- Expression of Cyclin A, B1, D1, D3, and E in Non-Small Lung Cancers
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Ha SY, Kim HK, Im JS, Cho HY, Chung DH, An J
- KMID: 2199874
- J Lung Cancer.
- 2012 Jun;11(1):33-37.
- doi: 10.6058/jlc.2012.11.1.33
PURPOSE: Cyclins, and their associated cyclin dependent kinases, regulate progression of the cell cycle through the G1 phase and into the S-phase during the DNA replication process. Cyclin E regulation... -
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- Reduced Expression of Cyclins and Proliferative Indices on the Psoriatic Epidermis after 12 Weeks of Oral Cyclosporin Therapy
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Han SS, Hyun OS, Chang SE, Lee MW, Choi JH, Moon KC, Koh JK
- KMID: 1881992
- Ann Dermatol.
- 2006 Oct;18(2):51-58.
- doi: 10.5021/ad.2006.18.2.51
Cell growth characterized by cell cycle progression is regulated by cyclin-dependent kinase (CDK). CDKs are activated by binding cyclins such as cyclin A, cyclin B, cyclin D1, and cyclin E.... -
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- Cyclin E expression in benign and malignant epithelial neoplasms of the gallbladder
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Jin YM, Yim H, Shim C
- KMID: 699965
- Yonsei Med J.
- 1997 Oct;38(5):301-306.
- doi: 10.3349/ymj.1997.38.5.301
Cyclins are the regulatory subunits of cyclin-dependent kinase and play an important role in cell proliferation. Many tumors, such as colon, breast and gastric carcinomas are known to be involved... -
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- Expression of cyclin D1 and cyclin E in human gastric carcinoma and its clinicopathologic significance
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Ahn MJ, Kim BH, Jang SJ, Hong EK, Lee WM, Baik HK, Park HK, Lee CB, Ki M
- KMID: 645211
- J Korean Med Sci.
- 1998 Oct;13(5):513-518.
- doi: 10.3346/jkms.1998.13.5.513
Cyclin D1 and cyclin E are the mammalian G1 cydins that are both required and rate limiting for entry into S phase. Alterations in cell cycle regulators and subsequent... -
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- Association Between Infection of Human Papillomavirus and Decreased Expression of Cyclin DI in Cervical Neoplasia
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Kim SJ, Roh MS
- KMID: 1928717
- Korean J Gynecol Oncol Colposc.
- 1999 Dec;10(4):315-323.
Cyclin Dl, one of Gl cyclin gene subfamily, and human papillomaviruses (HPV) oncoprotein E7 have a homology in binding sites for the retinoblastoma tumor-suppressor protein. In order to evaluate the... -
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- Expression of pRb, p16, Cyclin D1 and Cyclin E in Infiltrating Duct Carcinoma of the Breast
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Hur HK, Roh MS, Jeong JS, Rha SH, Huh GY, Hong SH
- KMID: 1725835
- Korean J Pathol.
- 2001 Oct;35(5):416-423.
BACKGROUND: Inactivation of the retinoblastoma protein (pRb) is a mechanism by which tumor cells can subdue normal growth control. Among the molecules involved in control of pRb phosphorylation, cyclin D1... -
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- Interrelation of Cyclin D1, Cyclin E, and p27Kip1 Expression on Tissue Arrays of Breast Cancer
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Han SH, Park KM, Bae BN, Ryu SY, Kim KH, Kim HJ, Kim YD, Kim HY
- KMID: 1972945
- Cancer Res Treat.
- 2002 Oct;34(5):388-393.
PURPOSE: To evaluate the clinical impact of the altered expression of cell cycle regulators in stage I and II breast cancers. MATERIALS AND METHODS: The interaction between cyclin D1/E and p27Kip1... -
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- Effects of DCA on Cell Cycle Proteins in Colonocytes
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Ha YH, Park DG
- KMID: 2198785
- J Korean Soc Coloproctol.
- 2010 Aug;26(4):254-259.
- doi: 10.3393/jksc.2010.26.4.254
PURPOSE: Evidence that indicates bile acid is a promoter of colon cancer exists. Deoxycholic acid (DCA) modifies apoptosis or proliferation by affecting intracellular signaling and gene expression. However, because previous... -
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- Expression of the Low Molecular Weight Cyclin E is Early Event in Colorectal Carcinogenesis
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Jung YH, Choi SH, Park DG
- KMID: 2166159
- Cancer Res Treat.
- 2003 Oct;35(5):419-424.
PURPOSE: Cyclin E is essential for the transition from the G1 to S-phase of the cell cycle, and plays important roles in carcinogenesis in many cancers. Especially, low molecular weight... -
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- Effect of Deoxycholic Acid on the Proliferation and Apoptosis of HCT116 Colon Cancer Cells
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Park DG
- KMID: 2004406
- J Korean Surg Soc.
- 2005 Mar;68(3):211-217.
PURPOSE: Bile acids were considered as a promoting factor for colon cancers. It has been suggested that bile acids could promote cellular proliferation or apoptosis according to their concentration. Therefore,... -
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- Correlation between G1 Cyclins Expression and Clinical Prognostic Parameters in Endometrial Carcinoma
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Kim YT, Kim SH, Kim JW, Lee JW, Park KH
- KMID: 1615588
- Korean J Gynecol Oncol Colposc.
- 2003 Mar;14(1):30-39.
OBJECTIVE: Cyclins D1 and E play important roles in the progression of cell through G1 phase of the cell cycle. Amplification and/or overexpression of the cyclin D1 gene and aberrant... -
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- Relation between the Low Molecular Weight Cyclin E and Mutator Phenotype in Sporadic Colorectal Cancer
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Park DG
- KMID: 1940535
- J Korean Surg Soc.
- 2005 Sep;69(3):224-230.
PURPOSE: Cyclin E/CDK2 complexes are thought to play critical roles in multiple cell cycle events, including DNA replication, centrosome duplication, and activation of the E2F transcriptional program. Deregulation of the... -
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- Prognostic Significance of Cyclin E and p27 in Stage I Non-Small Cell Lung Cancer
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Jo BG, Cho SR, Chun BK
- KMID: 2062657
- Korean J Thorac Cardiovasc Surg.
- 2003 Jan;36(1):7-14.
BACKGROUND: Cyclin E plays a pivotal role in the regulation of G1-S transition and could consequently be a deregulated molecule in tumors. The activity of the cdk2-cyclin E complex is... -
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- Overexpression of cyclin D1 and cyclin E in 1,2-dimethylhydrazine dihydrochloride-induced rat colon carcinogenesis
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Hur K, Kim JR, Yoon BI, Lee JK, Choi JH, Oh GT, Kim DY
- KMID: 1094650
- J Vet Sci.
- 2000 Dec;1(2):121-126.
Deregulation of G1 cyclins has been reported in several human and rodent tumors including colon cancer. To investigate the expression pattern of G1 cyclins in 1,2- dimethyl-hydrazine dihydrochloride (DMH)-induced rat... -
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- Significance of Cyclin E, p53, E-cadherin, and beta-Catenin Expressions in Gastric Adenocarcinomas
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Xuan LP, Lee MJ, Suh CH
- KMID: 2275469
- Korean J Pathol.
- 2004 Aug;38(4):213-220.
BACKGROUND: Gastric cancer is reported to be one of the leading causes of mortality in Korea. Our aim was to evaluate the clinicopathologic usefulness of cyclin E, p53, E-cadherin and... -
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- Augmentation of Butyrate-induced Differentiation of Human Hepatocyte for the Development of an Efficient Bioartificial Liver
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Kim YJ, Lee HS
- KMID: 2084972
- Korean J Gastroenterol.
- 2001 Jan;37(1):35-42.
BACKGROUND/AIMS: We examined whether we could produce hepatocytes with further differentiated functions by promoting G1-S transition of the cell cycle in a butyrate-treated human hepatocyte cell line that we have... -
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- The clinicopathological relevance for the expression of cyclin E, CDK2, and p27 in endometrial carcinoma
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Baek YJ, Chong HI, Jang HJ, Suh DS, Yoon MS, Choi KU
- KMID: 2273500
- Korean J Obstet Gynecol.
- 2008 Oct;51(10):1112-1120.
OBJECTIVE: The aim of this study was to evaluate the clinicopathological relevance for the expression of cyclin E, CDK2 and p27 in endometrial carcinoma. METHODS: With a retrospective review, slide samples... -
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- Expression of cyclin E in gestational trophoblastic disease
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Yi JW, Kim YT, Kim JW, Kim SH, Kim DK
- KMID: 2143479
- Korean J Gynecol Oncol Colposc.
- 2002 Mar;13(1):38-48.
Gestational trophoblastic disease represents a spectrum of lesions characterized by an abnormal proliferation of trophoblast, including partial mole, complete mole, invasive mole, choriocarcinoma, and placental site trophoblastic tumor, which have... -
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- The Correlations between the Expression of Cyclin E and Clinical Features of the Primary Breast Cancer
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Park JW, Yang KH, Bae BN, Kim KH, Kim HJ, Kim YD, Kim HY, Park KM, Han SH
- KMID: 2324990
- J Korean Surg Soc.
- 2002 Nov;63(5):372-377.
PURPOSE: Cyclin E is a key regulatory protein in the G1-S transition during the cell cycle. The correlations between cyclin E protein and the clinical features of breast cancer... -
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- Aberrant Cell Cycle Regulation in Cervical Carcinoma
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Kim YT, Zhao M
- KMID: 2158138
- Yonsei Med J.
- 2005 Oct;46(5):597-613.
- doi: 10.3349/ymj.2005.46.5.597
Carcinoma of the uterine cervix is one of the most common malignancies among women worldwide. Human papillomaviruses (HPV) have been identified as the major etiological factor in cervical carcinogenesis. However,... -
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