Korean J Dermatol.  2017 Feb;55(2):124-128.

A Case of Malignancy-associated Histiocytoid Sweet Syndrome in a Patient with AML

Affiliations
  • 1Department of Dermatology, College of Medicine, Dong-A University, Busan, Korea. khkim@dau.ac.kr

Abstract

Sweet syndrome is a disorder characterized by painful, erythematous, cutaneous plaques and nodules of rapid onset accompanied by fever, leukocytosis, and neutrophilia. We encountered a case of a recurrent histiocytoid Sweet syndrome in a patient with acute myeloid leukemia (AML). A 64-year-old Korean man was diagnosed with complete remission of AML and had symptomatic nodules and plaques on the dorsal sides of both hands. Approximately 3 years prior, he also had symptomatic plaques at the same site and had been diagnosed with MDS (Myelodysplastic syndrome). We performed a biopsy and diagnosed this case as a malignancy-associated histiocytoid Sweet syndrome. Most Sweet syndrome cases are acute; in contrast, this case was chronic with a relapse. In addition, histopathologic examination showed a dense histiocytic infiltration. These histiocytoid cells are usually misinterpreted as histiocytes; however, they are actually immature myeloid cells. Herein, we report a case of a recurrent malignancy-associated histiocytoid Sweet syndrome in a patient with a hematologic disorder.

Keyword

Malignancy-associated Sweet syndrome; Histiocytoid Sweet syndrome; AML

MeSH Terms

Biopsy
Fever
Hand
Histiocytes
Humans
Leukemia, Myeloid, Acute
Leukocytosis
Middle Aged
Myeloid Cells
Recurrence
Sweet Syndrome*
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