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Development of Aspergillus fumigatus-induced chronic atopic dermatitis mouse model

Park A, Park H, Yu J

PURPOSE: Atopic dermatitis (AD) is the most common chronic and relapsing inflammatory skin disease with skin barrier defects and altered immune responses. Chronic inflammation leads to irreversible fibrosis in the...
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Risk Factors of Multiple Gastric Polyps according to the Histologic Classification: Prospective Observational Cohort Study

Jeong CY, Kim N, Lee HS, Yoon H, Shin CM, Park YS, Kim JW, Lee DH

BACKGROUND/AIMS: The aim of this study was to determine the risk factors of multiple gastric polyps according to the histological classification of gastric polyps. METHODS: Subjects with multiple gastric polyps (at...
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The effects of BMS-470539 on lipopolysaccharide-induced acute lung injury

Jang EA, Kim JY, Tin TD, Song JA, Lee SH, Kwak SH

BACKGROUND: Overactivation of inflammatory cells, including macrophages and neutrophils, is associated with acute lung injury. BMS-470539 is a selective agonist of melanocortin 1 receptor, which triggers the inhibition of proinflammatory...
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Are Wischnewski Spots Found Only in Hypothermia?

Noh MK, Lee S

Wischnewski spots (WS) are multiple black spots observed in the gastric mucosa at autopsy that are considered a reliable and important feature of hypothermia. Nonetheless, the frequency of WS varies...
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Anti-inflammatory Role of Mesenchymal Stem Cells in an Acute Lung Injury Mouse Model

Huh JW, Kim WY, Park YY, Lim CM, Koh Y, Kim MJ, Hong SB

BACKGROUND: Mesenchymal stem cells (MSCs) attenuate injury in various lung injury models through paracrine effects. We hypothesized that intratracheal transplantation of allogenic MSCs could attenuate lipopolysaccharide (LPS)-induced acute lung injury...
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Histopathologic Finding of Perieschar Lesions in Tsutsugamushi Disease Shows Lymphocytic Vasculitis Mimicking Angiocentric Lymphoma

Jang MS, Park JB, Lee KH, Jang JY, Yang MH, Kim JH, Hwangbo H, Lee TG, Suh KS

BACKGROUND: Tsutsugamushi disease is an acute, febrile, infectious disease caused by Orientia tsutsugamushi. Several studies investigating the histopathologic findings of eschars in tsutsugamushi disease reported leukocytoclastic vasculitis and neutrophil infiltration...
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Mouse Model of IL-17-Dominant Rhinitis Using Polyinosinic-Polycytidylic Acid

Bae JS, Kim EH, Kim JH, Mo JH

Interleukin (IL)-17 plays an important role in rhinitis and the level thereof correlates with the severity of disease. However, no mouse model for IL-17-dominant rhinitis has yet been developed. Our...
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Epithelial folliculin is involved in airway inflammation in workers exposed to toluene diisocyanate

Pham DL, Trinh TH, Ban GY, Kim SH, Park HS

Toluene diisocyanate (TDI) exposure can directly activate and damage airway epithelium. Folliculin (FLCN) is a protein expressed by human airway epithelial cells (HAECs) to maintain airway epithelial integrity and survival....
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Blocking junctional adhesion molecule C promotes the recovery of cisplatin-induced acute kidney injury

Kim SC, Ko YS, Lee HY, Kim MG, Jo SK, Cho WY

BACKGROUND/AIMS: Recent findings have demonstrated the occurrence of neutrophil transendothelial migration in the reverse direction (reverse TEM) and that endothelial junctional adhesion molecule C (JAM-C) is a negative regulator of...
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A Case of Neutrophilic Myositis

Lee KH, Han KM, Kim EJ

Neutrophilic myositis is a very rare disease histologically characterized by neutrophil infiltration of muscle tissues. We report a case of a 47-year-old man who presented with acute onset of severe...
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The Role of IL-17 in a Lipopolysaccharide-Induced Rhinitis Model

Bae JS, Kim JH, Kim EH, Mo JH

PURPOSE: Lipopolysaccharide (LPS) is a cell wall component of Gram-negative bacteria and important for pro-inflammatory mediators. This study aimed to establish a rhinitis model using ovalbumin (OVA) and LPS in...
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Superficial Angiomyxoma of the Vulva in a Postmenopausal Woman: A Case Report and Review of Literature

Lee SH, Cho YJ, Han M, Bae JW, Park JW, Oh SR, Kim S

Superficial angiomyxomas (SAMs) are rare benign cutaneous tumors that involve the subcutaneous layer. They are commonly located in the trunk, lower limbs and head or neck of women of reproductive...
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Association of autophagy related gene polymorphisms with neutrophilic airway inflammation in adult asthma

Pham DL, Kim SH, Losol P, Yang EM, Shin YS, Ye YM, Park HS

BACKGROUND/AIMS: Role of autophagy in neutrophil function and the association of autophagy and autophagy related (ATG) gene polymorphisms with asthma susceptibility were suggested. In this study, we investigated the genetic...
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Neonatal Morbidities Associated with Histologic Chorioamnionitis Defined Based on the Site and Extent of Inflammation in Very Low Birth Weight Infants

Kim SY, Choi CW, Jung E, Lee J, Lee JA, Kim H, Kim EK, Kim HS, Kim BI, Choi JH

Conflicting results on the influences of histologic chorioamnionitis (HC) on neonatal morbidities might be partly originated from using different definition of HC. The aim of this study was to determine...
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A Case of Histiocytoid Sweet Syndrome without a Hematologic Disorder

Kong TS, Han TY, Lee JH, Son SJ

  • KMID: 2046267
  • Korean J Dermatol.
  • 2015 Aug;53(7):552-555.
Histiocytoid Sweet syndrome (HSS) is a recently described rare variant of acute febrile neutrophilic dermatosis. HSS is clinically characterized by painful inflammatory plaques or nodules with high fever and neutrophilia....
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Fatal cryptosporidiosis in a calf

Baek KH, Lee HK, Lee KH, Kim HY, Park JW, Lee BR, Her JW, Lee MH, Bae YC

A calf suffering from diarrhea was admitted to the Animal and Plant Quarantine Agency for diagnostic evaluation. Postmortem examination revealed that the mesenteric lymph node was enlarged and small intestine...
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Endomyocardial Biopsy and Magnetic Resonance Imaging of Acute Myocarditis with Adult-Onset Still's Disease

Yamazoe M, Mizuno A, Suyama Y, Nishi Y, Suzuki K, Niwa K, Okada M

A 36-year-old female with a high-grade fever and epigastric abdominal pain was prescribed antibiotics, but developed hypoxia and dyspnea. An echocardiography revealed diffuse hypokinesis and massive pericardial effusion, after which...
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Schisandra Chinensis Baillon regulates the gene expression of phase II antioxidant/detoxifying enzymes in hepatic damage induced rats

Jang HI, Do GM, Lee HM, Ok HM, Shin JH, Kwon O

  • KMID: 2313739
  • Nutr Res Pract.
  • 2014 Jun;8(3):272-277.
BACKGROUND/OBJECTIVES: This study investigated the antioxidant activities and hepatoprotective effects of Schisandra chinensis Baillon extract (SCE) against tert-butyl hydroperoxide (t-BHP)-induced oxidative hepatic damage in rats. MATERIALS/METHODS: Sprague-Dawley (SD) rats were pretreated...
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Effect of ECQ on Iodoacetamide-Induced Chronic Gastritis in Rats

Lee SE, Song HJ, Park SY, Nam Y, Min CH, Lee DY, Jeong JY, Ha HS, Kim HJ, Whang WK, Jeong JH, Kim IK, Kim HR, Min YS, Sohn UD

This study investigated effect of extract containing quercetin-3-O-beta-D-glucuronopyranoside from Rumex Aquaticus Herba (ECQ) against chronic gastritis in rats. To produce chronic gastritis, the animals received a daily intra-gastric administration of...
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Comparison of the Incidences of Neonatal Morbidities by Different Criteria of Histologic Chorioamnionitis in Extremely Low Gestational Age Newborns

Son SH, Choi KY, Lee JM, Shin SH, Kim C, Kim YJ, Lee JY, Sohn JA, Lee JA, Choi CW, Kim EK, Kim HS, Kim BI, Choi JH

PURPOSE: The objective of the study was to compare the incidences of the neonatal morbidity, using the various criteria of histologic chorioamnionitis (HC) in the extremely low gestational age newborns...
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