J Korean Soc Hypertens.  2011 Dec;17(4):133-147. 10.5646/jksh.2011.17.4.133.

Cyclophilin A: A Mediator of Cardiovascular Pathology

• Soe NN
• Berk BC

• KMID: 1492131
• DOI: http://doi.org/10.5646/jksh.2011.17.4.133

Abstract

Cyclophilin A (CyPA) is a 17 kDa, ubiquitously expressed multifunctional protein that possesses peptidylprolyl cis-trans isomerase activity and scaffold function. Its expression is increased in inflammatory conditions including rheumatoid arthritis, autoimmune disease and cancer. Intracellular CyPA regulates protein trafficking, signal transduction, transcription regulation and the activity of certain other proteins. Secreted CyPA activates cardiovascular cells resulting in a variety of cardiovascular diseases; including vascular remodeling, abdominal aortic aneurysms formation, atherosclerosis, cardiac hypertrophy and myocardial ischemic reperfusion injury.

Keyword

Cyclophilin A; Oxidative stress; Cardiovascular diseases

MeSH Terms

Aortic Aneurysm, Abdominal
Arthritis, Rheumatoid
Atherosclerosis
Autoimmune Diseases
Cardiomegaly
Cardiovascular Diseases
Cyclophilin A
Cyclophilins
Myocardial Reperfusion Injury
Oxidative Stress
Protein Transport
Proteins
Quaternary Ammonium Compounds
Signal Transduction
Cyclophilin A
Cyclophilins
Proteins
Quaternary Ammonium Compounds

Figure

• 

  Fig. 1. Cyclophilin A (CyPA) effects on vascular smooth muscle (VSMC), endothelial cells (EC) and T cells. VCAM-1, vascular cell adhesion molecule-1; IFN, interferon; IL, interleukin.

• 

  Fig. 2. Immune modulation of T cell function. (A) Th2 inhibits Th1 responses. (B) T regs regulate both Th1 and Th2 responses. IFN, interferon; IL, interleukin; TGF, transforming growth factor.

• 

  Fig. 3. Mechanism of cyclophilin A (CyPA) regulation on cardiovascular cells. ROS, reactive oxygen species; VSMC, vascular smooth muscle; EC, endothelial cells.

Reference

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