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Established and Emerging Mechanisms of Diabetic Cardiomyopathy

Gollmer J, Zirlik A, Bugger H

Diabetes mellitus increases the risk for the development of heart failure even in the absence of coronary artery disease and hypertension, a cardiac entity termed diabetic cardiomyopathy (DC). Clinically, DC...
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Primary Cardiac Hemangioendothelioma in an Infant: A Case Report

Seo JW, Song MK, Park SH, Park HE, Park SA

Primary cardiac tumors are rare, with a prevalence of 0.001–0.2%. Among such tumors, cardiac hemangioendotheliomas are some of the most uncommon. In Korea, there have been no reports of hemangioendothelioma...
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The Different Expression Patterns of HSP22, a Late Embryogenesis Abundant-like Protein, in Hypertrophic H9C2 Cells Induced by NaCl and Angiotensin II

Sung JH, Song A, Park T, Kim E, Lee S

BACKGROUND: High-NaCl diet is a contributing factor for cardiac hypertrophy. The role of HSP22 as a protective protein during cardiac hypertrophy due to hypernatremia is unclear. Accordingly, this study aimed...
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Hemorrhagic pericarditis associated with rivaroxaban in an atrial fibrillation patient with pacemaker

Rhew SH, Kim SS

Rivaroxaban is a new oral anticoagulant used for the prevention of stroke in patients with atrial fibrillation. Hemorrhagic pericarditis is known to occur with rivaroxaban; however, only a few case...
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Canonical Transient Receptor Potential Channels and Their Link with Cardio/Cerebro-Vascular Diseases

Xiao X, Liu HX, Shen K, Cao W, Li XQ

The canonical transient receptor potential channels (TRPCs) constitute a series of nonselective cation channels with variable degrees of Ca2+ selectivity. TRPCs consist of seven mammalian members, TRPC1, TRPC2, TRPC3, TRPC4,...
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Pulmonic stenosis with atrial septal defect in a Siamese cat

Kim JY, Lee SW, Lee SG, Suh SI, Hyun C

A 6-month-old mature intact female Siamese cat presented with exertional dyspnea. Diagnostic studies revealed pleural effusion, grade 4/6 left basal systolic murmur, deep S-wave in electrocardiograph leads I, II, and...
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Zebrafish Larvae Model of Dilated Cardiomyopathy Induced by Terfenadine

Gu G, Na Y, Chung H, Seok SH, Lee HY

BACKGROUND AND OBJECTIVES: Dilated cardiomyopathy can be the end-stage of severe cardiac disorders and directly affects the cardiac muscle, inducing cardiomegaly and heart failure (HF). Although a wide variety of...
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An extremely rare case of prenatally diagnosed absent both aortic and pulmonary valves

Yeon HK, Lee MY, Yoon SY, Jung HJ, Park JE, Shim JY, Won HS, Lee PR, Kim A

We describe a case of absent aortic and pulmonary valves, diagnosed at 16.4 weeks of gestation. Fetal echocardiography showed cardiomegaly with dilated both ventricles. No valve leaflets were observed in...
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Congenital mitral valve stenosis in a Chinchilla cat

Lu TL, Hung YW, Choi R, Hyun C

A one-year-old, 3.25 kg intact male Chinchilla cat presented with acute right hind limb paralysis. Diagnostic imaging studies found cardiomegaly with interstitial lung pattern, abnormal mitral valve leaflets without maximum...
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Fetal Congenital Complete Atrioventricular Block in a Mother with Isolated Serum Anti-SSA/Ro and Anti-SSB/La Antibodies

Mok CW, Park JY, Kim K, Choi SJ, Oh SY, Roh CR, Kim JH

Congenital atrioventricular block (AVB) is rare but carries a significant fetal or neonatal mortality and morbidity. In about half of the cases, it is associated with a congenital structural heart...
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Histone deacetylase inhibitor, CG200745, attenuates cardiac hypertrophy and fibrosis in DOCA-induced hypertensive rats

Lee E, Song MJ, Lee HA, Kang SH, Kim M, Yang EK, Lee DY, Ro S, Cho JM, Kim I

CG200745 is a novel inhibitor of histone deacetylases (HDACs), initially developed for treatment of various hematological and solid cancers. Because it is water-soluble, it can be administered orally. We hypothesized...
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Cardiovascular Adaptation and Side Effects in Middle-Aged Marathoners

Kim YJ

Regular exercise brings about various positive effects on cardiovascular, oncological, psychiatric, neurological, and endocrinological systems of human body. According to exercise types with cardiovascular adaptation, endurance exercise is characterized by...
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Acardiac Twin-Twin Reversed Arterial Perfusion Sequence

Kim SG, Seo HG, Kim YS

In general, twin pregnancy represents a high-risk pregnancy. The monozygous twin of all twin pregnancy is a real challenge for the obstetrician due to the severe complications that may arise...
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Left Ventricular Noncompaction Complicated with Myocardial Infarction with Barth Syndrome in a Newborn

Yoo GH

Left ventricular noncompaction (LVNC) is a rare cardiomyopathy characterized by a hypertrabeculation of the left ventricle. Patients may present with heart failure, arrhythmia, and thromboembolism. LVNC may be isolated or...
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Dilated cardiomyopathy with Graves disease in a young child

Choi YJ, Jang JH, Park SH, Oh JH, Koh DK

Graves disease (GD) can lead to complications such as cardiac arrhythmia and heart failure. Although dilated cardiomyopathy (DCMP) has been occasionally reported in adults with GD, it is rare in...
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Right Coronary Artery to Left Ventricular Fistula with Giant Right Coronary Artery Aneurysm

Kim EY, Park JS, Jeon DS, Jeong SS, Park KJ, Woo JS, Kang EJ

A 35-year-old male with exertional dyspnea was transferred to our hospital for evaluation of a diastolic murmur and cardiomegaly discovered by chest X-ray. Two-dimensional and Doppler echocardiographic studies revealed an...
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A case of prenatally diagnosed extrapulmonary arteriovenous malformation associated with a complex heart defect

Jeong BD, Won HS, An S, Kim JY, Lee MY, Kim EN, Kim JS, Kim CJ

Pulmonary arteriovenous malformations are rare vascular anomalies of the lung, only a few cases of which have been diagnosed prenatally. The diagnostic clue for prenatal diagnosis was cardiomegaly with a...
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cAMP induction by ouabain promotes endothelin-1 secretion via MAPK/ERK signaling in beating rabbit atria

Peng LQ, Li P, Zhang QL, Hong L, Liu LP, Cui X, Cui BR

Adenosine 3',5'-cyclic monophosphate (cAMP) participates in the regulation of numerous cellular functions, including the Na(+)-K(+)-ATPase (sodium pump). Ouabain, used in the treatment of several heart diseases, is known to increase...
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Neuronal nitric oxide synthase in hypertension – an update

Zhang YH

Hypertension is a prevalent condition worldwide and is the key risk factor for fatal cardiovascular complications, such as stroke, sudden cardiac death and heart failure. Reduced bioavailability of nitric oxide...
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EGCG Blocked Phenylephrin-Induced Hypertrophy in H9C2 Cardiomyocytes, by Activating AMPK-Dependent Pathway

Cai Y, Zhao L, Qin Y, Wu XQ

AMP-activated protein kinase (AMPK) is a key regulator of energy metabolism. Previous studies have shown that activation of AMPK results in suppression of cardiac myocyte hypertrophy via inhibition of the...
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