J Korean Endocr Soc.
2010 Mar;25(1):68-71. 10.3803/jkes.2010.25.1.68.
Autoimmune Thyroiditis during Antiviral Therapy with Peginterferon
- Affiliations
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- 1Department of Internal Medicine, Yonsei University College of Medicine, Korea.
- KMID: 2177864
- DOI: http://doi.org/10.3803/jkes.2010.25.1.68
Abstract
- Combination treatment with pegylated interferon and ribavirin has been established as a standard therapy for chronic hepatitis C. Although interferon therapy is relatively safe, an important side effect is the induction of autoantibodies and autoimmune disease, especially autoimmune thyroid disease. Interferon associated autoimmune thyroid disease can consist of autoimmune hypothyroidism, Graves' disease, and destructive thyroiditis. Thyroid disease may lead to dose reduction or discontinuation of therapy.
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