J Korean Assoc Oral Maxillofac Surg.
2006 Jun;32(3):189-199.
Development of biocompatible dressing material made of collagen and amniotic membrane and wound healing experiment in rat
- Affiliations
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- 1Department of Oral and Maxillofacial Surgery, College of Medicine, Ulsan University, Korea.
- 2Department of Oral and Maxillofacial Surgery, College of Dentistry, Seoul National University, Korea. leejongh@plaza.snu.ac.kr
- 3Bioland Incorporation, Korea.
Abstract
- <0.05). 4. Histologic examination revealed that AM protected leukocyte infiltration and epithelial migration was nearly completed at 4 weeks. Terudermis(R) group showed mild neutrophil infiltration until 2 weeks and completion of epithelization at 4 weeks. Control group showed massive leukocyte infiltration until 4 weeks. 5. Microvessels were increased sharply at 1 week and control group at 1 and 4 week showed significant differences with Terudermis(R) group of same interval(p<0.05) but no differences were found with AM group(p<0.05).
CONCLUSION
EGF and EGF-R were well preserved in freeze-dried AM. AM attached to collagen acted as excellent biologic dressing which had similar effect with Terudermis(R). AM showed anti-inflammatory action and healing was completed at 4 weeks after full-thickness skin defect.
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