Korean J Dermatol.  2013 Jul;51(7):531-535.

A Case of Histiocytoid Sweet Syndrome Developed in the Patient with Pure White Cell Aplasia

Affiliations
  • 1Department of Dermatology, School of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Korea. tyyoon@chungbuk.ac.kr
  • 2Department of Internal Medicine, School of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Korea.

Abstract

Histiocytoid Sweet syndrome (HSS) is a rare inflammatory disease that has recently been described as a variant of Sweet syndrome. Histopathologically, HSS is characterized by papillary dermal edema with infiltration of histiocytoid cells into the upper dermis. The histiocytoid cells are easily misinterpreted as histiocyte, but in fact, they are immature myeloid cells. To demonstrate cells of myeloid lineage, specific staining must be performed, such as myeloperoxidase (MPO). To date, there are several HSS cases associated with hematological malignancy, drugs, and chronic inflammatory diseases. But, in Korea, only one case has been reported so far. Herein, we report a case of HSS developed in the patient with pure white cell aplasia and review the relevant literature.

Keyword

Histiocytoid Sweet syndrome; Myeloperoxidase

MeSH Terms

Dermis
Edema
Hematologic Neoplasms
Histiocytes
Humans
Korea
Myeloid Cells
Peroxidase
Sweet Syndrome
Peroxidase
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