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Epstein-Barr Virus-associated Mixed Lymphoepithelioma-like Carcinoma and Adenocarcinoma of the Gall Bladder: An Unusual Entity

Jain N, Goyal S, Sakhuja P, Saluja S

Schmincke described lymphoepithelioma as an undifferentiated carcinoma with abundant lymphoid stroma in the nasopharynx. Tumors with a similar histomorphology in extrapharyngeal areas have been referred to as lymphoepithelioma-like carcinoma (LELC)....
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SMARCA4/BRG1 protein-deficient thoracic tumors dictate re-examination of small biopsy reporting in non–small cell lung cancer

Mehta A, Bansal D, Tripathi R, Jajodia A

Background: SMARCA4/BRG1 protein–deficient lung adenocarcinomas and thoracic sarcoma are recently described entities that lack distinctive histological features, transcription termination factor 1 (TTF1) reactivity, and actionable driver mutations. The current diagnostic...
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How to Combine Diffusion-Weighted and T2-Weighted Imaging for MRI Assessment of Pathologic Complete Response to Neoadjuvant Chemoradiotherapy in Patients with Rectal Cancer?

Jang JK, Lee Cm, Park SH, Kim JH, Kim J, Lim SB, Yu CS, Kim JC

Objective: Adequate methods of combining T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI) to assess complete response (CR) to chemoradiotherapy (CRT) for rectal cancer are obscure. We aimed to determine an...
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Mutations of p53 associated with pancreatic cancer and therapeutic implications

Voutsadakis IA

Pancreatic adenocarcinoma is a malignancy with rising incidence and grim prognosis. Despite improvements in therapeutics for treating metastatic pancreatic cancer, this disease is invariably fatal with survival time less than...
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Gemcitabine and Erlotinib with or without Oxaliplatin in Previously Untreated Advanced Pancreatic Cancer: A Randomized Phase II Trial

Lim SH, Yun J, Lee MY, Kim HJ, Kim KH, Kim SH, Lee SC, Bae SB, Kim CK, Lee N, Lee KT, Park SK, Lee YN, Moon JH

Purpose: Erlotinib has been the only targeted agent to show significantly improved outcomes in pancreatic adenocarcinoma when combined with gemcitabine. We aimed to evaluate whether the addition of oxaliplatin to...
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Correlation of TTF-1 immunoexpression and EGFR mutation spectrum in non–small cell lung carcinoma

Nakra T, Singh V, Nambirajan A, Malik PS, Mohan A, Jain D

Background: Thyroid transcription factor (TTF-1) is a diagnostic marker expressed in 75%–85% of primary lung adenocarcinomas (ACs). Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor...
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Current Status of Mucosal Imaging with Narrow-Band Imaging in the Esophagus

Chiam KH, Shin SH, Choi KC, Leiria F, Militz M, Singh R

Recent advances in endoscopic imaging of the esophagus have revolutionized the diagnostic capability for detecting premalignant changes and early esophageal malignancy. In this article, we review the practical application of...
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Extensive Resection for Treatment of Locally Advanced Primary Mucinous Adenocarcinoma Arising From Fistula-in-Ano

Au J, Hulme-Moir FM, Herd A, Kozman MA

We report a case of a 66-year-old male who presented with a locally advanced primary mucinous adenocarcinoma arising from a fistula-in-ano. The presentation was typical for perianal sepsis and fistula-in-ano...
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A Case of Umbilical Metastasis (Sister Mary Joseph’s Nodule) from Mucinous Ovarian Carcinoma

Kang MJ, Seo JM, Yun SY, Lee JH, Yu DS, Lee YB

  • KMID: 2517151
  • Korean J Dermatol.
  • 2021 Jun;59(5):413-415.
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A Case of Adenocarcinoma Developed in the Terminal Ileum Presenting Elevated Carcinoembryonic Antigen

Lee SH, Lee JG

Malignant neoplasm of the small intestine is a relatively rare disease. Because the early manifestation of symptoms in patients with cancer of the small intestine is non-specific, diagnosis is often...
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Subepithelial Tumor-like Gastric Cancer

Jung K, Park MI

Subepithelial tumor-like gastric cancer (SET-like GC) is a special type of gastric cancer with a relatively low prevalence of approximately 1%. Diagnosing SET-like GC is challenging because the tumor is...
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Papillary Adenocarcinoma

Kim TS, Min BH

Gastric papillary adenocarcinoma is one of the histological variants of gastric cancer that shows more aggressive clinicopathological behavior compared to tubular adenocarcinoma. Previous studies have reported higher lymphovascular and submucosal...
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Impact of diabetes mellitus on morbidity and survival after pancreaticoduodenectomy for malignancy

Deo KB, Kulkarni AA, Kumar-M P, Krishnamurthy G, Shenvi S, Rana SS, Kapoor R, Gupta R

Backgrounds/Aims: Diabetes mellitus (DM) is a known risk factor for morbidity, length of hospital stay, or mortality after surgery, however, its impact on postoperative course and long-term survival after pancreaticoduodenectomy...
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Advances in neoadjuvant therapy for resectable pancreatic cancer over the past two decades

Taboada AGM, Lominchar PL, Roman LM, García-Alfonso P, Martin AJM, Rodriguez JAB, Pascual JMA

In the last two decades, pancreatic cancer has been undergoing important changes in its perioperative management due to the great interest in multidisciplinary management and preoperative multimodal therapy, which in...
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Semi-Quantitative Analysis for Determining the Optimal Threshold Value on CT to Measure the Solid Portion of Pulmonary Subsolid Nodules

Lee S, Lee DH, Lee JH, Lee S, Han K, Park CH, Kim TH

Purpose: This study aimed to investigate the optimal threshold value in Hounsfield units (HU) on CT to detect the solid components of pulmonary subsolid nodules using pathologic invasive foci as...
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Primary Invasive Mucinous Adenocarcinoma of the Lung: Prognostic Value of CT Imaging Features Combined with Clinical Factors

Objective: To investigate the association between CT imaging features and survival outcomes in patients with primary invasive mucinous adenocarcinoma (IMA). Materials and Methods: Preoperative CT image findings were consecutively evaluated in...
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A Case of Simultaneously Diagnosed Lung Adenocarcinoma and Endobronchial Inflammatory Myofibroblastic Tumor with Two Distinct Types of ALK Translocation

Zhao S, Liu W, Li S, Shi T, Chen Q, Li Q, Sun L, Ren D, Song Z, Huang C, Xu S

A 61-year-old male patient was simultaneously diagnosed with lung adenocarcinoma and inflammatory myofibroblastic tumor (IMT). The lung adenocarcinoma and IMT harbored two distinct types of ALK translocation, LOC101927285-ALK, and TPM3-ALK,...
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A case of concomitant EGFR/ALK alteration against a mutated EGFR background in early-stage lung adenocarcinoma

Lee KC, Koh J, Chung DH, Jeon YK

Rare cases of lung adenocarcinoma (LUAD) with concomitant epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) translocation have been reported. However, their clonal and evolutional relationship remains...
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The baseline recurrence risk of patients with intermediate-risk cervical cancer

Yoneoka Y, Kato MK, Tanase Y, Uno M, Ishikawa M, Murakami T, Kato T

Objective This study aimed to investigate the prognosis of patients with intermediate-risk cervical cancer and to evaluate the necessity of adjuvant therapy. Methods We conducted a retrospective chart review of patients with stage...
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Volume and Mass Doubling Time of Lung Adenocarcinoma according to WHO Histologic Classification

Hong JH, Park S, Kim H, Goo JM, Park IK, Kang CH, Kim YT, Yoon SH

Objective: This study aimed to evaluate the tumor doubling time of invasive lung adenocarcinoma according to the International Association of the Study for Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory...
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