J Lung Cancer.  2012 Jun;11(1):33-37. 10.6058/jlc.2012.11.1.33.

Expression of Cyclin A, B1, D1, D3, and E in Non-Small Lung Cancers

• Ha SY
• Kim HK
• Im JS
• Cho HY
• Chung DH
• An J

• KMID: 2199874
• DOI: http://doi.org/10.6058/jlc.2012.11.1.33

Abstract

PURPOSE
Cyclins, and their associated cyclin dependent kinases, regulate progression of the cell cycle through the G1 phase and into the S-phase during the DNA replication process. Cyclin E regulation is an important event in cell proliferation. Despite its importance, abnormalities of these genes and their protein products have yet to be found in lits asoociation with lung cancer.
MATERIALS AND METHODS
The relationships between expression of cyclin A, cyclin B1, cyclin D1, cyclin D3, and cyclin E and clinicopathologic factors were investigated in 103 cases with non-small cell carcinomas, using immunohistochemical analysis.
RESULTS
The positive immunoreactivity was observed in 51 cases (50%) for cyclin A, 33 cases (32%) for cyclin B1, 83 cases (81%) for cyclin D1, 19 cases (18%) for cyclin D3, and 11 cases (11%) for cyclin E. Expression of cyclin E was significant for lymph node metastasis (p=0.004, Chi-square test). There was no relationship between cyclin A, B1, D1, and E and histological typing, tumor size, lymph node metastasis, or pathological tumor, node and metastasis staging.
CONCLUSION
These findings suggest that the expression of cyclin E played a role, to some degree, in the lymph node metastasis.

Keyword

Cyclins; Lung neoplasms; Squamous cell carcinoma; Adenocarcinoma

MeSH Terms

Adenocarcinoma
Carcinoma, Squamous Cell
Cell Cycle
Cell Proliferation
Cyclin A
Cyclin B1
Cyclin D1
Cyclin D3
Cyclin E
Cyclin-Dependent Kinases
Cyclins
DNA Replication
G1 Phase
Lung
Lung Neoplasms
Lymph Nodes
Neoplasm Metastasis
Cyclin A
Cyclin B1
Cyclin D1
Cyclin D3
Cyclin E
Cyclin-Dependent Kinases
Cyclins

Figure

• 

  Fig. 1 Immunohistochemical staining of cyclin D1 and E. Positive expression of cyclin D1 showed tumor nuclei in squamous cell carcinoma (A) and adenocarcinoma (B). Cyclin E was positively stained in squamous cell carcinoma (C) and adenocarcinoma (D) (A, B, cyclin D1; C, D, cyclin E; ×400).

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