- Optimized Image-Based Surrogate Endpoints in Targeted Therapies for Glioblastoma: A Systematic Review and Meta-Analysis of Phase III Randomized Controlled Trials
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Suh CH, Kim HS, Jung SC, Choi CG, Kim SJ, Kim KW
- KMID: 2471813
- Korean J Radiol.
- 2020 Apr;21(4):471-482.
- doi: 10.3348/kjr.2019.0839
OBJECTIVE: We aimed to determine the optimized image-based surrogate endpoints (IBSEs) in targeted therapies for glioblastoma through a systematic review and meta-analysis of phase III randomized controlled trials (RCTs). MATERIALS AND... -
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- Identification of Molecular Signatures in Mild Intrinsic Atopic Dermatitis by Bioinformatics Analysis
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Yin H, Wang S, Gu C
- KMID: 2471339
- Ann Dermatol.
- 2020 Apr;32(2):130-140.
- doi: 10.5021/ad.2020.32.2.130
BACKGROUND: Atopic dermatitis (AD) is recognized as a common inflammatory skin disease and frequently occurred in Asian and Black individuals. OBJECTIVE: Since the limitation of dataset associated with human severe AD,... -
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- Cellular Senescence in Arterial Diseases
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Shimizu I, Minamino T
- KMID: 2470802
- J Lipid Atheroscler.
- 2020 Jan;9(1):79-91.
- doi: 10.12997/jla.2020.9.1.79
Cell-proliferation potency is limited, as cells cannot proceed through the cell cycle continually. Instead, they eventually show an irreversible arrest of proliferation, commonly referred to as cellular senescence. Following the... -
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- Genistein Inhibits Proliferation of BRCA1 Mutated Breast Cancer Cells: The GPR30-Akt Axis as a Potential Target
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Kim GY, Suh J, Jang JH, Kim DH, Park OJ, Park SK, Surh YJ
- KMID: 2468809
- J Cancer Prev.
- 2019 Dec;24(4):197-207.
- doi: 10.15430/JCP.2019.24.4.197
BACKGROUND: BRCA1 mutated breast cancer cells exhibit the elevated cell proliferation and the higher metastatic potential. G protein-coupled receptor 30 (GPR30) has been shown to regulate growth of hormonally responsive... -
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- Chemical Regeneration of Wound Defects: Relevance to the Canine Palatal Mucosa and Cell Cycle Up-Regulation in Human Gingival Fibroblasts
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Lee K, Ben Amara , Lee SC, Leesungbok R, Chung MA, Koo KT, Lee SW
- KMID: 2467059
- Tissue Eng Regen Med.
- 2019 Dec;16(6):675-684.
- doi: 10.1007/s13770-019-00227-6
BACKGROUND: Trichloroacetic acid (TCA) is an agent widely applied in dermatology for skin regeneration. To test whether TCA can offer an advantage for the regeneration of oral soft tissue defects,... -
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- Anti-cancer Activity of Paclitaxel, Lenvatinib and Radiation Combination Therapy on Anaplastic Thyroid Cancer in Vitro and in Vivo
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Jun S, Kim SY, Kim SM, Park KC, Kim HJ, Chang HJ, Lee YS, Chang HS, Park CS
- KMID: 2469230
- Korean J Head Neck Oncol.
- 2019 Nov;35(2):19-25.
- doi: 10.21593/kjhno/2019.35.2.19
BACKGROUND/OBJECTIVES: Although anaplastic thyroid carcinoma (ATC) is rare, it is one of the deadliest forms of thyroid cancer. The fatality rate for ATC is high, and the survival rate at... -
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- Etoposide Induces Mitochondrial Dysfunction and Cellular Senescence in Primary Cultured Rat Astrocytes
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Bang M, Kim DG, Gonzales E, Kwon KJ, Shin CY
- KMID: 2462880
- Biomol Ther.
- 2019 Nov;27(6):530-539.
- doi: 10.4062/biomolther.2019.151
Brain aging is an inevitable process characterized by structural and functional changes and is a major risk factor for neurodegenerative diseases. Most brain aging studies are focused on neurons and... -
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- Three-Dimensional Spheroid Formation of Cryopreserved Human Dental Follicle-Derived Stem Cells Enhances Pluripotency and Osteogenic Induction Properties
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Kim HJ, Sung IY, Cho YC, Kang MS, Rho GJ, Byun JH, Park WU, Son MG, Park BW, Lee HJ, Kang YH
- KMID: 2464071
- Tissue Eng Regen Med.
- 2019 Oct;16(5):513-523.
- doi: 10.1007/s13770-019-00203-0
BACKGROUND: Enhancement and maintenance of the stemness of mesenchymal stem cells (MSCs) is one of the most important factors contributing to the successful in vivo therapeutic application of these cells.... -
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- Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis
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Li N, Piao J, Wang X, Kim KY, Bae JY, Ren X, Lin Z
- KMID: 2460613
- Cancer Res Treat.
- 2019 Oct;51(4):1653-1665.
- doi: 10.4143/crt.2018.544
PURPOSE: This study was aimed to investigate the role of poly(A)-binding protein-interacting protein 1 (Paip1) in cervical carcinogenesis. MATERIALS AND METHODS: The expression of Paip1 in normal cervical epithelial tissues and... -
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- Low Doses of Nonylphenol Promote Growth of Colon Cancer Cells through Activation of ERK1/2 via G Protein‒Coupled Receptor 30
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Xie M, Liang JL, Huang HD, Wang MJ, Zhang T, Yang XF
- KMID: 2460610
- Cancer Res Treat.
- 2019 Oct;51(4):1620-1631.
- doi: 10.4143/crt.2018.340
PURPOSE: Nonylphenol (NP) is an endocrine disruptor found in products such as cleaners, plastics, and detergents. It exerts actions similar to endogenous 17β-estradiol (E2) and is reported to influence various... -
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- De novo transcriptome sequencing and gene expression profiling with/without B-chromosome plants of Lilium amabile
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Park D, Kim JH, Kim NS
- KMID: 2462041
- Genomics Inform.
- 2019 Sep;17(3):e27.
- doi: 10.5808/GI.2019.17.3.e27
Supernumerary B chromosomes were found in Lilium amabile (2n = 2x = 24), an endemic Korean lily that grows in the wild throughout the Korean Peninsula. The extra B chromosomes... -
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- Mesenchymal stem cells in acute myeloid leukemia: a focus on mechanisms involved and therapeutic concepts
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Fathi E, Sanaat Z, Farahzadi
- KMID: 2459381
- Blood Res.
- 2019 Sep;54(3):165-174.
- doi: 10.5045/br.2019.54.3.165
Drug resistance in cancer, especially in leukemia, creates a dilemma in treatment planning. Consequently, studies related to the mechanisms underlying drug resistance, the molecular pathways involved in this phenomenon, and... -
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- In Vitro and In Vivo Study on the Effect of Lysosome-associated Protein Transmembrane 4 Beta on the Progression of Breast Cancer
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Tao D, Liang J, Pan Y, Zhou Y, Feng Y, Zhang L, Xu J, Wang H, He P, Yao J, Zhao Y, Ning Q, Wang W, Jiang W, Zheng J, Wu X
- KMID: 2458859
- J Breast Cancer.
- 2019 Sep;22(3):375-386.
- doi: 10.4048/jbc.2019.22.e43
PURPOSE: Although the effect of lysosome-associated protein transmembrane 4 beta (LAPTM4B) on the proliferation, migration, and invasion of breast cancer (BC) cells has already been studied, its specific role in... -
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- Effects of Oxytocin on Cell Proliferation in a Corticotroph Adenoma Cell Line
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Lim JS, Eom YW, Lee ES, Kwon HJ, Kwon JY, Choi J, Chung CH, Jo YS, Lee EJ
- KMID: 2458633
- Endocrinol Metab.
- 2019 Sep;34(3):302-313.
- doi: 10.3803/EnM.2019.34.3.302
BACKGROUND: Oxytocin (OXT) has been reported to act as a growth regulator in various tumor cells. However, there is a paucity of data on the influence of OXT on cell... -
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- Anti-malarial Drugs Reduce Vascular Smooth Muscle Cell Proliferation via Activation of AMPK and Inhibition of Smad3 Signaling
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Lee H, Han JH, Kim S, Kim S, Cho DH, Woo CH
- KMID: 2458392
- J Lipid Atheroscler.
- 2019 Sep;8(2):267-276.
- doi: 10.12997/jla.2019.8.2.267
OBJECTIVE: The aim of this study was to investigate the effects of 2 anti-malarial drugs, chloroquine (CQ) and hydroxychloroquine (HCQ), on inhibition of vascular smooth muscle cell (VSMC) proliferation both... -
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- Enhanced Anti-Cancer Effects of Conditioned Medium from Hypoxic Human Umbilical Cord–Derived Mesenchymal Stem Cells
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Han KH, Kim AK, Jeong GJ, Jeon HR, Bhang SH, Kim DI
- KMID: 2465899
- Int J Stem Cells.
- 2019 Jul;12(2):291-303.
- doi: 10.15283/ijsc19002
BACKGROUND AND OBJECTIVES: There have been contradictory reports on the pro-cancer or anti-cancer effects of mesenchymal stem cells. In this study, we investigated whether conditioned medium (CM) from hypoxic human... -
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- Therapeutic Targeting of the DNA Damage Response Using an ATR Inhibitor in Biliary Tract Cancer
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Nam AR, Jin MH, Park JE, Bang JH, Oh DY, Bang YJ
- KMID: 2454308
- Cancer Res Treat.
- 2019 Jul;51(3):1167-1179.
- doi: 10.4143/crt.2018.526
PURPOSE: The DNA damage response (DDR) is a multi-complex network of signaling pathways involved in DNA damage repair, cell cycle checkpoints, and apoptosis. In the case of biliary tract cancer... -
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- Jab1 Silencing Inhibits Proliferation and Sensitizes to Cisplatin in Biliary Tract Cancer
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Nam AR, Kim JW, Park JE, Bang JH, Jin MH, Oh DY, Bang YJ
- KMID: 2454281
- Cancer Res Treat.
- 2019 Jul;51(3):886-900.
- doi: 10.4143/crt.2018.375
PURPOSE: Jab1 is a coactivator of c-Jun that enhances the transcriptional function of c-Jun. Jab1 is frequently overexpressed in various cancers and is associatedwith poor prognosis of cancer patients. Thus,... -
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- Helicobacter pylori inhibited cell proliferation in human periodontal ligament fibroblasts through the Cdc25C/CDK1/cyclinB1 signaling cascade
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Li H, Liang D, Hu N, Dai X, He J, Zhuang H, Zhao W
- KMID: 2454084
- J Periodontal Implant Sci.
- 2019 Jun;49(3):138-147.
- doi: 10.5051/jpis.2019.49.3.138
PURPOSE: Several studies have shown that the oral cavity is a secondary location for Helicobacter pylori colonization and that H. pylori is associated with the severity of periodontitis. This study... -
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- Tannic acid-induced apoptosis in FaDu hypopharyngeal squamous cell carcinoma
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Ta LT, Nguyen TT, Yoo H
- KMID: 2452746
- Int J Oral Biol.
- 2019 Jun;44(2):43-49.
- doi: 10.11620/IJOB.2019.44.2.43
Tannic acid (TA) is a water-soluble polyphenol compound found in various herbal plants. We investigated the chemopreventive effects of TA on FaDu hypopharyngeal squamous carcinoma cells. In an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide... -
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