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Usefulness of BRAF VE1 immunohistochemistry in non–small cell lung cancers: a multi-institutional study by 15 pathologists in Korea

Chang S, Choi YL, Shim HS, Lee GK, Ha SY, Korean Cardiopulmonary Pathology Study Group

Background: Next-generation sequencing (NGS) is an approved test to select patients for BRAF V600E targeted therapy in Korea. However, the high cost, long turnaround times, and the need for sophisticated...
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Prognostic Value of Sarcopenia and Myosteatosis in Patients with Resectable Pancreatic Ductal Adenocarcinoma

Kim DW, Ahn H, Kim KW, Lee SS, Kim HJ, Ko Y, Park T, Lee J

Objective: The clinical relevance of myosteatosis has not been well evaluated in patients with pancreatic ductal adenocarcinoma (PDAC), although sarcopenia has been extensively researched. Therefore, we evaluated the prognostic value...
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Scalp metastasis from an adenocarcinoma of the lung mimicking a cystic mass: case report and literature review

Kim HK, Kang SH, Kim WS, Kang SH, Kim WJ, Kim HS, Bae TH

A 67-year-old man visited our plastic surgery clinic complaining of a palpable protruding mass (2.0 × 2.5 cm) in the right occipital region. To establish an appropriate treatment plan for...
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Single-Stage Posterior Approach for the En Bloc Resection and Spinal Reconstruction of T4 Pancoast Tumors Invading the Spine

Wang Z, Truong VT, Liberman M, Al-Shakfa F, Yuh SJ, Soder SA, Wu J, Sunna T, Renaud-Charest , Boubez G, Shedid D

Study Design: Retrospective cohort study. Purpose: This study aimed to evaluate the outcomes of patients who had T4 Pancoast tumors invading the spine and underwent en bloc resection and spinal stabilization...
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Cytopathologic features of human papillomavirus–independent, gastric-type endocervical adenocarcinoma

Yeo MK, Bae GE, Kim DH, Seong IO, Suh KS

Background: Gastric-type endocervical adenocarcinoma (GEA) is unrelated to human papillomavirus (HPV) infection and is clinically aggressive compared with HPV-associated usual-type endocervical adenocarcinoma (UEA). The cytological diagnosis falls short of a...
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Landscape of EGFR mutations in lung adenocarcinoma: a single institute experience with comparison of PANAMutyper testing and targeted next-generation sequencing

Lee J, Han YB, Kwon HJ, Lee SK, Kim H, Chung JH

Background: Activating mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) are predictive biomarkers for response to EGFR–tyrosine kinase inhibitor (TKI) therapy in lung adenocarcinoma (LUAD). Here,...
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Combination of 18 F-Fluorodeoxyglucose PET/CT Radiomics and Clinical Features for Predicting Epidermal Growth Factor Receptor Mutations in Lung Adenocarcinoma

Li S, Li Y, Zhao M, Wang P, Xin J

Objective: To identify epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma based on 18 F-fluorodeoxyglucose (FDG) PET/CT radiomics and clinical features and to distinguish EGFR exon 19 deletion (19...
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Clinical Comparison of Proximal Gastrectomy With Double-Tract Reconstruction Versus Total Gastrectomy With Roux-en-Y Anastomosis for Siewert Type II/III Adenocarcinoma of the Esophagogastric Junction

Ma X, Zhao M, Wang J, Pan H, Wu J, Xing C

Purpose: The incidence of adenocarcinoma of the esophagogastric junction (AEG) has increased in recent years, and the optimal surgical strategy for AEG remains highly controversial. We aimed to evaluate the...
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Selection Strategies and Practical Application of BRAF V600E-Mutated Non–Small Cell Lung Carcinoma

Hwang I, Choi YL, Lee H, Hwang S, Lee B, Yang H, Chelakkot C, Han J

Purpose The incidence of BRAF V600E mutation in non-small cell lung carcinoma (NSCLC) is lower than 2%, which poses difficulties in finding legitimate patients for targeted therapy. We investigated the predictive...
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Histologic Changes in Non–Small Cell Lung Cancer under Various Treatments: A Comparison of Histology and Mutation Status in Serial Samples

Woo CG, Son SM, Lee HC, Han HS, Lee KH, Kim D, Kim EG, Lee OJ

Purpose Histologic change is a resistant mechanism in lung cancer. The most common histological change is the switch from adenocarcinoma (AdenoCa) to small cell carcinoma (SCC) against to tyrosine kinase inhibitors...
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Should transanal total mesorectal excision be implemented in medium-sized colorectal unit? technical and oncological outcome

Ho Mf, Ng DCK, Lee JFy, Ng SSm

Purpose: This study was performed to evaluate the outcome of implementation of transanal total mesorectal excision (TaTME) for low rectal cancer in a regional hospital and in comparison to laparoscopic...
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A Case of Carcinoma with Sebaceous Differentiation arising in the Patient who was Treated with Parotid Gland Adenocarcinoma

Park S, Yun JH, Go YJ, Jung SY

Sebaceous carcinoma is extremely rare in the parotid gland. Recently, we experienced a case of carcinoma with sebaceous differentiation arising from the parotid gland in patient who was diagnosed as...
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Epidemiology of early esophageal adenocarcinoma

Hang TVP, Spiritos Z, Gamboa AM, Chen Z, Force S, Patel V, Chawla S, Keilin S, Saba NF, El-Rayes B, Cai Q, Willingham FF

Background/Aims: Endoscopic resection has become the preferred treatment approach for select early esophageal adenocarcinoma (EAC); however, the epidemiology of early stage disease has not been well defined. Methods: Surveillance Epidemiology and...
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The clinical outcomes of second-line chemotherapy in patients with advanced pancreatic cancer: a retrospective study

Jung Hy, Lee EM

Background: Despite recent advances in first-line chemotherapy for advanced pancreatic cancer, standard treatment after the failure of initial chemotherapy has not been established. Hence, we aimed to retrospectively analyze the...
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The Clinical Outcomes of Different First-Line EGFR-TKIs Plus Bevacizumab in Advanced EGFR-Mutant Lung Adenocarcinoma

Huang YH, Hsu KH, Chin CS, Tseng JS, Yang TY, Chen KC, Su KY, Yu SL, Chen JJ, Chang GC

Purpose The aim of this study was to investigate the efficacy of various epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitors (TKIs) plus bevacizumab in advanced EGFR-mutant lung adenocarcinoma patients. Materials and Methods From...
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Primary Mucinous Adenocarcinoma of the Lower Eyelid

Choi YS, Jung DH, Chi M

Purpose: We report a case of a primary mucinous adenocarcinoma of the lower eyelid diagnosed in patient with a painless mass. Case summary: A 62-year-old male visited our clinic with a...
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Dome-type carcinoma of the rectum mimicking a submucosal tumor: a case report and literature review

Noh BJ, Park SJ, Jang JY, Kim YW

Dome-type carcinoma (DC) has been recognized as a rare variant of adenocarcinoma, which arises in gutassociated lymphoid tissue. It has a specific morphologic feature of a dome-like protrusion associated with...
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Incidence and predictive factors for recurrent clear cell ovarian carcinoma: results from a single center in Thailand

Hemman W, Rattanaburi A

Objective We aimed to study the incidence and predictive factors of recurrent clear cell ovarian carcinoma (CCC) and evaluate the oncological outcomes after recurrence. Methods This was a retrospective study of 134 CCC...
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Prognosis for Pneumonic-Type Invasive Mucinous Adenocarcinoma in a Single Lobe on CT: Is It Reasonable to Designate It as Clinical T3?

Kim W, Lee SM, Lee JB, Seo JB, Kim HK, Kim J, Lee HY

Objective: To compare pneumonic-type invasive mucinous adenocarcinoma (pIMA) confined to a single lobe with clinical T2, T3, and T4 stage lung cancer without pathological node metastasis regarding survival after curative...
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Colorectal adenocarcinoma with enteroblastic differentiation: diagnostic challenges of a rare case encountered in clinical practice

Abada E, Anaya IC, Abada O, Lebbos A, Beydoun R

Colorectal adenocarcinoma with enteroblastic differentiation (CAED) is a rare subtype of colonic adenocarcinoma characterized by increased α-fetoprotein (AFP) production and the expression of at least one enteroblastic marker including AFP,...
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