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Cyclophilin A: A Mediator of Cardiovascular Pathology

Soe NN, Berk BC

Cyclophilin A (CyPA) is a 17 kDa, ubiquitously expressed multifunctional protein that possesses peptidylprolyl cis-trans isomerase activity and scaffold function. Its expression is increased in inflammatory conditions including rheumatoid arthritis,...
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Cyclophilin A as a New Therapeutic Target for Hepatitis C Virus-induced Hepatocellular Carcinoma

Lee J

Hepatocellular carcinoma (HCC) related to hepatitis B virus (HBV) and hepatitis C virus (HCV) infections is thought to account for more than 80% of primary liver cancers. Both HBV and...
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The Stimulation of CD147 Induces MMP-9 Expression through ERK and NF-kappaB in Macrophages: Implication for Atherosclerosis

Kim JY, Kim WJ, Kim H, Suk K, Lee WH

BACKGROUND: CD147, as a cellular receptor for cyclophilin A (CypA), is a multifunctional protein involved in tumor invasion, inflammation, tissue remodeling, neural function, and reproduction. Recent observations showing the expression...
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CsA Affects the Rat Submandibular Glands via Regulating the CypA Expression

Lee EJ, Hong YG, Yoo HI, Yang SY, Kang JH, Kim MS, Kim SH

  • KMID: 1431128
  • Int J Oral Biol.
  • 2012 Dec;37(4):153-159.
The effects of the an immunosuppressive drug cyclosporine A (CsA), on the salivary gland are largely unknown, even though clinical trials for the stimulation of salivation using CsA have been...
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