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Longitudinal Changes of High Molecular Weight Adiponectin are Associated with Postpartum Development of Type 2 Diabetes Mellitus in Patients with Gestational Diabetes Mellitus

Lee DH, Lim JA, Kim JH, Kwak SH, Choi SH, Jang HC

Background: The influence of serial changes of adipokines on maternal glucose metabolism from pregnancy to postpartum periods in women with previous gestational diabetes mellitus (pGDM) has not been thoroughly explored....
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Diallyl Biphenyl-Type Neolignans Have a Pharmacophore of PPARα/γ Dual Modulators

Han Y, Liu J, Ahn S, An S, Ko H, Shin JC, Jin SH, Ki MW, Lee SH, Lee KH, Shin SS, Choi WJ, Noh M

Adiponectin secretion-promoting compounds have therapeutic potentials in human metabolic diseases. Diallyl biphenyl-type neolignan compounds, magnolol, honokiol, and 4-O-methylhonokiol, from a Magnolia officinalis extract were screened as adiponectin-secretion promoting compounds in...
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Effect of Weight Reduction on Treatment Outcomes for Patients with Atopic Dermatitis

Jung MJ, Kim HR, Kang SY, Kim HO, Chung BY, Park CW

Background: Several epidemiological studies have shownthat the atopic tendency increases in the obese population. Objective: The aim of this study was to confirm the effect ofweight reduction on improvement of atopic...
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Association between Inflammatory Biomarkers and Nutritional Status in Fatty Liver

Lim HS, Choi J, Lee B, Kim SG, Kim YS, Yoo JJ

The prevalence and progression of non-alcoholic fatty liver disease (NAFLD) is mediated via several factors correlating with hepatic necroinflammation (adipokines/cytokines). This study was performed to analyze the level of inflammatory...
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Serum Adiponectin and Progranulin Level in Patients with Benign Thyroid Nodule or Papillary Thyroid Cancer

Kwon H, Park SE, Yun JS, Park CY

Background: Obesity is associated with thyroid cancer risk. Adiponectin has insulin-sensitizing and anti-inflammatory effects, while progranulin is associated with inflammation and tumorigenesis. We investigated serum adiponectin and progranulin levels in...
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Serum adipocytokines and adiposity as predictive indices of preeclampsia

Bawah AT, Yeboah FA, Nanga S, Alidu H, Ngala RA

Background This study was aimed at determining the levels of serum adiponectin, leptin, resistin, visfatin and lipids during the first trimester in pregnant women and to evaluate the relationship between these...
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Cut-off Values and Clinical Utility of Surrogate Markers for Insulin Resistance and Beta-Cell Function to Identify Metabolic Syndrome and Its Components among Southern Indian Adults

Endukuru CK, Gaur GS, Yerrabelli D, Sahoo J, Vairappan B

Background: Insulin resistance (IR) is a collective clinical entity that exacerbates metabolic syndrome (MetS). As the gold-standard test to quantify IR involves intravenous insulin loading and repeated blood glucose monitoring, many...
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Blood level of adipokines and nutritional status variables in adolescent pregnancy

Fernandes MD, Daher S, de Sousa LM, Baratto I, Lobo TF, Araujo Júnior E, Guazzelli CAF

Objective To evaluate the serum levels of adiponectin and leptin and their relationship with nutritional variables during pregnancy in adolescents. Methods This prospective cohort study evaluated eutrophic pregnant adolescents (body mass...
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Role of Soluble Adiponectin Receptor 2 in Non-Alcoholic Fatty Liver Disease in Children

Aksoy GK, Artan R, Aksoy C, Özdem S, Atalay A, Yılmaz A

PURPOSE: The incidence of non-alcoholic fatty liver disease (NAFLD) in children is gradually increasing. The aim of this study was to investigate the use of serum adiponectin and soluble adiponectin...
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Mitochondrial Dysfunction in Adipocytes as a Primary Cause of Adipose Tissue Inflammation

Woo CY, Jang JE, Lee SE, Koh EH, Lee KU

Adipose tissue inflammation is considered a major contributing factor in the development of obesity-associated insulin resistance and cardiovascular diseases. However, the cause of adipose tissue inflammation is presently unclear. The...
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Adiponectin for the treatment of diabetic nephropathy

Lee JY, Yang JW, Han BG, Choi SO, Kim JS

The metabolic burden caused by hyperglycemia can result in direct and immediate metabolic injuries, such as oxidative stress and tissue inflammation, in the kidney. Furthermore, chronic hyperglycemia can lead to...
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Daily walnut intake improves metabolic syndrome status and increases circulating adiponectin levels: randomized controlled crossover trial

Hwang HJ, Liu Y, Kim HS, Lee H, Lim Y, Park H

BACKGROUND/OBJECTIVES: Several previous studies have investigated whether regular walnut consumption positively changes heart-health-related parameters. The aim of this study was to investigate the effects of daily walnut intake on metabolic...
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Adiponectin Attenuates the Inflammation in Atopic Dermatitis-Like Reconstructed Human Epidermis

Seo HS, Seong KH, Kim CD, Seo SJ, Park BC, Kim MH, Hong SP

BACKGROUND: Atopic dermatitis (AD) is a chronic disorder, with a vicious cycle of repetitive inflammation and deterioration of the epidermal barrier function. Adiponectin, an adipokine, has anti-inflammatory effects on various...
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Insulin Resistance Is Associated with Early Gastric Cancer: A Prospective Multicenter Case Control Study

Kwon HJ, Park MI, Park SJ, Moon W, Kim SE, Kim JH, Choi YJ, Lee SK

BACKGROUND/AIMS: Recently, increased body weight has been found to be associated with an increasing risk of several cancers, including gastric cancer. The true pathogenic role of hyperglycemia in the development...
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Autumn olive (Elaeagnus umbellata Thunb.) berry reduces fasting and postprandial glucose levels in mice

Kim JI, Baek HJ, Han DW, Yun JA

BACKGROUND/OBJECTIVES: Fasting and postprandial hyperglycemia should be controlled to avoid complications of diabetes mellitus. This study investigated the effects of autumn olive (Elaeagnus umbellata Thunb.) berry (AOB) on fasting and...
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The Association of Adiponectin and Visceral Fat with Insulin Resistance and β-Cell Dysfunction

Moon HU, Ha KH, Han SJ, Kim HJ, Kim DJ

BACKGROUND: Obesity is a risk factor for metabolic abnormalities. We investigated the relationship of adiponectin levels and visceral adiposity with insulin resistance and β-cell dysfunction. METHODS: This cross-sectional study enrolled 1,347...
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Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients

Nam JS, Han JW, Lee SB, You JH, Kim MJ, Kang S, Park JS, Ahn CW

BACKGROUND: Genetic variations in calpain-10 and adiponectin gene are known to influence insulin secretion and resistance in type 2 diabetes mellitus. Recently, several single nucleotide polymorphisms (SNPs) in calpain-10 and...
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ZFP36L1 and AUF1 Induction Contribute to the Suppression of Inflammatory Mediators Expression by Globular Adiponectin via Autophagy Induction in Macrophages

Shrestha A, Pun NT, Park PH

Adiponectin, a hormone predominantly originated from adipose tissue, has exhibited potent anti-inflammatory properties. Accumulating evidence suggests that autophagy induction plays a crucial role in anti-inflammatory responses by adiponectin. However, underlying...
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Association of Adiponectin 45T/G Polymorphism with Diabetic Cardiovascular Complications in Korean Type 2 Diabetes

Ji MJ, Ku EJ, Oh TK, Jeon HJ

BACKGROUND: Adiponectin is an adipokine that regulates lipid and glucose metabolism and has been shown to have anti-inflammatory and anti-atherogenic effects. It also plays an important role in the development...
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Lower Levels of Serum Adiponectin and the T Allele of rs1501299 of the ADIPOQ Gene Are Protective against Polycystic Ovarian Syndrome in Jordan

Alfaqih MA, Khader YS, Al-Dwairi , Alzoubi A, Al-Shboul , Hatim A

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common reproductive disorder. Obesity, which is linked with lower adiponectin levels, increases a woman's risk of developing PCOS; however, the association between adiponectin...
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