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Laboratory Monitoring of Biological Therapies in Rheumatology: The Role of Immunogenicity

Benucci M, Grossi V, Manfredi M, Damiani A, Infantino , Moscato P, Cinquanta , Gremese E, Tolusso B, Petricca L, Fedele AL, Alivernini S, Atzeni F, Minisola G, Verna R

Biological drugs, such as proteins and immunogens, are increasingly used to treat various diseases, including tumors and autoimmune diseases, and biological molecules have almost completely replaced synthetic drugs in rheumatology....
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Clinical Characteristics and Treatment of Immune-Related Adverse Events of Immune Checkpoint Inhibitors

Choi J, Lee SY

Immune checkpoint inhibitors (ICIs) have been changing the paradigm of cancer treatment. However, immune-related adverse effects (irAEs) have also increased with the exponential increase in the use of ICIs. ICIs...
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Regulatory T Cells in Tumor Microenvironment and Approach for Anticancer Immunotherapy

Kim JH, Kim BS, Lee SK

Tregs have a role in immunological tolerance and immune homeostasis by suppressing immune reactions, and its therapeutic potential is critical in autoimmune diseases and cancers. There have been multiple studies...
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Diffuse Systemic Sclerosis in a Patient with Primary Biliary Cirrhosis and Autoimmune Hepatitis Overlap Syndrome: A Case Report

Han HS, Ahn GR, Kim HJ, Park KY, Li K, Seo SJ

Systemic sclerosis (SSc) is a chronic systemic disease of unknown etiology characterized by vasculopathy, excessive accumulation of extracellular matrix, and fibrosis of the skin and other internal organs. Although its...
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Rifampin-Induced Immune Hemolytic Anemia during Treatment of Pulmonary Tuberculosis in a Patient with Primary Sjogren's Syndrome

Souk JW, Kim YK, Jang GE, Jeong HS, Uh ST, Kim KU, Koo SM, Lee BY, Noh H, Shin WY, Shin JW, Jin SY

Drug-induced immune hemolytic anemia is a rare disease that occurs in 1 in 1 million individuals of the general population. Rifampin-induced immune hemolytic anemia is caused by drug-dependent antibodies and...
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Recurrent Optic Neuritis and Acute Encephalopathy with Myelin Oligodendrocyte Glycoprotein Antibodies in a Korean Child

Hwang JE, Kim SH, Park S

Myelin oligodendrocyte glycoprotein (MOG) antibody-associated diseases are reported to have distinct pathogenic mechanisms, clinical courses, and therapeutic implications in comparison to other acquired demyelinating syndromes. Here, we report the case...
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A novel compound heterozygous mutation of the AIRE gene in a patient with autoimmune polyendocrine syndrome type 1

Suh J, Choi HS, Kwon A, Chae HW, Lee JS, Kim HS

Autoimmune polyendocrine syndrome type 1 (APS-1), or autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy is a rare, autosomal recessive autoimmune disease caused by a mutation of the autoimmune regulator (AIRE) gene. The main symptom...
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Autoantibody-Mediated Dysfunction of Salivary Glands Leads to Xerostomia in SKG Mice

Choi SS, Jang E, Jang K, Jung SJ, Hwang KG, Youn J

Sjögren's syndrome (SS) is a chronic heterogeneous disease that mainly affects exocrine glands, leading to sicca syndromes such as xerostomia. Despite the second highest prevalence rate among systemic autoimmune diseases,...
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Treatment of Graves' Ophthalmopathy

Lee JK

Graves' ophthalmopathy (GO) is an autoimmune disease associated with orbital inflammation and fibrosis which can result in lid retraction, soft tissue swelling, and proptosis. Treatment should rely on a thorough...
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Systemic Sclerosis and Microbiota: Overview of Current Research Trends and Future Perspective

Kim S, Chun SH, Park HJ, Lee SI

The commensal microbiota contributes to the maintenance of immune homeostasis in the human body. Autoimmunity can be aggravated or alleviated by the microbiota, which affects both innate and adaptive immune...
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Diagnostic Challenge: Primary Bone Marrow Diffuse Large B-cell Lymphoma Mimicking Systemic Autoimmune Diseases

Oh J, Kim Y, Lee ST, Lee KA

No abstract available.
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Diagnosis of Systemic Scleroderma in a Patient with Leg Ulcer

Ju GS, Son KM, Choi WY, Cheon JS

Systemic scleroderma is an autoimmune disease that affects connective tissue in internal organs and the skin with thickening and fibrosis. When afflicting internal organs, the disease leads to reduced quality...
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Stiff-Person Syndrome: Diagnostic Difficulty

Lee JK, Kang C, Kim SB, An BK, Lee GS

Stiff-person syndrome is a rare disorder, and the natural history of the syndrome has not been completely ascertained. The symptoms range from mild to severe and can progress over time:...
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Urticaria: Classification and Diagnosis

Ye YM

Urticaria is a common cutaneous disease characterized by recurrent and transient wheals and pruritus, sometimes accompanied angioedema. The classification of urticaria is based on the duration of the disease and...
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Treatment of Hidradenitis Suppurativa Patient with Klinefelter Syndrome by Adalimumab

Shin JY, Hong JY, Lee HJ, Sim CY, Park YL, Lee JS, Lee SY, Kim JE

Hidradenitis suppurativa (HS) is a chronic, inflammatory and painful skin disease with recurrent nodules and tracts involving the intertriginous regions. It is known that the patient with HS shows an...
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Clinical Relevance for Serum Cold-Inducible RNA-Binding Protein Level in Alopecia Areata

Shin JM, Ko JW, Kwon IS, Choi JW, Hong D, Lee JH, Seo YJ, Kim CD, Lee JH, Lee Y, Park KD

BACKGROUND: Alopecia areata (AA), a chronic, relapsing hair-loss disorder, is considered to be a T-cell-mediated autoimmune disease. Cold-inducible RNA-binding protein (CIRP) belongs to a family of cold-shock proteins that respond...
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A Novel Immunomodulatory Mechanism Dependent on Acetylcholine Secreted by Human Bone Marrow-derived Mesenchymal Stem Cells

Yi TG, Cho YK, Lee HJ, Kim J, Jeon MS, Ham DS, Kim WC, Song SU

BACKGROUND AND OBJECTIVES: Mesenchymal stem cells (MSCs) are used to treat autoimmune or inflammatory diseases. Our aim was to determine the immunomodulatory mechanisms elicited by MSCs during inflammation. METHODS AND RESULTS:...
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The evaluation of cellular immune function in elderly patients with systemic lupus erythematosus

Men K, Chen Y, Zhang J, Wei D

BACKGROUND/AIMS: To evaluate cellular immune function in systemic lupus erythematosus (SLE) patients over 60 years old, the association between antinuclear antibody (ANA) titers and the ratio of CD4⁺/CD8⁺ was analyzed...
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Systematic Review on Sanitary Pads and Female Health

Woo J, Kim S, Kim H, Jeong KS, Kim E, Ha E

The majority of South Korean females use sanitary pads, which contain various organic solvents which could be excreted before and during their menstruation. However, they are not provided with findings...
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Autoimmune Diseases and Gastric Cancer Risk: A Systematic Review and Meta-Analysis

Song M, Latorre G, Ivanovic-Zuvic D, Camargo MC, Rabkin CS

PURPOSE: Autoimmunity is an alternative etiology of gastric inflammation, the initiating event in the gastric carcinogenic cascade. This mechanism may be an increasingly important cause of gastric cancer with the...
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