Korean J Physiol Pharmacol.
2013 Oct;17(5):469-477. 10.4196/kjpp.2013.17.5.469.
Effect of ECQ on Iodoacetamide-Induced Chronic Gastritis in Rats
- Affiliations
-
- 1Department of Pharmacology, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea. udsohn@cau.ac.kr
- 2Department of Pharmacognosy, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
- 3Department of Pharmacology, School of Medicine, Chung-Ang University, Seoul 156-756, Korea.
- 4Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 700-422, Korea.
- 5Department of Pharmacology, College of Medicine, Dankook University, Cheonan 330-714, Korea.
- 6Department of Medicinal Plant Science, College of Science and Engineering, Jungwon University, Chungbuk 367-805, Korea.
- KMID: 1500244
- DOI: http://doi.org/10.4196/kjpp.2013.17.5.469
Abstract
- This study investigated effect of extract containing quercetin-3-O-beta-D-glucuronopyranoside from Rumex Aquaticus Herba (ECQ) against chronic gastritis in rats. To produce chronic gastritis, the animals received a daily intra-gastric administration of 0.1 ml of 0.15% iodoacetamide (IA) solution for 7 days. Daily exposure of the gastric mucosa to IA induced both gastric lesions and significant reductions of body weight and food and water intake. These reductions recovered with treatment with ECQ for 7 days. ECQ significantly inhibited the elevation of the malondialdehyde levels and myeloperoxidase activity, which were used as indices of lipid peroxidation and neutrophil infiltration. ECQ recovered the level of glutathione, activity of superoxide dismutase (SOD), and expression of SOD-2. The increased levels of total NO concentration and iNOS expression in the IA-induced chronic gastritis were significantly reduced by treatment with ECQ. These results suggest that the ECQ has a therapeutic effect on chronic gastritis in rats by inhibitory actions on neutrophil infiltration, lipid peroxidation and various steps of reactive oxygen species (ROS) generation.
MeSH Terms
-
Animals
Body Weight
Drinking
Gastric Mucosa
Gastritis*
Glutathione
Iodoacetamide*
Lipid Peroxidation
Malondialdehyde
Neutrophil Infiltration
Peroxidase
Quercetin*
Rats*
Reactive Oxygen Species
Rumex
Superoxide Dismutase
Glutathione
Iodoacetamide
Malondialdehyde
Peroxidase
Quercetin
Reactive Oxygen Species
Superoxide Dismutase
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