Korean J Pathol.  2009 Feb;43(1):13-19. 10.4132/KoreanJPathol.2009.43.1.13.

The Expression of Hypoxia Inducible Factor-1alpha and Its Correlation with the Expressions of Cyclin A1 and Cyclin B1 and the Clinicopathologic Factors of Uterine Cervical Carcinoma

• Pyo JY
• Cho JH
• Kim H
• Park JP
• Kim YT
• Cho NH

• KMID: 1472549
• DOI: http://doi.org/10.4132/KoreanJPathol.2009.43.1.13

Abstract

BACKGROUND: Hypoxia inducible factor-1alpha(HIF-1alpha) is a transcription factor for various target genes that are involved in adapting cells to hypoxia. It promotes cell proliferation and survival via modulation of such cell cycle regulators such as cyclin A1 and cyclin B1 in response to hypoxia. This is associated with local failure of radiotherapy, which renders a poor prognosis for cervical carcinoma.
METHODS
Using the tissue histologic sections and a tissue microarray of the archived biopsy and surgical specimens of uterine cervical carcinoma from 57 patients who were treated with radiation therapy alone, we performed immunohistochemical staining for HIF-1alpha and cyclin A1 and B1 to evaluate the correlations between the expressions of these proteins in tumors and the clinicopathologic parameters associated with the prognosis.
RESULTS
The large tumor cell nests and invasive front margins of the tumors showed comparatively intense immunoreactivity of HIF-1alpha. There was no significant correlation between the HIF-1alpha, cyclin A1 and cyclin B1 expressions and the clinicopathologic factors.
CONCLUSIONS
The HIF-1alpha expression showed marked intra-tumoral heterogeneity. The HIF-1alpha expression is neither a powerful predictor of resistance to radiotherapy nor is it a poor prognostic marker in cervical carcinoma patients who are treated with radiotherapy. The expressions of cyclin A1 and cyclin B1 are neither independently associated with the response of radiation therapy nor are they associated with the prognostic parameters of uterine cervical carcinoma.

Keyword

Cervix cancer; Radiotherapy; Hypoxia inducible factor 1, alpha subunit; Cyclin A; Cyclin B

MeSH Terms

Anoxia
Biopsy
Cell Cycle
Cell Proliferation
Cyclin A
Cyclin A1
Cyclin B
Cyclin B1
Cyclins
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
Population Characteristics
Prognosis
Proteins
Transcription Factors
Uterine Cervical Neoplasms
Cyclin A
Cyclin A1
Cyclin B
Cyclin B1
Cyclins
Hypoxia-Inducible Factor 1, alpha Subunit
Proteins
Transcription Factors