- Reduced Osteogenic Differentiation Potential In Vivo in Acute Myeloid Leukaemia Patients Correlates with Decreased BMP4 Expression in Mesenchymal Stromal Cells
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Azevedo PL, Dias RB, Nogueira LP, Maradei S, Bigni R, Aragao JSR, Abdelhay E, Binato R
- KMID: 2529837
- Int J Stem Cells.
- 2022 May;15(2):227-232.
- doi: 10.15283/ijsc21138
The osteogenic differentiation potential of mesenchymal stromal cells (hMSCs) is an essential process for the haematopoiesis and the maintenance of haematopoietic stem cells (HSCs). Therefore, the aim of this work... -
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- Peptides Targeting Fms-Related Tyrosine Kinase-4 Activate the Function of Natural Killer Cells in Acute Myeloid Leukemia
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Park S, Kim HJ, Hwang HS, Han AR
- KMID: 2522559
- Int J Stem Cells.
- 2021 Nov;14(4):400-409.
- doi: 10.15283/ijsc21083
Background and Objectives: The increased expression for the Fms-related tyrosine kinase-4 (FLT-4, known as VEGFR-3) is relevant to dysfunctional natural killer (NK) cells in acute myeloid leukemia (AML). MAZ51 (M),... -
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- Next-Generation Sequencing Myeloid Panel Test for Patients with AML and MDS: Experience in a Tertiary Care Hospital
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Mun SH, Suh HS, Jeon CH, Lee AJ, Yoo EH, Kim SG
- KMID: 2525779
- Lab Med Online.
- 2021 Jan;11(1):40-46.
- doi: 10.47429/lmo.2021.11.1.40
Background: Next-generation sequencing (NGS) technology can be used for detecting gene mutations in various patients. The NGS myeloid panel test can be specifically used for patients with a myeloid neoplasm.... -
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- Real-world evidence on the strategy of olmesartan-based triple single-pill combination in Korean hypertensive patients: a prospective, multicenter, observational study (RESOLVE-PRO)
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Sohn IS, Ihm SH, Kim GH, Park SM, Hong BK, Lee CH, Lee SH, Chang DI, Joo SP, Lee SC, Lee Yh, Jeon DW, Jung KT, Rhee SJ, Cho YJ, Kim CJ, I
- KMID: 2522301
- Clin Hypertens.
- 2021;27(1):21.
- doi: 10.1186/s40885-021-00177-z
Background In this prospective, multicenter, non-comparative observational study, the effectiveness and safety of the triple single-pill combination (SPC) of olmesartan/amlodipine/hydrochlorothiazide (OM/AML/HCTZ) were evaluated in a real clinical practice setting in Korean... -
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- Acute Monoblastic Leukemia with t(11;17)(q23;q21): Fusion of the KMT2A(MLL) and MLLT6(AF17) Genes
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Park CG, Mun SH, Lee AJ, Jeon CH, Suh HS, Kim SG
- KMID: 2458689
- Lab Med Online.
- 2019 Oct;9(4):258-262.
- doi: 10.3343/lmo.2019.9.4.258
The KMT2A (formerly MLL) gene is associated with at least 10% of all cases of acute leukemia. More than 80 translocation partner genes of KMT2A have been discovered to date,... -
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- Overexpression of indoleamine 2,3-dioxygenase correlates with regulatory T cell phenotype in acute myeloid leukemia patients with normal karyotype
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Arandi N, Ramzi M, Safaei F, Monabati A
- KMID: 2429303
- Blood Res.
- 2018 Dec;53(4):294-298.
- doi: 10.5045/br.2018.53.4.294
BACKGROUND: Production of immunosuppressive enzymes such as indoleamine 2,3-dioxygenase (IDO) is one of the strategies employed by hematologic malignancies, including acute myeloid leukemia (AML), to circumvent immune surveillance. Moreover, IDO... -
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- Spectrum of mitochondrial genome instability and implication of mitochondrial haplogroups in Korean patients with acute myeloid leukemia
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Kim HR, Kang MG, Lee YE, Na BR, Noh MS, Yang SH, Shin JH, Shin MG
- KMID: 2429325
- Blood Res.
- 2018 Sep;53(3):240-249.
- doi: 10.5045/br.2018.53.3.240
BACKGROUND: Mitochondrial DNA (mtDNA) mutations may regulate the progression and chemosensitivity of leukemia. Few studies regarding mitochondrial aberrations and haplogroups in acute myeloid leukemia (AML) and their clinical impacts have... -
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- A Case of Malignancy-associated Histiocytoid Sweet Syndrome in a Patient with AML
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Seo JW, Kim TH, Choi SH, Ha SM, Song KH, Kim KH
- KMID: 2371085
- Korean J Dermatol.
- 2017 Feb;55(2):124-128.
Sweet syndrome is a disorder characterized by painful, erythematous, cutaneous plaques and nodules of rapid onset accompanied by fever, leukocytosis, and neutrophilia. We encountered a case of a recurrent histiocytoid... -
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- Decitabine as a First-Line Treatment for Older Adults Newly Diagnosed with Acute Myeloid Leukemia
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Park H, Chung H, Lee J, Jang J, Kim Y, Kim SJ, Kim JS, Min YH, Cheong JW
- KMID: 2374186
- Yonsei Med J.
- 2017 Jan;58(1):35-42.
- doi: 10.3349/ymj.2017.58.1.35
PURPOSE: Decitabine, a DNA hypomethylating agent, was recently approved for use in Korea for older adults with acute myeloid leukemia (AML) who are not candidates for standard chemotherapy. This study... -
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- Correlation of NPM1 Type A Mutation Burden With Clinical Status and Outcomes in Acute Myeloid Leukemia Patients With Mutated NPM1 Type A
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Jo SY, Park SH, Kim IS, Yi J, Kim HH, Chang CL, Lee EY, Cho YU, Jang S, Park CJ, Chi HS
- KMID: 2373568
- Ann Lab Med.
- 2016 Sep;36(5):399-404.
- doi: 10.3343/alm.2016.36.5.399
BACKGROUND: Nucleophosmin gene (NPM1) mutation may be a good molecular marker for assessing the clinical status and predicting the outcomes in AML patients. We evaluated the applicability of NPM1 type... -
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- Evaluation of prognostic factors in patients with relapsed AML: Clonal evolution versus residual disease
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Kim H, Seol YM, Song MK, Choi YJ, Shin HJ, Park SH, Lee EY, Chung JS
- KMID: 2353498
- Blood Res.
- 2016 Sep;51(3):175-180.
- doi: 10.5045/br.2016.51.3.175
BACKGROUND: It is widely known that the prognosis of acute myeloid leukemia (AML) depends on chromosomal abnormalities. The majority of AML patients relapse and experience a dismal disease course despite... -
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- Alteration of the SETBP1 Gene and Splicing Pathway Genes SF3B1, U2AF1, and SRSF2 in Childhood Acute Myeloid Leukemia
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Choi HW, Kim HR, Baek HJ, Kook H, Cho D, Shin JH, Suh SP, Ryang DW, Shin MG
- KMID: 2363158
- Ann Lab Med.
- 2015 Jan;35(1):118-122.
- doi: 10.3343/alm.2015.35.1.118
BACKGROUND: Recurrent somatic SET-binding protein 1 (SETBP1) and splicing pathway gene mutations have recently been found in atypical chronic myeloid leukemia and other hematologic malignancies. These mutations have been comprehensively... -
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- A Novel Translocation Involving RUNX1 and HOXA Gene Clusters in a Case of Acute Myeloid Leukemia with t(7;21)(p15;q22)
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Moon Y, Horsman DE, Humphries , Park G
- KMID: 1493618
- Immune Netw.
- 2013 Oct;13(5):222-226.
- doi: 10.4110/in.2013.13.5.222
Translocations involving chromosome 21q22 are frequently observed in hematologic malignancies including acute myeloid leukemia (AML), most of which have been known to be involved in malignant transformation through transcriptional dysregulation... -
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- Evaluation of prognostic factors in patients with therapy-related acute myeloid leukemia
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Park SH, Chi HS, Cho YU, Jang S, Park CJ
- KMID: 2270704
- Blood Res.
- 2013 Sep;48(3):185-192.
- doi: 10.5045/br.2013.48.3.185
BACKGROUND: Therapy-related AML (t-AML) occurs as a late complication of chemotherapy administered to treat a prior disorder. Prognostic factors affecting the clinical outcome in t-AML have not yet been clearly... -
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- N-ras Mutation Detection by Pyrosequencing in Adult Patients with Acute Myeloid Leukemia at a Single Institution
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Jeong JH, Park SH, Park MJ, Kim MJ, Kim KH, Park PW, Seo YH, Lee JH, Park J, Hong J, Ahn JY
- KMID: 1781320
- Ann Lab Med.
- 2013 May;33(3):159-166.
- doi: 10.3343/alm.2013.33.3.159
BACKGROUND: N-ras mutations are one of the most commonly detected abnormalities of myeloid origin. N-ras mutations result in a constitutively active N-ras protein that induces uncontrolled cell proliferation and inhibits... -
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- Identification of Two Novel NPM1 Mutations in Patients with Acute Myeloid Leukemia
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Jeon Y, Seo SW, Park S, Park S, Kim SY, Ra EK, Park SS, Seong MW
- KMID: 1781299
- Ann Lab Med.
- 2013 Jan;33(1):60-64.
- doi: 10.3343/alm.2013.33.1.60
BACKGROUND: Genetic abnormalities in adult AML are caused most frequently by somatic mutations in exon 12 of the NPM1 gene, which is observed in approximately 35% of AML patients and... -
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- Total Hip Arthroplasty Using AML(R) Prosthesis: Minimum 20-Year Follow-Up of the Patients
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Lim CH, Chung YY, Kim DH, Ahn SH, Kim MY
- KMID: 2185307
- J Korean Orthop Assoc.
- 2012 Dec;47(6):439-444.
- doi: 10.4055/jkoa.2012.47.6.439
PURPOSE: We reviewed the radiological outcomes and survival rate of the total hip arthroplasty (THA) with AML(R) (Anatomic Medullary Locking, DePuy, Warsaw, IN, USA) hip prosthesis on long-term follow-up. MATERIALS AND... -
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- Additional Genomic Aberrations Identified by Single Nucleotide Polymorphism Array-Based Karyotyping in an Acute Myeloid Leukemia Case with Isolated del(20q) Abnormality
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Hahm C, Mun YC, Seong CM, Chung WS, Huh J
- KMID: 2434489
- Ann Lab Med.
- 2012 Nov;32(6):445-449.
Prognosis is known to be better in cases with isolated chromosomal abnormalities than in those with complex karyotypes. Accordingly, del(20q) as an isolated abnormality must be distinguished from cases in... -
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- Effects of granulocyte-colony stimulating factor and the expression of its receptor on various malignant cells
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Moon HW, Kim TY, Oh BR, Hwang SM, Kwon J, Ku JL, Lee DS
- KMID: 2251957
- Korean J Hematol.
- 2012 Sep;47(3):219-224.
- doi: 10.5045/kjh.2012.47.3.219
BACKGROUND: Granulocyte-colony stimulating factor (G-CSF) is extensively used to improve neutrophil count during anti-cancer chemotherapy. We investigated the effects of G-CSF on several leukemic cell lines and screened for the... -
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- Ring Chromosome 5 in Acute Myeloid Leukemia Defined by Whole-genome Single Nucleotide Polymorphism Array
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Huh J, Mun YC, Chung WS, Seong CM
- KMID: 1380093
- Ann Lab Med.
- 2012 Jul;32(4):307-311.
- doi: 10.3343/alm.2012.32.4.307
Chromosomes forming a corresponding ring cannot be clearly defined by conventional cytogenetics or FISH. Karyotypic analyses using whole-genome single nucleotide polymorphism arrays (SNP-A) may result in the identification of previously... -
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