Korean J Dermatol.
2007 Jul;45(7):754-757.
A Case of Histiocytoid Sweet's Syndrome with Myelodysplastic Syndrome
- Affiliations
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- 1Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea. Dbang@yumc.yonsei.ac.kr
- 2Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
Abstract
- Sweet's syndrome is an acute febrile neutrophilic dermatosis that occurs with malignant disease, mainly myeloid hemopathies, in about 20% of cases. When associated with myelodysplasia, clinical and histologic features of Sweet's syndrome can be atypical; however its significance is still debated. We encountered a case of Sweet's syndrome associated with myelodysplastic syndrome in a 63-year-old woman. The clinical presentation strongly suggested Sweet's syndrome but, histopathologic examination showed dense histiocytic infiltration with prominent upper dermal edema and little neutrophil infiltration. In the evaluation for atypical histopathology and laboratory abnormalities, she was diagnosed with myleodysplastic syndrome by peripheral blood smear and bone marrow biopsy. Histiocytoid Sweet's syndrome is a currently accepted concept and probably has a close relation with underlying myeloid hemopathies.
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