J Korean Med Sci.  1998 Oct;13(5):513-518. 10.3346/jkms.1998.13.5.513.

Expression of cyclin D1 and cyclin E in human gastric carcinoma and its clinicopathologic significance

• Ahn MJ
• Kim BH
• Jang SJ
• Hong EK
• Lee WM
• Baik HK
• Park HK
• Lee CB
• Ki M

• KMID: 645211
• DOI: http://doi.org/10.3346/jkms.1998.13.5.513

Abstract

Cyclin D1 and cyclin E are the mammalian G1 cydins that are both required and rate limiting for entry into S phase. Alterations in cell cycle regulators and subsequent deregulation of the cell cycle are frequently involved in tumorigenesis and/or tumor progression. We investigated the expression of cyclin D1 and cyclin E protein in 84 gastric carcinoma by immunohistochemical staining and also the relevance of each cyclin expression to the clinical outcomes. Overexpression of cyclin D1 and cyclin E was noted in 21 of 84 (25.0%) and 34 of 84 (40.5%) gastric cancer tissues, respectively. There was a significant correlation between overexpression of cyclin E and lymph node metastasis (p=0.003), recurrence (p=0.043), disease free survival (p=0.0378) and overall survival (p=0.0319), but no correlation was noted between overexpression of cyclin D1 and other clinicopathologic variables. These findings suggest that overexpression of cyclin E and cyclin D1 is a frequent finding in gastric cancer and immunohistochemical analysis for cell cycle regulators, especially cyclin E might be a useful prognostic indicator in gastric cancer.

MeSH Terms

Adult
Cyclin D1/biosynthesis*
Cyclin E/biosynthesis*
Female
Human
Male
Stomach Neoplasms/pathology
Stomach Neoplasms/metabolism*