- Quercetin-induced apoptosis ameliorates vascular smooth muscle cell senescence through AMP-activated protein kinase signaling pathway
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Kim SG, Sung JY, Kim JR, Choi HC
- KMID: 2466571
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):69-79.
- doi: 10.4196/kjpp.2020.24.1.69
Aging is one of the risk factors for the development of cardiovascular diseases. During the progression of cellular senescence, cells enter a state of irreversible growth arrest and display resistance... -
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- Medium- and long-chain triglyceride propofol reduces the activity of acetyl-coenzyme A carboxylase in hepatic lipid metabolism in HepG2 and Huh7 cells
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Wang LY, Wu J, Gao YF, Lin DM, Ma J
- KMID: 2466566
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):19-26.
- doi: 10.4196/kjpp.2020.24.1.19
Medium- and long-chain triglyceride (MCT/LCT) propofol is widely used as an intravenous anesthetic, especially in the intensive care unit. The present study aimed to assess whether MCT/LCT propofol is safe... -
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- Asiatic Acid Induces Apoptosis and Autophagy and Reduces MiR-17 and MiR-21 Expression in Pancreatic Cancer Cell Lines
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Jo YG, Kim M, Shin H, Lee KY, Lee EJ
- KMID: 2468062
- Nat Prod Sci.
- 2019 Dec;25(4):298-303.
- doi: 10.20307/nps.2019.25.4.298
This study investigated the cytotoxic effects and mechanism of action of asiatic acid in pancreatic cancer cell lines. First, we confirmed the cell viability of MIA PaCa-2 and PANC-1 cells... -
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- Metformin Ameliorates Lipotoxic β-Cell Dysfunction through a Concentration-Dependent Dual Mechanism of Action
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Kim HI, Lee JS, Kwak BK, Hwang WM, Kim MJ, Kim YB, Chung SS, Park KS
- KMID: 2466506
- Diabetes Metab J.
- 2019 Dec;43(6):854-866.
- doi: 10.4093/dmj.2018.0179
BACKGROUND: Chronic exposure to elevated levels of free fatty acids contributes to pancreatic β-cell dysfunction. Although it is well known that metformin induces cellular energy depletion and a concomitant activation... -
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- ¹H-NMR Analysis of Metabolic Changes Induced by Snf1/AMP-Activated Protein Kinase During Environmental Stress Responses
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Kim J, Oh J, Yoon DH, Sung GH
- KMID: 2470147
- Mycobiology.
- 2019 Sep;47(3):346-349.
- doi: 10.1080/12298093.2019.1625854
AMP-activated protein kinase sucrose non-fermenting 1 (Snf1) is a representative regulator of energy status that maintains cellular energy homeostasis. In addition, Snf1 is involved in the mediation of environmental stress... -
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- Anti-malarial Drugs Reduce Vascular Smooth Muscle Cell Proliferation via Activation of AMPK and Inhibition of Smad3 Signaling
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Lee H, Han JH, Kim S, Kim S, Cho DH, Woo CH
- KMID: 2458392
- J Lipid Atheroscler.
- 2019 Sep;8(2):267-276.
- doi: 10.12997/jla.2019.8.2.267
OBJECTIVE: The aim of this study was to investigate the effects of 2 anti-malarial drugs, chloroquine (CQ) and hydroxychloroquine (HCQ), on inhibition of vascular smooth muscle cell (VSMC) proliferation both... -
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- Humanin suppresses receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation via AMP-activated protein kinase activation
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Kang N, Kim KW, Shin DM
- KMID: 2455817
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):411-417.
- doi: 10.4196/kjpp.2019.23.5.411
Humanin (HN) is a mitochondrial peptide that exhibits cytoprotective actions against various stresses and diseases. HN has been shown to induce the phosphorylation of AMP-activated protein kinase (AMPK), which is... -
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- KIF11 Functions as an Oncogene and Is Associated with Poor Outcomes from Breast Cancer
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Zhou J, Chen WR, Yang LC, Wang J, Sun JY, Zhang WW, He ZY, Wu SG
- KMID: 2454312
- Cancer Res Treat.
- 2019 Jul;51(3):1207-1221.
- doi: 10.4143/crt.2018.460
PURPOSE: The study aimed to search and identify genes that were differentially expressed in breast cancer, and their roles in cancer growth and progression. MATERIALS AND METHODS: The Gene Expression Omnibus... -
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- Effect of Manuka Honey on Transforming Growth Factor Beta-1-Induced Extracelluar Matrix Production in Nasal Polyp Derived Fibroblasts
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Kil BK, Kim BM, Kang BJ, Ye MK, Shin SH
- KMID: 2451614
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2019 Jun;62(6):336-342.
- doi: 10.3342/kjorl-hns.2018.00682
BACKGROUND AND OBJECTIVES: Manuka honey has anti-microbial, anti-inflammatory, and anti-proliferative action with a high concentration of methylglyoxal compound. It is also effective in killing Staphylococcus aureus biofilm and effective for... -
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- Metformin, an Activator of AMPK, Promotes the Growth of Hair Follicles via the AMPK/β-catenin Signaling Pathway
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Moon HR, Park KY, Kang HJ, Lee WJ, Won CH, Chang SE, Lee MW, Choi JH, Park GH
- KMID: 2449198
- Korean J Dermatol.
- 2019 May;57(4):175-181.
BACKGROUND: AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that plays a pivotal role in the balance of cellular energy metabolism. Recent studies have reported that AMPK has numerous... -
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- Metabolic Reprogramming by the Excessive AMPK Activation Exacerbates Antigen-Specific Memory CD8⺠T Cell Differentiation after Acute Lymphocytic Choriomeningitis Virus Infection
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Son J, Cho YW, Woo YJ, Baek YA, Kim EJ, Cho Y, Kim JY, Kim BS, Song JJ, Ha SJ
- KMID: 2444159
- Immune Netw.
- 2019 Apr;19(2):e11.
- doi: 10.4110/in.2019.19.e11
During virus infection, T cells must be adapted to activation and lineage differentiation states via metabolic reprogramming. Whereas effector CD8⺠T cells preferentially use glycolysis for their rapid proliferation, memory... -
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- Red pepper seed water extract inhibits preadipocyte differentiation and induces mature adipocyte apoptosis in 3T3-L1 cells
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Kim HJ, You MK, Lee YH, Kim HJ, Adhikari D, Kim HA
- KMID: 2448694
- Nutr Res Pract.
- 2018 Dec;12(6):494-502.
- doi: 10.4162/nrp.2018.12.6.494
BACKGROUND/OBJECTIVES: Reducing the number of adipocytes by inducing apoptosis of mature adipocytes as well as suppressing differentiation of preadipocytes plays an important role in preventing obesity. This study examines the... -
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- Quercetin induces cell death in cervical cancer by reducing O-GlcNAcylation of adenosine monophosphate-activated protein kinase
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Ali A, Kim MJ, Kim MY, Lee HJ, Roh GS, Kim HJ, Cho GJ, Choi WS
- KMID: 2430195
- Anat Cell Biol.
- 2018 Dec;51(4):274-283.
- doi: 10.5115/acb.2018.51.4.274
Hyper-O-GlcNAcylation is a general feature of cancer which contributes to various cancer phenotypes, including cell proliferation and cell growth. Quercetin, a naturally occurring dietary flavonoid, has been reported to reduce... -
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- High-Dose Metformin Plus Temozolomide Shows Increased Anti-tumor Effects in Glioblastoma In Vitro and In vivo Compared with Monotherapy
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Lee JE, Lim JH, Hong YK, Yang SH
- KMID: 2424805
- Cancer Res Treat.
- 2018 Oct;50(4):1331-1342.
- doi: 10.4143/crt.2017.466
PURPOSE: The purpose of the study is to investigate the efficacy of combined treatment with temozolomide (TMZ) and metformin for glioblastoma (GBM) in Vitro and in vivo. MATERIALS AND METHODS: We... -
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- The Novel Neuroprotective Compound KMS99220 Has an Early Anti-neuroinflammatory Effect via AMPK and HO-1, Independent of Nrf2
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Lee JA, Kim HR, Kim J, Park KD, Kim DJ, Hwang O
- KMID: 2424735
- Exp Neurobiol.
- 2018 Oct;27(5):408-418.
- doi: 10.5607/en.2018.27.5.408
We have previously reported a novel synthetic compound KMS99220 that prevented degeneration of the nigral dopaminergic neurons and the associated motor deficits, suggesting a neuroprotective therapeutic utility for Parkinson's disease.... -
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- Anti-proliferative Effect of 15,16-Dihydrotanshinone I Through Cell Cycle Arrest and the Regulation of AMP-activated Protein Kinase/Akt/mTOR and Mitogen-activated Protein Kinase Signaling Pathway in Human Hepatocellular Carcinoma Cells
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Hong JY, Park SH, Park HJ, Lee SK
- KMID: 2417368
- J Cancer Prev.
- 2018 Jun;23(2):63-69.
- doi: 10.15430/JCP.2018.23.2.63
BACKGROUND: 15,16-dihydrotanshinone I (DHTS) is a natural abietane diterpenoid that is mainly found in the roots of Salvia miltiorrhiza Bunge (Labiatae). DHTS exhibits a potential anti-proliferative effect in various human... -
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- Quercetin Upregulates Uncoupling Protein 1 in White/Brown Adipose Tissues through Sympathetic Stimulation
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Choi H, Kim CS, Yu R
- KMID: 2415627
- J Obes Metab Syndr.
- 2018 Jun;27(2):102-109.
- doi: 10.7570/jomes.2018.27.2.102
BACKGROUND: Uncoupling protein 1 (UCP1) plays an important role in increasing energy expenditure; thus, it is being considered as a new target for preventing obesity and metabolic complications. In this... -
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- Compound K attenuates glucose intolerance and hepatic steatosis through AMPK-dependent pathways in type 2 diabetic OLETF rats
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Hwang YC, Oh DH, Choi MC, Lee SY, Ahn KJ, Chung HY, Lim SJ, Chung SH, Jeong IK
- KMID: 2411547
- Korean J Intern Med.
- 2018 Mar;33(2):347-355.
- doi: 10.3904/kjim.2015.208
BACKGROUND/AIMS: Non-alcoholic fatty liver disease is associated with insulin resistance. Compound K (CK) is the final metabolite of panaxadiol ginsenosides that have been shown to exert antidiabetic effects. However, the... -
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- Anti-hyperglycemic effects and signaling mechanism of Perilla frutescens sprout extract
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Kim DH, Kim SJ, Yu KY, Jeong SI, Kim SY
- KMID: 2429015
- Nutr Res Pract.
- 2018 Feb;12(1):20-28.
- doi: 10.4162/nrp.2018.12.1.20
BACKGROUND/OBJECTIVES: Perilla frutescens (L.) Britton var. (PF) sprout is a plant of the labiate family. We have previously reported the protective effects of PF sprout extract on cytokine-induced β-cell damage.... -
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- The Improving Effect of HL271, a Chemical Derivative of Metformin, a Popular Drug for Type II Diabetes Mellitus, on Aging-induced Cognitive Decline
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Bang E, Lee B, Park JO, Jang Y, Kim A, Kim S, Shin HS
- KMID: 2405308
- Exp Neurobiol.
- 2018 Feb;27(1):45-56.
- doi: 10.5607/en.2018.27.1.45
In recent years, as the aging population grows, aging-induced cognitive impairments including dementia and Alzheimer's disease (AD) have become the biggest challenges for global public health and social care. Therefore,... -
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