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Protein Expression of Cyclin B1, Transferrin Receptor, and Fibronectin Is Correlated with the Prognosis of Adrenal Cortical Carcinoma

Moon SJ, Kim JH, Kong SH, Shin CS

BACKGROUND: Adrenal cortical carcinoma (ACC) is a rare cancer with a variable prognosis. Several prognostic factors of ACC have been previously reported, but a proteomic analysis has not yet been...
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β-carotene Inhibits Expression of c-Myc and Cyclin E in Helicobacter pylori-infected Gastric Epithelial Cells

Kim D, Lim JW, Kim H

BACKGROUND: Helicobacter pylori infection is a major risk factor in the development of gastric cancer. H. pylori infection of gastric epithelial cells increases the levels of reactive oxygen species (ROS),...
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Role of E-cadherin and cyclin D1 as predictive markers of aggression and clonal expansion in head and neck squamous cell carcinoma

Shergill K, Sen A, Pillai HJ

OBJECTIVES: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Inconsistency in various histopathologic features for predicting nodal metastasis and overall prognosis and a better...
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Gomisin G Inhibits the Growth of Triple-Negative Breast Cancer Cells by Suppressing AKT Phosphorylation and Decreasing Cyclin D1

Maharjan S, Park BK, Lee SI, Lim Y, Lee K, Kwon HJ

A type of breast cancer with a defect in three molecular markers such as the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor is called triple-negative breast cancer...
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Basaloid Squamous Cell Carcinoma of the Head and Neck: Subclassification into Basal, Ductal, and Mixed Subtypes Based on Comparison of Clinico-pathologic Features and Expression of p53, Cyclin D1, Epidermal Growth Factor Receptor, p16, and Human Papillomavirus

Cho KJ, Jeong SU, Kim SB, Lee SW, Choi SH, Nam SY, Kim SY

BACKGROUND: Basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma with distinct pathologic characteristics. The histogenesis of BSCC is not fully understood, and the cancer has...
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Immunohistochemical evaluation of p63 and cyclin D1 in oral squamous cell carcinoma and leukoplakia

Patel SB, Manjunatha BS, Shah V, Soni N, Sutariya R

OBJECTIVES: There are only a limited number of studies on cyclin D1 and p63 expression in oral squamous cell carcinoma (OSCC) and leukoplakia. This study compared cyclin D1 and p63...
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Glycogen synthase kinase 3β and cyclin D1 expression in cervical carcinogenesis

Park H, Lee M, Kim DW, Hong SY, Lee H

OBJECTIVE: Glycogen synthase kinase 3β (GSK3β) is a pluripotent protein kinase involved in the development of cancers through regulation of numerous oncogenic molecules. Cyclin D1, an important regulator of G1...
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Longer Survival in Patients with Breast Cancer with Cyclin D1 Over-Expression after Tumor Recurrence: Longer, but Occupied with Disease

Chung J, Noh H, Park KH, Choi E, Han A

  • KMID: 2353083
  • J Breast Cancer.
  • 2014 Mar;17(1):47-53.
PURPOSE: The effect of cyclin D1 overexpression on breast cancer outcomes and prognosis is controversial, even though amplification of the cyclin D1 gene, CCND1, has been shown to be associated...
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Expression of Cyclin D1, Cytokeratin 7, Cytokeratin 20 and Vimentin in Papillary Thyroid Cancer and Relationship with Patient's Prognostic Factors

Kim HJ, Kim YS, Kim SW, Kim KC

PURPOSE: Cyclin D1, cytokeratin(CK)7, CK20 and vimentin play an important role in tumorigenesis and tumor progression. Our aim was to investigate the expression of cyclin D1, CK7, CK20 and vimentin...
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Prognostic Significance COX-2, VEGF and Cyclin D1 in Distant Metastasis of Breast Cancer

Lee JS, Choi JH

PURPOSE: The most important independent prognostic factors of breast cancer have been reported to the tumor size and lymph node metastasis, as well as DNA ploidy, proliferation index, and various...
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Expression of Mutant p53 Protein, p21(waf1/cip1) and Cyclin D1 in Dysplasia and Adenocarcinoma of Stomach

Yun KJ, Kim HS, Jo HJ, Choi SC

  • KMID: 2304817
  • Korean J Gastrointest Endosc.
  • 2007 Jan;34(1):9-13.
BACKGROUND/AIMS: Gastric carcinoma is a major cause of morbidity and mortality in Korea. It evolves through dysplasia to an invasive adenocarcinoma. The carcinogenesis of dysplasia and adenocarcinoma in the stomach...
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Expression of Cyclin D1, Vimentin and Thyroglobulin in Papillary Thyroid Cancer and Its Correlation with Clinicobiological Factors

Park SJ, Na EJ, Kim SY, Bae HY, Kim DH, Lim SC, Kim KC

  • KMID: 2096336
  • J Korean Surg Soc.
  • 2006 Jun;70(6):425-429.
PURPOSE: An increased expression of cyclin D1 has been observed in several tumors. Vimentin is known to be present in undifferentiated thyroid cancer. The serum thyroglobulin level can be a...
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Detection of Cyclin D1 Protein in Inflammation, Dysplasia and Carcinoma of the Laryngeal Mucosa

Bai CH, Choi YH, Chen SM, Kim YD, Shim YR, Song SY

  • KMID: 2276624
  • Korean J Otolaryngol-Head Neck Surg.
  • 2006 Apr;49(4):415-419.
BACKGROUND AND OBJECTIVES: Cyclin D1 is one of the proteins regulating G1-S transition in the cell cycle and is considered to play an important role in subsequent mitotic division. So...
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Expressions of Cyclin E-pathway Proteins (cyclinE, cdk2, p21, p27, p57) and Their Prognostic Significance in Non-small Cell Lung Carcinomas

Jung JH, Park G, Lee MA, Byun JH, Jung CK, Lee H, Lee KY, Shim SI, Kang CS

  • KMID: 1593157
  • Korean J Pathol.
  • 2006 Feb;40(1):24-31.
BACKGROUND: The aberrant expression of cyclins, cdk and cdk inhibitor has been shown to be involved in oncogenic transformation. The aim of this study was to investigate the expression of...
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Reduced Expression of Cyclins and Proliferative Indices on the Psoriatic Epidermis after 12 Weeks of Oral Cyclosporin Therapy

Han SS, Hyun OS, Chang SE, Lee MW, Choi JH, Moon KC, Koh JK

Cell growth characterized by cell cycle progression is regulated by cyclin-dependent kinase (CDK). CDKs are activated by binding cyclins such as cyclin A, cyclin B, cyclin D1, and cyclin E....
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Relation between the Low Molecular Weight Cyclin E and Mutator Phenotype in Sporadic Colorectal Cancer

Park DG

  • KMID: 1940535
  • J Korean Surg Soc.
  • 2005 Sep;69(3):224-230.
PURPOSE: Cyclin E/CDK2 complexes are thought to play critical roles in multiple cell cycle events, including DNA replication, centrosome duplication, and activation of the E2F transcriptional program. Deregulation of the...
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Cyclin B1 and D1 expression in invasive cervical cancer

Kim YT, Zhao M, Kim HY, Kang MH, Kim JW, Kim SH, Kim JH, Kim SW, Yoon BS

  • KMID: 1575056
  • Korean J Gynecol Oncol.
  • 2005 Sep;16(3):256-263.
OBJECTIVE: Cyclin is a family of regulatory proteins that play a key role in controlling the cell cycle. Abnormalities of cell cycle regulators, including cyclins and cyclin dependent kinases (CDKs),...
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The Role of cAMP/PKA Activation on Exendin-4-Induced Cyclin D1 Expression in INS-1 Cell

Ryu GR, Kang JH, Jang HI, Ko SH, Jeong IK, Rhie DJ, Yoon SH, Hahn SJ, Jo YH, Kim MS, Kim MJ

  • KMID: 2177757
  • J Korean Diabetes Assoc.
  • 2005 Jul;29(4):295-303.
BACKGROUND: Glucagon-like peptide-1(GLP-1) and exendin-4(EX-4) have been known to induce pancreatic islet proliferation and increases in the betacell mass. Cyclin D1 is a key protein responsible for the entry of...
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Cyclin G2 Expression in Gastric-cancer Tissues

Choi MG, Hong SK, Park SB, Paik YH, Noh JH, Sohn TS, Kim SJ, Kim S

  • KMID: 2372793
  • J Korean Gastric Cancer Assoc.
  • 2005 Dec;5(4):273-280.
PURPOSE: Cyclin G2 has been reported to be a negative cell-cycle regulator in various cancer tissues. However, the pattern of cyclin G2 expression in gastric cancer is relatively unknown. We...
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A Study of Influences of p53 Mutation, Cyclin D1 Over Expression, Ki67 Index, Mitotic Index on the Prognosis of Esophageal Squamous Cell Carcinoma

Lee HW, Cho SK, Sung SW, Lee HJ, Kim YT, Kang MC, Kim JH

  • KMID: 2289060
  • Korean J Thorac Cardiovasc Surg.
  • 2005 Dec;38(12):835-843.
BACKGROUND: Cancer of the esophagus is one of the most malignant tumors with poor prognosis. The p53 gene alteration, over expression of Cyclin D1, and Ki67 index were thought to...
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