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Forensic Consideration of Myocardial Reperfusion Injury Associated with Cardiac Valves Replacement and Coronary Artery Bypass Graft: A Case Report

Eom M, Choi YD, Kang GH, Min BW, Kim DH, Kim YS, Lee HY

  • KMID: 1928085
  • Korean J Leg Med.
  • 2005 Oct;29(2):146-151.
The most effective ways to salvage ischemic myocardium threatened by infarction is to restore tissue perfusion as rapidly as possible. These are best accomplished by restoration of coronary flow(reperfusion) by...
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Mechanism of Ischemia and Reperfusion Injury to the Heart: From the Viewpoint of Nitric Oxide and Mitochondria

Ha SJ, Kim W

After an acute myocardial infarction, early and successful myocardial reperfusion is the most effective strategy for reducing the size of a myocardial infarct and improving the clinical outcome. However, the...
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Effects of Ivabradine on Left Ventricular Systolic Function and Cardiac Fibrosis in Rat Myocardial Ischemia-Reperfusion Model

Kim HB, Hong YJ, Park HJ, Ahn Y, Jeong MH

We evaluated the effects of Ivabradine on left ventricle (LV) ejection fraction (EF) and LV infarcted tissue in the rat myocardial ischemia-reperfusion model. Twenty rats were randomly assigned to group...
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Apoptosis in Ischemia-Reperfused Myocardium of Rabbit

Kim YK, Han DS, Lee MY, Kim MA, Lee HC, Park YT, Kim SH, Kim SS

BACKGROUND: Apoptosis, as opposed to necrosis, is a active and regulated mode of cell death. Persistent myocardial ischemia results in necrosis. The most effective method to limit ischemic myocardial injury...
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Effects of Sodium Nitroprusside on Functional Recovery of Stunned Myocardium in Dogs

Yoo KY, Park CJ, Yoon OJ

Ischemia/reperfusion injury (myocardial stunning) may be mediated by oxygen derived-free radicals. Sodium nitroprusside (SNP), NO-donor, is known to reduce superoxide concentrations in isolated vascular tissue. To explore the efficacy of...
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Nicardipine Augments Local Myocardial Perfusion after Coronary Artery Reperfusion in Dogs

Jang YH, Kim JM

Nicardipine is a potent coronary and systemic vasodilator without depression of ventricular function. We investigated the changes in local myocardial perfusion (LMP) according to the nicardipine administration after coronary reperfusion...
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Therapeutic Hypothermia for Cardioprotection in Acute Myocardial Infarction

Kang IS, Fumiaki I, Pyun WB

Mild therapeutic hypothermia of 32-35degrees C improved neurologic outcomes in outside hospital cardiac arrest survivor. Furthermore, in experimental studies on infarcted model and pilot studies on conscious patients with acute...
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The Effect of High Dose Melatonin on Cardiac Ischemia-reperfusion Injury

Ceyran H, Narin F, Narin N, Akgun H, Ceyran AB, Ozturk F, Akcali Y

PURPOSE: Melatonin, the most potent scavenger of toxic free radicals, has been found to be effective in protecting against pathological states due to the release of reactive oxygen species. This...
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Experimental Studies on the Effect of Ginsenoside Rg1 Mixtures in an Isolated Rat Heart after Ischemic Arrest and Reperfusion

Kim DW, Shin WS, Lee JY, Kim BS, Cho KS, You SY

  • KMID: 2062113
  • Korean J Thorac Cardiovasc Surg.
  • 1998 Jun;31(6):567-575.
Panax Ginseng C.A. Meyer has been known for hundreds of years as the most valuable drug having mysterious effects among all the herbal medicines and plants in Korea. Also, many...
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The Protective Effect of Intravenous Adenosine on Myocardial Reperfusion Injury in Feline Heart Model

Shin DG, Kim YJ, Shim BS, Lee JH, Park CM, Kim MJ

BACKGROUND: Among the various mechanisms of Myocardial reperfusion injuries, neutrophil is thought to be one of them. Endogenous coronary vasodilator adenosine is known to have myocardial protective effect through variable...
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Effect of reperfusion with leukocyte-depleted blood on the expression of myocardial vascular cell adhesion molecule-1 ( VCAM-1 ) and myocardial function in isolated working heart perfusion model

Lee JR, Suk CJ, Suh JW, Han JJ

  • KMID: 1581858
  • Korean J Thorac Cardiovasc Surg.
  • 2000 Mar;33(3):213-220.
BACKGROUND: Adhesion of leukocytes to myocardium or vascular endothelium has been known as an importation initial step in the ischemia-reperfusion injury which may affect the cardiac function. Therefore, leukocyte-depleted reperfusion may inhibit...
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Protective Effect of Sauchinone Against Regional Myocardial Ischemia/Reperfusion Injury: Inhibition of p38 MAPK and JNK Death Signaling Pathways

Kim SJ, Jeong CW, Bae HB, Kwak SH, Son JK, Seo CS, Lee HJ, Lee J, Yoo KY

Sauchinone has been known to have anti-inflammatory and antioxidant effects. We determined whether sauchinone is beneficial in regional myocardial ischemia/reperfusion (I/R) injury. Rats were subjected to 20 min occlusion of...
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Cardioprotective Effects of Alpha-Lipoic Acid on Myocardial Reperfusion Injury: Suppression of Reactive Oxygen Species Generation and Activation of Mitogen-Activated Protein Kinase

Oh SK, Yun KH, Yoo NJ, Kim NH, Kim MS, Park BR, Jeong JW

BACKGROUND AND OBJECTIVES: Reactive oxygen species (ROS) and mitogen-activated protein (MAP) kinase play an important role in the development of myocardial reperfusion injury. In this study, we examined whether treatment...
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Myocardial protection by recombinant soluble P-selectin glycoprotein ligand-1: Suppression of neutrophil and platelet interaction following ischemia and reperfusion

Ham SS, Jang YY, Song JH, Lee HM, Kim KJ, Hong JS, Shin YK

  • KMID: 1581030
  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):515-523.
Polymorphonuclear leukocytes (PMNs) play an important role in myocardial ischemia/reperfusion (MI/R) injury. Moreover, platelets are also important blood cells that can aggravate myocardial ischemic injury. This study was designed to test the effects...
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Attenuation of Reperfusion Injury with Angiotensin AT1 Receptor Blockade in Rat Myocardial Ischemic Mbdel

Choi JY, Choi DJ, Ahn H

  • KMID: 2062575
  • Korean J Thorac Cardiovasc Surg.
  • 2001 Mar;34(3):203-212.
BACKGROUND: Although AT1 receptor antagonist can protect myocardium against ischemia/reperfusion injury at the cellular level, the in vivo effect and the mechanisms of this effect have not yet been characterized....
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Influence of the Angiotensin II AT1 Receptor Antagonist on Reperfusion Injury in Rat Myocardial Ischemia Model

Nam JH, Lee JE, Kim EJ, Park SJ, Jin BC, Park TJ, Choi JY, Choi DJ, Seo BG

BACKGROUND AND OBJECTIVES: The protective effect of angiotensin converting enzyme (ACE) inhibitor against ischemia/reperfusion injury has been demonstrated in animal models, however the effect of AT1 receptor antagonist is contradictory....
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Anti-arrhythmic Effect of Melatonin in Reperfusion-induced Arrhythmia

Cho GC, Kim W, Hong JS, Lee MW, Jang SE, Oh SH, Lim KS

  • KMID: 2331315
  • J Korean Soc Emerg Med.
  • 2001 Dec;12(4):393-399.
BACKGROUND: Recently, a few studies demonstrated that melatonin reduced the severity of myocardial reperfusion injuries, such as reperfusion arrhythmias. However, it is uncertain whether the melatonin reduces reperfusion arrhythmias in...
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Mitochondrial Dynamics in the Heart as a Novel Therapeutic Target for Cardioprotection

Hwang SJ, Kim W

Traditionally, mitochondria have been regarded solely as energy generators for cells; however, accumulating data have demonstrated that these complex organelles play a variety of roles within the cardiomyocyte that extend...
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Cardioprotective signaling cascade of A2 adenosine receptor agonist 5'-N-ethylcarboxaminidoadenosine against myocardial reperfusion injury

Lee YC, Jang YH, Kim CJ, Kim JM

BACKGROUND: This experiments investigated the signaling cascade responsible for anti-infarct effect by an A2 adenosine receptor (AR) agonist 5'-N-Ethylcarboxaminidoadenosine (NECA). METHODS: Langendorff perfused isolated rat hearts were subjected to 30 minutes...
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Effect of Superoxide Dismutase on Apoptosis in Ischemia-Reperfused Myocardium of Rabbit

Kim YK, Park YT, Kim S

BACKGROUND: Recently involvenment of apoptosis, or programmed cell death, has been suggested in myocardial reperfusion injury. Free radicals are one of the inducers of apoptosis, and superoxide dismutase(SOD), a oxygen...
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