Psychiatry Investig.  2016 Jan;13(1):127-134. 10.4306/pi.2016.13.1.127.

Overexpression of Cell Cycle Proteins of Peripheral Lymphocytes in Patients with Alzheimer's Disease

• Kim H
• Kwon YA
• Ahn IS
• Kim S
• Kim S
• Jo SA
• Kim DK

• KMID: 2316605
• DOI: http://doi.org/10.4306/pi.2016.13.1.127

Abstract

OBJECTIVE
Biological markers for Alzheimer's disease (AD) will help clinicians make objective diagnoses early during the course of dementia. Previous studies have suggested that cell cycle dysregulation begins earlier than the onset of clinical manifestations in AD.
METHODS
We examined the lymphocyte expression of cell cycle proteins in AD patients, dementia controls (DC), and normal controls (NC). One-hundred seventeen subjects (36 AD, 31 DC, and 50 NC) were recruited. The cell cycle proteins CDK2, CDK4, CDK6, cyclin B, and cyclin D were measured in peripheral lymphocytes. Cell cycle protein expression in the three groups was compared after adjusting for age and sex.
RESULTS
The levels of cell cycle proteins CDK2, CDK4, CDK6, cyclin B, and cyclin D were significantly higher in AD patients than in the NC subjects. The DC group manifested intermediate levels of cell cycle proteins compared with the AD patients and the NC subjects. The present study indicates that cell cycle proteins are upregulated in the peripheral lymphocytes of AD patients.
CONCLUSION
Cell cycle dysregulation in peripheral lymphocytes may present a promising starting point for identifying peripheral biomarkers of AD.

Keyword

Biomarker; Cell cycle proteins; Alzheimer's disease; Cyclin; Cyclin-dependent kinase; Peripheral lymphocyte

MeSH Terms

Alzheimer Disease*
Biomarkers
Cell Cycle Proteins*
Cell Cycle*
Cyclin B
Cyclin D
Cyclins
Dementia
Diagnosis
Humans
Lymphocytes*
Cell Cycle Proteins
Cyclin B
Cyclin D
Cyclins