Clin Exp Reprod Med.
- 2012 Jun;39(2):58-67.
- doi: 10.5653/cerm.2012.39.2.58
OBJECTIVE: Previously, we identified that transketolase (Tkt), an important enzyme in the pentose phosphate pathway, is highly expressed at 2 hours of spontaneous maturation in oocytes. Therefore, this study was... -
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- Sole Trisomy 22 Not Associated with inv(16) in Myelodysplastic Syndrome
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Hahm C, Hwang Y, Mun YC, Seong CM, Chung WS, Huh J
- KMID: 2134949
- Ewha Med J.
- 2012 Mar;35(1):62-64.
- doi: 10.12771/emj.2012.35.1.62
Trisomy 22 is closely associated with inv(16) or t(16;16) and could be a marker of cryptic rearrangement of CBFB/MYH11 in acute myeloid leukemia (AML). Trisomy 22 not associated with CBFB/MYH11... -
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