Korean J Gynecol Oncol Colposc.  2003 Mar;14(1):30-39.

Correlation between G1 Cyclins Expression and Clinical Prognostic Parameters in Endometrial Carcinoma

• Kim YT
• Kim SH
• Kim JW
• Lee JW
• Park KH

Abstract

OBJECTIVE
Cyclins D1 and E play important roles in the progression of cell through G1 phase of the cell cycle. Amplification and/or overexpression of the cyclin D1 gene and aberrant expression of cyclin E has been described in various forms of human cancer. However, the role of cyclins D1 and E in endometrial cancer has been poorly defined.
METHODS
We examined the expression of cyclins D1 and E by Northern blot technique in 33 endometrial carcinoma specimens and 9 control endometrial tissues. In addition, expression of the estrogen and progesterone receptors (ER, PR) was studied by enzyme immunoassay to explore the relationship between cyclins D1 and E and endometrial cancer.
RESULTS
We found that cyclin D1 expression showed down-regulated expression in endometrial cancer. Underexpression of cyclin D1 inversely related with ER positivity. However, cyclin E expression was increased in ER positive cancer group. Other clinicopathological prognostic factors were not correlated with cyclins D1 and E expression.
CONCLUSION
Further study based on larger numbers of cases with correlation of cyclins D1 and E status and survival data will be needed to elucidate the use of cyclin expressions as prognostic factor.

Keyword

Cyclins D1 and E; Endometrial carcinoma

MeSH Terms

Blotting, Northern
Cell Cycle
Cyclin D1
Cyclin E
Cyclins*
Endometrial Neoplasms*
Estrogens
Female
G1 Phase
Genes, bcl-1
Humans
Immunoenzyme Techniques
Receptors, Progesterone
Cyclin D1
Cyclin E
Cyclins
Estrogens
Receptors, Progesterone