- Hypoxia-inducible factor 1, hepatocellular carcinoma and angiogenesis
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Kim JW
- KMID: 1717321
- Korean J Hepatol.
- 2010 Sep;16(3):278-279.
- doi: 10.3350/kjhep.2010.16.3.278
No abstract available. -
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- Development of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer Therapy
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Yu T, Tang B, Sun X
- KMID: 2419104
- Yonsei Med J.
- 2017 May;58(3):489-496.
- doi: 10.3349/ymj.2017.58.3.489
Hypoxia is frequently observed in solid tumors and also one of the major obstacles for effective cancer therapies. Cancer cells take advantage of their ability to adapt hypoxia to initiate... -
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- HIF-1alpha Upregulation due to Depletion of the Free Ubiquitin Pool
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Kim J, So D, Shin HW, Chun YS, Park JW
- KMID: 2344170
- J Korean Med Sci.
- 2015 Oct;30(10):1388-1395.
- doi: 10.3346/jkms.2015.30.10.1388
Hypoxia-inducible factor 1alpha (HIF-1alpha), which transactivates a variety of hypoxia-induced genes, is rapidly degraded under nomoxia through the hydroxylation-ubiquitination-proteasome pathway. In this study, we addressed how HIF-1alpha is stabilized by... -
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- The Expression of Hypoxia Inducible Factor-1alpha and Its Correlation with the Expressions of Cyclin A1 and Cyclin B1 and the Clinicopathologic Factors of Uterine Cervical Carcinoma
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Pyo JY, Cho JH, Kim H, Park JP, Kim YT, Cho NH
- KMID: 1472549
- Korean J Pathol.
- 2009 Feb;43(1):13-19.
- doi: 10.4132/KoreanJPathol.2009.43.1.13
BACKGROUND: Hypoxia inducible factor-1alpha(HIF-1alpha) is a transcription factor for various target genes that are involved in adapting cells to hypoxia. It promotes cell proliferation and survival via modulation of such... -
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- Constitutive stabilization of hypoxia-inducible factor alpha selectively promotes the self-renewal of mesenchymal progenitors and maintains mesenchymal stromal cells in an undifferentiated state
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Park IH, Kim KH, Choi HK, Shim JS, Whang SY, June Hahn , Kwon OJ, Oh IH
- KMID: 2154263
- Exp Mol Med.
- 2013 Sep;45(9):e44.
With the increasing use of culture-expanded mesenchymal stromal cells (MSCs) for cell therapies, factors that regulate the cellular characteristics of MSCs have been of major interest. Oxygen concentration has been... -
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- Deferoxamine Improves Alveolar and Pulmonary Vascular Development by Upregulating Hypoxia-inducible Factor-1alpha in a Rat Model of Bronchopulmonary Dysplasia
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Choi CW, Lee J, Lee HJ, Park HS, Chun YS, Kim BI
- KMID: 2344155
- J Korean Med Sci.
- 2015 Sep;30(9):1295-1301.
- doi: 10.3346/jkms.2015.30.9.1295
Fetal lung development normally occurs in a hypoxic environment. Hypoxia-inducible factor (HIF)-1alpha is robustly induced under hypoxia and transactivates many genes that are essential for fetal development. Most preterm infants... -
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- Survival of hypoxic human mesenchymal stem cells is enhanced by a positive feedback loop involving miR-210 and hypoxia-inducible factor 1
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Chang W, Lee CY, Park JH, Park MS, Maeng LS, Yoon CS, Lee MY, Hwang KC, Chung YA
- KMID: 1482815
- J Vet Sci.
- 2013 Mar;14(1):69-76.
- doi: 10.4142/jvs.2013.14.1.69
The use of mesenchymal stem cells (MSCs) has emerged as a potential new treatment for myocardial infarction. However, the poor viability of MSCs after transplantation critically limits the efficacy of... -
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- Blockade of VEGFR-1 and VEGFR-2 Enhances Paclitaxel Sensitivity in Gastric Cancer Cells
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Hwang JE, Lee JH, Park MR, Kim DE, Bae WK, Shim HJ, Cho SH, Chung IJ
- KMID: 1503899
- Yonsei Med J.
- 2013 Mar;54(2):374-380.
- doi: 10.3349/ymj.2013.54.2.374
PURPOSE: Hypoxia-inducible factor-1alpha (HIF-1alpha) increases transcription of the vascular endothelial growth factor (VEGF) gene. Inhibition of VEGF abolishes VEGF mediated induction of HIF-1alpha. Recent reports suggested that HIF-1alpha also mediated... -
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- Phospholipase D activates HIF-1-VEGF pathway via phosphatidic acid
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Han S, Huh J, Kim W, Jeong S, Min DS, Jung Y
- KMID: 2155391
- Exp Mol Med.
- 2014 Dec;46(12):e126.
- doi: 10.1038/emm.2014.86
Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival. Therefore, PLD is... -
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- Phospholipase D2 promotes degradation of hypoxia-inducible factor-1alpha independent of lipase activity
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Park MH, Bae SS, Choi KY, Min DS
- KMID: 2359883
- Exp Mol Med.
- 2015 Nov;47(11):e196.
- doi: 10.1038/emm.2015.87
Hypoxia-inducible factor-1alpha (HIF-1alpha) is a key transcriptional mediator that coordinates the expression of various genes involved in tumorigenesis in response to changes in oxygen tension. The stability of HIF-1alpha protein... -
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- The Effect of HIF-1alpha siRNA on Growth and Chemosensitivity of Mia-paca Cell Line
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Yang L, Kang WK
- KMID: 1084504
- Yonsei Med J.
- 2008 Apr;49(2):295-300.
- doi: 10.3349/ymj.2008.49.2.295
PURPOSE: Hypoxia-inducible factor-1alpha (HIF-1alpha) primarily mediates the hypoxic response. HIF-1alpha induction by various stimuli contributes to cell proliferation and survival. To investigate the effect of HIF-1alpha, we used small interfering... -
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- Effects of echinomycin on endothelin-2 expression and ovulation in immature rats primed with gonadotropins
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Wang Z, Zhang Z, Wu Y, Chen L, Luo Q, Zhang J, Chen J, Luo Z, Huang X, Cheng Y
- KMID: 1506225
- Exp Mol Med.
- 2012 Oct;44(10):615-621.
Echinomycin is a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity, which plays a crucial role in ovarian ovulation in mammalians. The present study was designed to test the hypothesis that... -
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- Nur77 upregulates HIF-alpha by inhibiting pVHL-mediated degradation
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Kim BY, Kim H, Cho EJ, Youn HD
- KMID: 1103590
- Exp Mol Med.
- 2008 Feb;40(1):71-83.
- doi: 10.3858/emm.2008.40.1.71
In this study, we investigated the role of Nur77, an orphan nuclear receptor, in HIF-alpha transcriptional activity. We found that Nur77 associates and stabilizes HIF-1alpha via indirect interaction. Nur77 was... -
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- Effects of Omega-3 Fatty Acids on Erectile Dysfunction in a Rat Model of Atherosclerosis-induced Chronic Pelvic Ischemia
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Shim JS, Kim DH, Bae JH, Moon DG
- KMID: 2363698
- J Korean Med Sci.
- 2016 Apr;31(4):585-589.
- doi: 10.3346/jkms.2016.31.4.585
The aim of this study was to investigate whether the omega-3 fatty acids help to improve erectile function in an atherosclerosis-induced erectile dysfunction rat model. A total of 20 male... -
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- The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5
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Park MH, Choi KY, Min DS
- KMID: 2359887
- Exp Mol Med.
- 2015 Dec;47(12):e200.
- doi: 10.1038/emm.2015.101
Endocytosis is differentially regulated by hypoxia-inducible factor-1alpha (HIF-1alpha) and phospholipase D (PLD). However, the relationship between HIF-1alpha and PLD in endocytosis is unknown. HIF-1alpha is degraded through the prolyl hydroxylase... -
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- Hypoxia Induces Epithelial-Mesenchymal Transition in Follicular Thyroid Cancer: Involvement of Regulation of Twist by Hypoxia Inducible Factor-1alpha
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Yang YJ, Na HJ, Suh MJ, Ban MJ, Byeon HK, Kim WS, Kim JW, Choi EC, Kwon HJ, Chang JW, Koh YW
- KMID: 2345876
- Yonsei Med J.
- 2015 Nov;56(6):1503-1514.
- doi: 10.3349/ymj.2015.56.6.1503
PURPOSE: Although follicular thyroid cancer (FTC) has a relatively fair prognosis, distant metastasis sometimes results in poor prognosis and survival. There is little understanding of the mechanisms contributing to the... -
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- Urinary Hypoxia-Inducible Factor-1alpha Levels Are Associated with Histologic Chronicity Changes and Renal Function in Patients with Lupus Nephritis
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Ma C, Wei J, Zhan F, Wang R, Fu K, Wan X, Li Z
- KMID: 1776995
- Yonsei Med J.
- 2012 May;53(3):587-592.
- doi: 10.3349/ymj.2012.53.3.587
PURPOSE: Tubulointerstitial hypoxia in the kidney is considered a hallmark of injury and a mediator of the progression of tubulointerstitial fibrosis. Hypoxia-inducible factor-1alpha (HIF-1alpha), a master transcription factor in cellular... -
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- Hypoxic Regulation of VEGF, HIF-1 (alpha) in Coronary Collaterals Development
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Sung KC, Kim KS, Lee S
- KMID: 1115253
- Korean J Intern Med.
- 2005 Dec;20(4):295-302.
- doi: 10.3904/kjim.2005.20.4.295
BACKGROUND: The interindividual variability for the development of collaterals in coronary artery disease is dependent on the hypoxic induction level of VEGF. To determine whether the hypoxic induction of VEGF... -
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- Resveratrol Inhibits Hypoxia-Induced Vascular Endothelial Growth Factor Expression and Pathological Neovascularization
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Lee CS, Choi EY, Lee SC, Koh HJ, Lee JH, Chung JH
- KMID: 2345900
- Yonsei Med J.
- 2015 Nov;56(6):1678-1685.
- doi: 10.3349/ymj.2015.56.6.1678
PURPOSE: To investigate the effects of resveratrol on the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) in human adult retinal pigment epithelial (ARPE-19) cells, and... -
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- Regulation of glucose metabolism-related genes and VEGF by HIF-1alpha and HIF-1beta, but not HIF-2alpha, in gastric cancer
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Song IS, Wang AG, Yoon SY, Kim JM, Kim JH, Lee DS, Kim NS
- KMID: 756286
- Exp Mol Med.
- 2009 Jan;41(1):51-58.
- doi: 10.3858/emm.2009.41.1.007
Hypoxia-inducible factors (HIFs) are transcription factors that activate the transcription of target genes involved in crucial aspects of cancer development. This study investigated the expression of HIFs and their contribution... -
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