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Impact of microbiota in colorectal carcinogenesis: lessons from experimental models

Yu LC, Wei SC, Ni YH

A role of gut microbiota in colorectal cancer (CRC) growth was first suggested in germ-free rats almost 50 years ago, and the existence of disease-associated bacteria (termed pathobionts) had becoming...
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Genome Shuffling of Mangrove Endophytic Aspergillus luchuensis MERV10 for Improving the Cholesterol-Lowering Agent Lovastatin under Solid State Fermentation

El-Gendy M, Al-Zahrani HAA, El-Bondkly AMA

In the screening of marine mangrove derived fungi for lovastatin productivity, endophytic Aspergillus luchuensis MERV10 exhibited the highest lovastatin productivity (9.5 mg/gds) in solid state fermentation (SSF) using rice bran....
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Point Mutation of Hoxd12 in Mice

Cho KW, Kim JY, Cho JW, Cho KH, Song CW, Jung HS

PURPOSE: Genes of the HoxD cluster play a major role in vertebrate limb development, and changes that modify the Hoxd12 locus affect other genes also, suggesting that HoxD function is...
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Polymorphism in the DNA Repair Gene XRCC1 Associated with Squamous Cell Carcinoma and Basal Cell Carcinoma of the Skin in Koreans

Kang SY, Lee GG, Shim JY, Chung YG, Kim NK, Min WK

  • KMID: 2098428
  • J Korean Soc Plast Reconstr Surg.
  • 2006 Jul;33(4):433-439.
PURPOSE: DNA in most cell is regularly damaged by endogenous and exogenous mutagens. Unrepaired damage resulted in apoptosis or may lead to unregulated cell growth and cancer. Inheritance of genetic...
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Effects of Smoking and Age on SCE Frequency Reflecting DNA Damage of Human Lymphocytes in Elderly Koreans

Lee JH, Kang MH

  • KMID: 1618398
  • Korean J Nutr.
  • 2003 Oct;36(8):851-858.
Sister chromatid exchange (SCE) has recently become a common cytogenic assay system for detecting exposure to chemical mutagens and carcinogens. One application of SCE is the monitoring of populations believed...
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A Case of Desanctis-Cacchione Syndrome

Kim JS, Suh ES

  • KMID: 2177064
  • J Korean Child Neurol Soc.
  • 2002 Nov;10(2):383-387.
Xeroderma pigmentosum is autosomal recessive, degenerative disease generated by abnormal repair of DNA damaged by ultraviolet radiation and environmental mutagens. DeSanctis-Cacchione syndrome is the most severe form of xeroderma pigmentosum...
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CYP2D6 and NAT2 Polymorphism in HBV Associated in Hepatocellular Carcinoma Patients in Korea

Shin DI, Lee KG, Lee KS, Cho YH

  • KMID: 1940657
  • J Korean Surg Soc.
  • 2002 Feb;62(2):150-156.
PURPOSE: CYP2D6 and N-acetyltransferase (NAT2) are polymorphic enzymes which are expressed in the hepatocyte in a genotype-determined manner. They are known to be involved in the inactivation and activation of...
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Expression of TIMP1, TIMP2 Genes by Ionizing Radiation

Park KK, Jin JS, Park KY, Lee YH, Kim SY, Noh YJ, Ahn SD, Kim JH, Choi EK, Chang H

  • KMID: 2097164
  • J Korean Soc Ther Radiol Oncol.
  • 2001 Jun;19(2):171-180.
PURPOSE: Expression of TIMP, intrinsic inhibitor of MMP, is regulated by signal transduction in response to genotoxins and is likely to be an important step in metastasis, angiogenesis and wound...
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Fanconi anemia screening by diepoxybutane and mitomicin C tests in Korean children with bone marrow failure syndromes

Kook H, Cho D, Cho SH, Hong WP, Kim CJ, Park JY, Yoon WS, Ryang DW, Hwang TJ

Fanconi anemia (FA) is an autosomal recessive disorder of progressive bone marrow failure in patients with congenital malformations. FA is different from acquired aplastic anemia (AA) in terms of...
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Effect of Scutellaria baicalensis Extract on the Immune Functions, Microbial Growth and Mutagenicity

Lee JH, Shin SJ, Moon Y

  • KMID: 1928286
  • Korean J Immunol.
  • 1998 Sep;20(3):343-348.
Scute/larisa baica/ensis (SB) has been used as a folk medicine for curing ulcer, inflammation and infection. However, surprisingly little has been done to develop and exploit SB's immunomodulating, anti- inflammatory...
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A Case of Double Primary Cancer Associated with a Low Junction of the Cystic Duct

Kim GS, Jung SH, Kim SJ, Kang SS, Kae SH, Lee J, Kwak ST, Joo SA, Park HR, Sohn JH

  • KMID: 1865249
  • Korean J Gastrointest Endosc.
  • 1998 Aug;18(4):630-636.
Recently it has been discovered that anomalous union of pancreaticobiliary duct (AUPBD) may play an important role in the pathogenesis of bile duct cancer. Similar to this fact, there were...
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Chromosome Breakage Test for the Diagnosis of Fanconi's Anemia

Ryang DW, Cho D, Hong WP, Kook H, Hwang TJ

  • KMID: 1863298
  • Korean J Clin Pathol.
  • 1998 Mar;18(1):101-106.
BACKGROUND: Fanconi's anemia (FA) is an autosomal recessive disease characterized by aplastic anemia, pre-malignancy, congenital malformations and chromosome breakage syndromes. As up to 30% of patients have no detectable congenital...
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A Clinical Study of Fanconi's Anemia

Cho SH, Kook H, Kim GM, Yoon WS, Cho TH, Hwang TJ

  • KMID: 2072456
  • Korean J Pediatr Hematol Oncol.
  • 1997 Apr;4(1):70-77.
BACKGROUND: Fanconi's anemia(FA) is an autosomal recessive disease characterized by aplastic anemia and congenital malformations. As up to 30% of patients have no physical stigmata, the modern diagnosis of FA...
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Effect of Several Heavy Metals on the Frequencies of Sister Chromatid Exchanges and Chromosomal Aberrations in Human Lymphocytes

Jung CD, Lee JS, Koh DH, Ki NS, Hwang ID

  • KMID: 2282427
  • Korean J Prev Med.
  • 1989 Mar;22(1):116-124.
To assay the cytogenetic toxicity of NiCl, K2Cr2O7CdC12, and HgC12, the frequencies of sister chromatid exchanges(SCEs) and chromosomal aberrations were observed in the metaphase chromosomes of the human lymphocytes which...
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Cytogenetic Effects on Mouse Fetus of Acute and Chronic Transplacental In Vivo Exposure to Carbon Monoxide: Induction of Micronuclei and Sister Chromatid Exchanges

Kwak HM, Yang YH, Lee MS

Carbon monoxide gas is found in the atmosphere whenever society has become industrialized. In addition to the fact that Korea has become industrialized, bituminous coal is used to heat homes...
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Sister Chromatid Exchanges in Lymphocytes on Normal Human Blood culture with Mercury chloride or Methylmercury Chloride

Koh DH

  • KMID: 2282201
  • Korean J Prev Med.
  • 1984 Sep;17(1):245-250.
Reciprocal exchanges of DNA in sister chromatids (SCEs) are induced by various carcinogens and mutagens, although the quantitative relationship between the number of mutations and SCEs induced varies among chemicals....
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The Cytogenetic Effects of Mutagens on Mouse Offspring

Sohn SK, Hahn SS

When chemical agents penetrate the placenta, it is potentially hazardous to the embryo because the embryonic stage is known to be extremely sensitive to various toxic agents. It has been...
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The Production of Micronuclei from Chromosome Aberrations by Chemical Carcinogens in Mice

Hahn S, Kim DS

The effect of four alkylating agents (MMS, EMs, DMN, DEM), under various con centrations on mouse bone marrow erythrocytes, were studied by means of the micronucleus test. The results obtained...
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