- Chemical Regeneration of Wound Defects: Relevance to the Canine Palatal Mucosa and Cell Cycle Up-Regulation in Human Gingival Fibroblasts
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Lee K, Ben Amara , Lee SC, Leesungbok R, Chung MA, Koo KT, Lee SW
- KMID: 2467059
- Tissue Eng Regen Med.
- 2019 Dec;16(6):675-684.
- doi: 10.1007/s13770-019-00227-6
BACKGROUND: Trichloroacetic acid (TCA) is an agent widely applied in dermatology for skin regeneration. To test whether TCA can offer an advantage for the regeneration of oral soft tissue defects,... -
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- Cell Division Cycle Associated 8 Is a Key Regulator of Tamoxifen Resistance in Breast Cancer
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Yu D, Shi L, Bu Y, Li W
- KMID: 2450118
- J Breast Cancer.
- 2019 Jun;22(2):237-247.
- doi: 10.4048/jbc.2019.22.e29
PURPOSE: Breast cancer (BC) is one of the most common malignancies globally, and millions of women worldwide are diagnosed with BC every year. Up to 70% of BC patients are... -
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- MicroRNA-186 targets SKP2 to induce p27(Kip1)-mediated pituitary tumor cell cycle deregulation and modulate cell proliferation
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He Z, Chen L, Wang Q, Yin C, Hu J, Hu X, Fei F, Tang J
- KMID: 2443605
- Korean J Physiol Pharmacol.
- 2019 May;23(3):171-179.
- doi: 10.4196/kjpp.2019.23.3.171
Pituitary tumors are usually benign but can occasionally exhibit hormonal and proliferative behaviors. Dysregulation of the G1/S restriction point largely contributes to the over-proliferation of pituitary tumor cells. F-box protein... -
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- Bleomycin Inhibits Proliferation via Schlafen-Mediated Cell Cycle Arrest in Mouse Alveolar Epithelial Cells
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Jang S, Ryu SM, Lee J, Lee H, Hong SH, Ha KS, Park WS, Han ET, Yang SR
- KMID: 2453983
- Tuberc Respir Dis.
- 2019 Apr;82(2):133-142.
- doi: 10.4046/trd.2017.0124
BACKGROUND: Idiopathic pulmonary fibrosis involves irreversible alveolar destruction. Although alveolar epithelial type II cells are key functional participants within the lung parenchyma, how epithelial cells are affected upon bleomycin (BLM)... -
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- Gomisin G Suppresses the Growth of Colon Cancer Cells by Attenuation of AKT Phosphorylation and Arrest of Cell Cycle Progression
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Maharjan S, Park BK, Lee SI, Lim Y, Lee K, Lee Y, Kwon HJ
- KMID: 2442013
- Biomol Ther.
- 2019 Feb;27(2):210-215.
- doi: 10.4062/biomolther.2018.054
Colorectal cancer is one of the leading causes of cancer related death due to a poor prognosis. In this study, we investigated the effect of Gomisin G on colon cancer... -
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- Apoptosis and Cell Cycle Arrest in Two Human Breast Cancer Cell Lines by Dieckol Isolated from Ecklonia cava
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You SH, Kim JS, Kim YS
- KMID: 2434903
- J Breast Dis.
- 2018 Dec;6(2):39-45.
- doi: 10.14449/jbd.2018.6.2.45
PURPOSE: Dieckol, a phlorotannin compound isolated from Ecklonia cava, has been reported to have antioxidant, antiviral, anti-inflammatory, and anticancer properties. The purpose of this study was to investigate its anticancer... -
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- Methanol Extracts of Codium fragile Induces Apoptosis through G1/S Cell Cycle Arrest in FaDu Human Hypopharynx Squamous Carcinoma Cells
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Lee SA, Park BR, Moon SM, Kim DK, Kim CS
- KMID: 2437356
- Int J Oral Biol.
- 2018 Jun;43(2):61-68.
- doi: 10.11620/IJOB.2018.43.2.061
Codium fragile (Suringar) Hariot is an edible green seaweed that belong to the Codiaceae family and has been used in Oriental medicine for the treatment of enterobiasis, dropsy, and dysuria.... -
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- Anti-proliferative Effect of 15,16-Dihydrotanshinone I Through Cell Cycle Arrest and the Regulation of AMP-activated Protein Kinase/Akt/mTOR and Mitogen-activated Protein Kinase Signaling Pathway in Human Hepatocellular Carcinoma Cells
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Hong JY, Park SH, Park HJ, Lee SK
- KMID: 2417368
- J Cancer Prev.
- 2018 Jun;23(2):63-69.
- doi: 10.15430/JCP.2018.23.2.63
BACKGROUND: 15,16-dihydrotanshinone I (DHTS) is a natural abietane diterpenoid that is mainly found in the roots of Salvia miltiorrhiza Bunge (Labiatae). DHTS exhibits a potential anti-proliferative effect in various human... -
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- Improvement of Cell Cycle Lifespan and Genetic Damage Susceptibility of Human Mesenchymal Stem Cells by Hypoxic Priming
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Lee CW, Kang D, Kim AK, Kim DY, Kim DI
- KMID: 2413501
- Int J Stem Cells.
- 2018 Jun;11(1):61-67.
- doi: 10.15283/ijsc17054
Hypoxic culture is widely recognized as a method to efficiently expand human mesenchymal stem cells (MSCs) without loss of stem cell properties. However, the molecular basis of how hypoxia priming... -
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- Panduratin A Inhibits Cell Proliferation by Inducing G0/G1 Phase Cell Cycle Arrest and Induces Apoptosis in Breast Cancer Cells
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Liu Q, Cao Y, Zhou P, Gui S, Wu X, Xia Y, Tu J
- KMID: 2421743
- Biomol Ther.
- 2018 May;26(3):328-334.
- doi: 10.4062/biomolther.2017.042
Because of the unsatisfactory treatment options for breast cancer (BC), there is a need to develop novel therapeutic approaches for this malignancy. One such strategy is chemotherapy using non-toxic dietary... -
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- Esculetin Inhibits the Survival of Human Prostate Cancer Cells by Inducing Apoptosis and Arresting the Cell Cycle
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Turkekul K, Colpan RD, Baykul T, Ozdemir MD, Erdogan S
- KMID: 2416947
- J Cancer Prev.
- 2018 Mar;23(1):10-17.
- doi: 10.15430/JCP.2018.23.1.10
BACKGROUND: Prostate cancer (PCa) is one of the most important causes of death in men and thus new therapeutic approaches are needed. In this study, antiproliferative and anti-migration properties of... -
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- 4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling
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Kim SC, Kang JI, Hyun JW, Kang JH, Koh YS, Kim YH, Kim KH, Ko JH, Yoo ES, Kang HK
- KMID: 2386909
- Biomol Ther.
- 2017 Jul;25(4):417-426.
- doi: 10.4062/biomolther.2016.003
4-O-methylhonokiol, a neolignan compound from Magnolia Officinalis, has been reported to have various biological activities including hair growth promoting effect. However, although transforming growth factor-β (TGF-β) signal pathway has an... -
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- Valproic Acid Modulates the Multipotency in Periodontal Ligament Stem Cells via p53-Mediated Cell Cycle
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Um S, Lee H, Zhang Q, Kim HY, Lee JH, Seo BM
- KMID: 2377345
- Tissue Eng Regen Med.
- 2017 Apr;14(2):153-162.
- doi: 10.1007/s13770-017-0027-4
Human periodontal ligament stem cells (PDLSCs), a type of mesenchymal stem cell, are a promising source for dental regeneration and are identified in human periodontal ligaments from extracted third molars.... -
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- Quercetin induces apoptosis and cell cycle arrest in triple-negative breast cancer cells through modulation of Foxo3a activity
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Nguyen LT, Lee YH, Sharma AR, Park JB, Jagga S, Sharma G, Lee SS, Nam JS
- KMID: 2371039
- Korean J Physiol Pharmacol.
- 2017 Mar;21(2):205-213.
- doi: 10.4196/kjpp.2017.21.2.205
Quercetin, a plant-derived flavonoid found in fruits, vegetables and tea, has been known to possess bioactive properties such as anti-oxidant, anti-inflammatory and anti-cancer. In this study, anti-cancer effect of quercetin... -
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- Sorbus rufopilosa Extract Exhibits Antioxidant and Anticancer Activities by Inducing Cell Cycle Arrest and Apoptosis in Human Colon Adenocarcinoma HT29 Cells
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Oh YN, Jin S, Park HJ, Kwon HJ, Kim BW
- KMID: 2367562
- J Cancer Prev.
- 2016 Dec;21(4):249-256.
- doi: 10.15430/JCP.2016.21.4.249
BACKGROUND: Sorbus rufopilosa, a tsema rowan, is a species of the small ornamental trees in the genus Sorbus and the family Rosaceae found in East Asia. The bioactivities of S.... -
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- Effects of Triterpenoids from Luvunga scandens on Cytotoxic, Cell Cycle Arrest and Gene Expressions in MCF-7 Cells
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Taher M, Al-Zikri P, Susanti D, Ichwan SJ, Rezali MF
- KMID: 2366699
- Nat Prod Sci.
- 2016 Dec;22(4):293-298.
- doi: 10.20307/nps.2016.22.4.293
Plant-derived triterpenoids commonly possesses biological properties such as anti-inflammatory, anti-microbial, anti-viral and anti-cancer. Luvunga scandens is one of the plant that produced triterpenoids. The aims of the study was to... -
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- Exosomes Secreted by Toxoplasma gondii-Infected L6 Cells: Their Effects on Host Cell Proliferation and Cell Cycle Changes
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Kim MJ, Jung BK, Cho J, Song H, Pyo KH, Lee JM, Kim MK, Chai JY
- KMID: 2164011
- Korean J Parasitol.
- 2016 Apr;54(2):147-154.
- doi: 10.3347/kjp.2016.54.2.147
Toxoplasma gondii infection induces alteration of the host cell cycle and cell proliferation. These changes are not only seen in directly invaded host cells but also in neighboring cells. We... -
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- CRM1 inhibitor S109 suppresses cell proliferation and induces cell cycle arrest in renal cancer cells
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Liu X, Chong Y, Liu H, Han Y, Niu M
- KMID: 2388672
- Korean J Physiol Pharmacol.
- 2016 Mar;20(2):161-168.
- doi: 10.4196/kjpp.2016.20.2.161
Abnormal localization of tumor suppressor proteins is a common feature of renal cancer. Nuclear export of these tumor suppressor proteins is mediated by chromosome region maintenance-1 (CRM1). Here, we investigated... -
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- Overexpression of Cell Cycle Proteins of Peripheral Lymphocytes in Patients with Alzheimer's Disease
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Kim H, Kwon YA, Ahn IS, Kim S, Kim S, Jo SA, Kim DK
- KMID: 2316605
- Psychiatry Investig.
- 2016 Jan;13(1):127-134.
- doi: 10.4306/pi.2016.13.1.127
OBJECTIVE: Biological markers for Alzheimer's disease (AD) will help clinicians make objective diagnoses early during the course of dementia. Previous studies have suggested that cell cycle dysregulation begins earlier than... -
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- Viriditoxin Induces G2/M Cell Cycle Arrest and Apoptosis in A549 Human Lung Cancer Cells
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Park JH, Noh TH, Wang H, Kim ND, Jung JH
- KMID: 2312911
- Nat Prod Sci.
- 2015 Dec;21(4):282-288.
- doi: 10.20307/nps.2015.21.4.282
Viriditoxin is a fungal metabolite isolated from Paecilomyces variotii, which was derived from the giant jellyfish Nemopilema nomurai. Viriditoxin was reported to inhibit polymerization of FtsZ, which is a key... -
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