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Protein Expression of Cyclin B1, Transferrin Receptor, and Fibronectin Is Correlated with the Prognosis of Adrenal Cortical Carcinoma

Moon SJ, Kim JH, Kong SH, Shin CS

BACKGROUND: Adrenal cortical carcinoma (ACC) is a rare cancer with a variable prognosis. Several prognostic factors of ACC have been previously reported, but a proteomic analysis has not yet been...
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Genistein Inhibits Proliferation of BRCA1 Mutated Breast Cancer Cells: The GPR30-Akt Axis as a Potential Target

Kim GY, Suh J, Jang JH, Kim DH, Park OJ, Park SK, Surh YJ

BACKGROUND: BRCA1 mutated breast cancer cells exhibit the elevated cell proliferation and the higher metastatic potential. G protein-coupled receptor 30 (GPR30) has been shown to regulate growth of hormonally responsive...
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Helicobacter pylori inhibited cell proliferation in human periodontal ligament fibroblasts through the Cdc25C/CDK1/cyclinB1 signaling cascade

Li H, Liang D, Hu N, Dai X, He J, Zhuang H, Zhao W

PURPOSE: Several studies have shown that the oral cavity is a secondary location for Helicobacter pylori colonization and that H. pylori is associated with the severity of periodontitis. This study...
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Discovery of an Indirubin Derivative as a Novel c-Met Kinase Inhibitor with In Vitro Anti-Tumor Effects

Ndolo KM, An SJ, Park KR, Lee HJ, Yoon KB, Kim YC, Han SY

The c-Met protein is a receptor tyrosine kinase involved in cell growth, proliferation, survival, and angiogenesis of several human tumors. Overexpression of c-Met has been found in gastric cancers and...
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A Novel Germline Mutation in BRCA1 Causes Exon 20 Skipping in a Korean Family with a History of Breast Cancer

Yoon KA, Kong SY, Lee EJ, Cho JN, Chang S, Lee ES

Germline mutations in the BRCA1 and BRCA2 genes are strong genetic factors for predispositions to breast, ovarian, and other related cancers. This report describes a family with a history of...
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Cellular Effects of Troglitazone on YD15 Tongue Carcinoma Cells

Ta Thi L, Yoo H

An FDA approved drug for the treatment of type II diabetes, Troglitazone (TRO), a peroxisome proliferator–activated receptor gamma agonist, is withdrawn due to severe idiosyncratic hepatotoxicity. In the search for...
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Expression of Cyclin A, B1, D1, D3, and E in Non-Small Lung Cancers

Ha SY, Kim HK, Im JS, Cho HY, Chung DH, An J

PURPOSE: Cyclins, and their associated cyclin dependent kinases, regulate progression of the cell cycle through the G1 phase and into the S-phase during the DNA replication process. Cyclin E regulation...
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Ethanol Elicits Inhibitory Effect on the Growth and Proliferation of Tongue Carcinoma Cells by Inducing Cell Cycle Arrest

Le TD, Do TA, Yu R, Yoo H

Cellular effects of ethanol in YD-15 tongue carcinoma cells were assessed by MTT assay, caspase activity assay, Western blotting and flow cytometry. Ethanol inhibited the growth and proliferation of YD-15...
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The Bacterial Protein Azurin Enhances Sensitivity of Oral Squamous Carcinoma Cells to Anticancer Drugs

Choi JH, Lee MH, Cho YJ, Park BS, Kim S, Kim GC

PURPOSE: Surgical therapy is the primary treatment for oral cancer, but it can cause facial distortion. Therefore, if anticancer drugs are effective against oral cancer, they may be used preferentially....
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Overexpressions of Cyclin B1, cdc2, p16 and p53 in Human Breast Cancer: The Clinicopathologic Correlations and Prognostic Implications

Chae SW, Sohn JH, Kim DH, Choi YJ, Park YL, Kim K, Cho YH, Pyo JS, Kim JH

PURPOSE: The molecular mechanisms that are responsible for the initiation and progression of breast cancers are largely unknown. This study was to analyze the cyclin B1, cdc2, p53 and p16...
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Sunitinib Malate Synergistically Potentiates Anti-Tumor Effect of Gemcitabine in Human Bladder Cancer Cells

Yoon CY, Lee JS, Kim BS, Jeong SJ, Hong SK, Byun SS, Lee SE

  • KMID: 2315651
  • Korean J Urol.
  • 2011 Jan;52(1):55-63.
PURPOSE: Sunitinib malate (Sutent; Pfizer, New York, NY, USA) is a highly selective multi-targeted agent and has been reported to have potent anti-tumor effects against various tumors, including renal cell...
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The Expression of Hypoxia Inducible Factor-1alpha and Its Correlation with the Expressions of Cyclin A1 and Cyclin B1 and the Clinicopathologic Factors of Uterine Cervical Carcinoma

Pyo JY, Cho JH, Kim H, Park JP, Kim YT, Cho NH

BACKGROUND: Hypoxia inducible factor-1alpha(HIF-1alpha) is a transcription factor for various target genes that are involved in adapting cells to hypoxia. It promotes cell proliferation and survival via modulation of such...
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Propofol-induced Immediate Early Gene Expression in Human Neuroblastoma Cell Lines

Kim DI, Kim JR, Kim SY

BACKGROUND: General anesthetics were known to induce expression of immediate early genes (IEGs), including c-fos and c-jun. However, mechanisms of IEG induction by general anesthetics were not fully understood. METHODS: IEG...
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Treatment with sodium butyrate and rapamycin inhibit growth of human cervical cancer cells

Jeon YJ, Cho CH, Shin SJ, Kwon SH, Cha SD

  • KMID: 2244544
  • Korean J Gynecol Oncol.
  • 2007 Sep;18(3):165-171.
OBJECTIVE: To evaluate whether mTOR inhibition by rapamycin can enhance the inhibitory effect of sodium butyrate, a histone deacetylase (HDAC) inhibitor on human cervical cancer cell line HeLa. METHODS: Cervical...
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Indole-3-carbinol and genistein inhibit growth of human uterine leiomyoma cells

Jeong HW, Kim YO, Shin SJ, Kwon SH, Cha SD, Cho CH

  • KMID: 2077761
  • Korean J Obstet Gynecol.
  • 2007 Jun;50(6):880-886.
OBJECTIVE: To determine whether Indole-3-carbinol (I3C) can enhance the inhibitory effect of genistein on a human uterine leiomyoma cells. METHODS: Five uterine leiomyoma tissues were obtained from hysterectomies conducted on...
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Augmentation of Sodium Butyrate-induced Apoptosis by Phosphatidylinositol 3-kinase Inhibition in the Human Cervical Cancer Cell-line

Park JK, Cho CH, Ramachandran S, Shin SJ, Kwon SH, Kwon SY, Cha SD

  • KMID: 2270824
  • Cancer Res Treat.
  • 2006 Apr;38(2):112-117.
PURPOSE: Sodium butyrate (NaBT) is principally a histone deacetylase (HDAC) inhibitor, and it has the potential to arrest HPV-positive carcinoma cells at the G1 to S phase transition of the...
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Expression of Anaphase Promoting Complex in Surgically Resected Squamous Cell Carcinoma and Adenocarcinoma of the Lung

Song JS, Jung SH, Eom M, Yi SY, Park KH, Kang Y, Kim HY

  • KMID: 1593163
  • Korean J Pathol.
  • 2006 Feb;40(1):52-59.
BACKGROUND: The anaphase promoting complex (APC) promotes the degradation of mitotic cyclins as well as other substrates involved in sister chromatid adhesion. This study was carried out to examine the...
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Differential protein expression of etoposide-treated CaSki cervical carcinoma cells

Lee SB, Bae JS, Kim JJ, Tong SY, Yim EK, Lee KH, Kim CJ, Um SJ, Park JS

  • KMID: 2143540
  • Korean J Gynecol Oncol.
  • 2005 Dec;16(4):333-346.
OBJECTIVE: This study was designed to examine the pharmaco-dynamic pattern of proteomic expression in cervical carcinoma cells (CaSki cell line; HPV-16 positive) after in vitro treatment by the etoposide. METHODS: We...
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Relationship between the expression of cyclin B1, D1 and the various prognostic factors in ovarian carcinoma

Kim HY, Kim JW, Kim YT, Kang MH, Kim JH, Kim SH, Kim SW, Yoon BS

  • KMID: 2272740
  • Korean J Obstet Gynecol.
  • 2005 Nov;48(11):2670-2681.
OBJECTIVE: The objective of this study was to evaluate the relationship between the expression of cyclin B1, D1 and the various prognostic factors in ovarian carcinoma. METHODS: In this study, fresh...
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Cyclin B1 and D1 expression in invasive cervical cancer

Kim YT, Zhao M, Kim HY, Kang MH, Kim JW, Kim SH, Kim JH, Kim SW, Yoon BS

  • KMID: 1575056
  • Korean J Gynecol Oncol.
  • 2005 Sep;16(3):256-263.
OBJECTIVE: Cyclin is a family of regulatory proteins that play a key role in controlling the cell cycle. Abnormalities of cell cycle regulators, including cyclins and cyclin dependent kinases (CDKs),...
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