Korean J Obstet Gynecol.  2008 Oct;51(10):1112-1120.

The clinicopathological relevance for the expression of cyclin E, CDK2, and p27 in endometrial carcinoma

Affiliations
  • 1Department of Obstetrics & Gynecology, School of Medicine, Pusan National University Hospital, Busan, Korea. msyoon@pusan.ac.kr
  • 2Department of Pathology, School of Medicine, Pusan National University Hospital, Busan, Korea.

Abstract


OBJECTIVE
The aim of this study was to evaluate the clinicopathological relevance for the expression of cyclin E, CDK2 and p27 in endometrial carcinoma.
METHODS
With a retrospective review, slide samples (n=71) were analyzed. All patients had been treated with hysterectomy from January 1998 to December 2006. The expression of cyclin E, CDK2 and p27 were analyzed using immunohistochemical staining.
RESULTS
Of 71 cases, the positive expression was cyclin E; 28 cases (39.4%), CDK2; 29 cases (40.8%). The expression of cyclin E showed positive correlation with lymph node metastasis (P=0.033) and estrogen receptor. The expression of CDK2 showed positive correlation with estrogen receptor (P=0.000). The negative expression of p27 was 42 cases (59.2%) and showed no correlation with other clinicopathological factors. Cyclin E overexpression with loss of p27 expression showed positive correlation with advanced stage (P=0.002), lymphovascular invasion (P=0.030) and lymph node metastasis (P=0.002).
CONCLUSION
Cyclin E overexpression with loss of p27 expression could be an useful negative prognostic factors for endometrial carcinoma.

Keyword

Cyclin E; CDK; p27; Endometrial carcinoma
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