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Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus in Korea: High Rate of False Resistance to Linezolid by the VITEK 2 System

Yoo IY, Kang OK, Shim HJ, Huh HJ, Lee NY

As various linezolid resistance mechanisms have been identified in methicillin-resistant Staphylococcus aureus (MRSA), we investigated the molecular characteristics of MRSA with elevated linezolid minimum inhibitory concentrations (MICs), using the VITEK...
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Molecular Epidemiology and Mechanisms of 43 Low-Level Linezolid-Resistant Enterococcus faecalis Strains in Chongqing, China

Hua R, Xia Y, Wu W, Yang M, Yan J

BACKGROUND: Enterococcus faecalis strains with low-level resistance to linezolid (an oxazolidinone antibiotic) have become common. No large-scale study has examined the underlying mechanisms in linezolid-resistant E. faecalis (LRE) strains. We...
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Omadacycline, a Magic Antibiotics for Bacterial Infections

Rahman MS, Koh YS

Nowadays antibiotic resistance is a worldwide serious problem that mainly affects public health. Omadacycline is a unique antibiotic which has two available dosage forms such as intravenous (IV) and oral...
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RPS15a Silencing Suppresses Cell Proliferation and Migration of Gastric Cancer

Shi D, Liu J

PURPOSE: Information on the possible role of the ribosomal protein S15a (RPS15a) in gastric cancer is scarce. The aim of this study was to evaluate the impact of RPS15a gene...
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RNF138-mediated ubiquitination of rpS3 is required for resistance of glioblastoma cells to radiation-induced apoptosis

Kim W, Youn H, Lee S, Kim E, Kim D, Sub Lee J, Lee JM, Youn B

An interaction between ribosomal protein S3 (rpS3) and nuclear factor kappa B or macrophage migration inhibitory factor in non-small-cell lung cancer is responsible for radioresistance. However, the role of rpS3...
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Diverse Immunoprofile of Ductal Adenocarcinoma of the Prostate with an Emphasis on the Prognostic Factors

Jeong SU, Kekatpure , Park JM, Han M, Hwang HS, Jeong HJ, Go H, Cho YM

BACKGROUND: Ductal adenocarcinoma (DAC) of the prostate is an uncommon histologic subtype whose prognostic factors and immunoprofile have not been fully defined. METHODS: To define its prognostic factors and immunoprofile, the...
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Differential Protein Expressions in Virus-Infected and Uninfected Trichomonas vaginalis

He D, Pengtao G, Ju Y, Jianhua L, He L, Guocai Z, Xichen Z

Protozoan viruses may influence the function and pathogenicity of the protozoa. Trichomonas vaginalis is a parasitic protozoan that could contain a double stranded RNA (dsRNA) virus, T. vaginalis virus (TVV)....
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Molecular cloning and characterization of porcine ribosomal protein L21

Sun WS, Chun JL, Kim DH, Ahn JS, Kim MK, Hwang IS, Kwon DJ, Hwang S, Lee JW

Ribosomal protein L21 (RPL21) is a structural component of the 60S subunit of the eukaryotic ribosome. This protein has an important role in protein synthesis and the occurrence of hereditary...
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Imaging Mass Spectrometry in Papillary Thyroid Carcinoma for the Identification and Validation of Biomarker Proteins

Min KW, Bang JY, Kim KP, Kim WS, Lee SH, Shanta SR, Lee JH, Hong JH, Lim SD, Yoo YB, Na CH

Direct tissue imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization and time-of-flight (MALDI-TOF) mass spectrometry has become increasingly important in biology and medicine, because this technology can detect the...
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Ribosomal protein mutations in Korean patients with Diamond-Blackfan anemia

Chae H, Park J, Lee S, Kim M, Kim Y, Lee JW, Chung NG, Cho B, Jeong DC, Kim J, Kim JR, Park G

Diamond-Blackfan anemia (DBA) is a congenital bone marrow failure syndrome characterized by hypoproliferative anemia, associated physical malformations and a predisposition to cancer. DBA has been associated with mutations and deletions...
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Expression and Characterization of Genes by Expressed Sequence Tag Analysis in the Rat Thymus during Regeneration following Acute Thymic Involution Induced by Cyclophosphamide

Lee KH, Lee HW, Choi HJ, Min HJ, Baek SY, Yoon S

The thymus is the central lymphoid organ for the development of bone marrow-derived precursor cells into mature T-cells. Understanding the molecular mechanism of thymic involution and regeneration is critical to...
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Neuroprotective Effect of Rapamycin in Optic Nerve Transection Model

Kim SH, Han YK, Park KH, Kim YJ

PURPOSE: The present study investigated whether rapamycin activated autophagy in retinal ganglion cells (RGC) and evaluated its effect on RGC survival following optic nerve transection (ONT). METHODS: The activation of autophagy...
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Diagnosis of canine brucellosis using recombinant ribosomal protein L7/L12

Lee HK, Kim JW, Ha YM, Her M, Kim JY, Lee K, Kang SI, Jung SC

  • KMID: 1435796
  • Korean J Vet Res.
  • 2012 Mar;52(1):25-31.
Brucella (B.) canis is mainly transmitted by direct or indirect contact with aborted fetuses and placenta. It's also known to be able to infect human, which likely results in providing...
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Gene expression profile analysis of xylitol-sensitive and xylitol-resistant Streptococcus mutans in 0.5% glucose containing TYE media using DNA chip

Im SU, Ahn SH, Park DO, Choi YH, Song KB

  • KMID: 2321390
  • J Korean Acad Oral Health.
  • 2012 Dec;36(4):251-265.
OBJECTIVES: Streptococcus mutans (S. mutans) is the major causative bacteria in dental caries. Xylitol is an effective anticarious natural sugar substitute by inhibiting the virulence of S. mutans. However, long-term...
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Ribosomal Protein L19 and L22 Modulate TLR3 Signaling

Yang EJ, Seo JW, Choi IH

BACKGROUND: Toll-like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA) and induces inflammation. In this study we attempted to ascertain if there are endogenous host molecules controlling the production of cytokines...
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Diamond-Blackfan Anemia Confirmed by RPS19 Gene Mutation Analysis: A Case Study and Literature Review of Korean Patients

Chae H, Park J, Kim M, Lim J, Kim Y, Han K, Lee J, Chung NG, Cho B, Kim HK

Diamond-Blackfan anemia (DBA) is a rare congenital erythroid hypoplastic anemia that usually presents early in infancy and is inherited in up to 45% of cases. It is characterized by red...
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Analysis of Low Molecular Weight Proteome from H. pylori Cell Extract Using the High Performance Liquid Chromatography

Park JW, Lee KJ, Kim KM, Joo JS, Kwon YC, Youn HS, Song JY, Kang HL, Lee KH, Baik SC, Lee WK, Cho MJ, Rhee KH

Low molecular proteins (LMPs) which are smaller than 20 kDa are difficult to visible on a standard two-dimensional SDS-polyacrylamide gel electrophoresis (2-D SDS-PAGE) map. LMPs must be enriched appropriately to...
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Detection of genetic mutations associated with macrolide resistance of Mycoplasma pneumoniae

Oh CE, Choi EH, Lee HJ

PURPOSE: The aim of this study was to identify mutations associated with macrolide resistance in Mycoplasma pneumoniae (MP) and to establish a cultural method to determine antimicrobial susceptibility. METHODS: Nasopharyngeal aspirates...
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Identification of Differentially Expressed Genes in Bovine Follicular Cystic Ovaries

Choe C, Cho YW, Kim CW, Son DS, Han J, Kang D

Follicular cystic ovary (FCO) is one of the most frequently diagnosed ovarian diseases and is a major cause of reproductive failure in mammalian species. However, the mechanism by which FCO...
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Altered Gene Expression in Cerulein-Stimulated Pancreatic Acinar Cells: Pathologic Mechanism of Acute Pancreatitis

Yu JH, Lim JW, Kim H

Acute pancreatitis is a multifactorial disease associated with the premature activation of digestive enzymes. The genes expressed in pancreatic acinar cells determine the severity of the disease. The present study...
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