Korean J Anat.
2009 Sep;42(3):141-147.
Streptozotocin-induced Diabetes Increases the Adiponectin-mediated AMP-activated Protein Kinase Cascade in the Hippocampus of Mice
- Affiliations
-
- 1Department of Anatomy and Neurobiology, Institute of Health Sciences, Medical Research Center for Neural Dysfunction, Gyeongsang National University School of Medicine, Jinju, Gyeongnam 660-751, Korea. anaroh@gnu.ac.kr
- 2Department of Internal Medicine, Institute of Health Sciences, Medical Research Center for Neural Dysfunction, Gyeongsang National University School of Medicine, Jinju, Gyeongnam 660-751, Korea.
Abstract
- Adiponectin is an adipocyte-derived protein with anti-diabetic and anti-angiogenesis properties that improves both glucose metabolism and insulin resistance via the adenosine monophosphate-activated protein kinase (AMPK) cascade. Diabetic cognitive deficits are correlated with dysregulation of energy metabolism in the hippocampus. In the present study, we investigated the expression of adiponectin-mediated AMPK cascade proteins in the hippocampus of streptozotocin (STZ)-induced diabetic mice. Diabetes was induced by STZ (55 mg/kg) injection intraperitoneally. Twenty-four weeks after induction of diabetes, mice were sacrificed. Results showed that decreased serum adiponectin levels and increased expression of hippocampal adiponectin receptor 1 (AdipoR1) was expressed in diabetic mice. Phosphorylated AMPK, acetyl CoA carboxylase (ACC), and eNOS expression levels were increased in the hippocampus of diabetic mice. The immunoreactivity of glucose transporter 1 in the endothelium of hippocampal blood vessels was also increased. These results indicate that adiponectin-mediated AMPK cascade activation may play a role in catabolic process that is involved in diabetic neurodegeneration.
Keyword
MeSH Terms
-
Acetyl-CoA Carboxylase
Adenosine
Adiponectin
AMP-Activated Protein Kinases
Animals
Blood Vessels
Endothelium
Energy Metabolism
Glucose
Glucose Transport Proteins, Facilitative
Hippocampus
Insulin Resistance
Mice
Protein Kinases
Proteins
Receptors, Adiponectin
Streptozocin
AMP-Activated Protein Kinases
Acetyl-CoA Carboxylase
Adenosine
Adiponectin
Glucose
Glucose Transport Proteins, Facilitative
Protein Kinases
Proteins
Receptors, Adiponectin
Streptozocin
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