- Generation of Multilayered 3D Structures of HepG2 Cells Using a Bio-printing Technique
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Jeon H, Kang K, Park SA, Kim WD, Paik SS, Lee SH, Jeong J, Choi D
- KMID: 2412163
- Gut Liver.
- 2017 Jan;11(1):121-128.
- doi: 10.5009/gnl16010
BACKGROUND/AIMS: Chronic liver disease is a major widespread cause of death, and whole liver transplantation is the only definitive treatment for patients with end-stage liver diseases. However, many problems, including... -
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- miR-379 Inhibits Cell Proliferation, Invasion, and Migration of Vascular Smooth Muscle Cells by Targeting Insulin-Like Factor-1
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Li K, Wang Y, Zhang A, Liu B, Jia L
- KMID: 2374211
- Yonsei Med J.
- 2017 Jan;58(1):234-240.
- doi: 10.3349/ymj.2017.58.1.234
PURPOSE: MicroRNAs are small non-coding RNAs that play important roles in vascular smooth muscle cell (VSMC) function. This study investigated the role of miR-379 on proliferation, invasion, and migration of... -
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- Metformin Reduces Bleomycin-induced Pulmonary Fibrosis in Mice
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Choi SM, Jang AH, Kim H, Lee KH, Kim YW
- KMID: 2468274
- J Korean Med Sci.
- 2016 Sep;31(9):1419-1425.
- doi: 10.3346/jkms.2016.31.9.1419
Metformin has anti-inflammatory and anti-fibrotic effects. We investigated whether metformin has an inhibitory effect on bleomycin (BLM)-induced pulmonary fibrosis in a murine model. A total of 62 mice were divided... -
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- Metabolic Pathway Signatures Associated with Urinary Metabolite Biomarkers Differentiate Bladder Cancer Patients from Healthy Controls
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Kim WT, Yun SJ, Yan C, Jeong P, Kim YH, Lee IS, Kang HW, Park S, Moon SK, Choi YH, Choi YD, Kim IY, Kim J, Kim WJ
- KMID: 2374116
- Yonsei Med J.
- 2016 Jul;57(4):865-871.
- doi: 10.3349/ymj.2016.57.4.865
PURPOSE: Our previous high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry study identified bladder cancer (BCA)-specific urine metabolites, including carnitine, acylcarnitines, and melatonin. The objective of the current study was to determine... -
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- Tryptase and Protease-Activated Receptor 2 Expression Levels in Irritable Bowel Syndrome
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Liang WJ, Zhang G, Luo HS, Liang LX, Huang D, Zhang FC
- KMID: 2411965
- Gut Liver.
- 2016 May;10(3):382-390.
- doi: 10.5009/gnl14319
BACKGROUND/AIMS: Previous studies have revealed that mast cells (MCs) may activate the protease-activated receptors and release of neuropeptides involved in the pathogenesis of irritable bowel syndrome (IBS). The levels of... -
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- STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin M through Induction of Matrix Metalloproteinases 2 and 9
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Ko HS, Park BJ, Choi SK, Kang HK, Kim A, Kim HS, Park IY, Shin JC
- KMID: 2374099
- Yonsei Med J.
- 2016 May;57(3):761-768.
- doi: 10.3349/ymj.2016.57.3.761
PURPOSE: Our previous studies have shown that oncostatin M (OSM) promotes trophoblast invasion activity through increased enzyme activity of matrix metalloproteinase (MMP)-2 and -9. We further investigated OSM-induced intracellular signaling... -
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- The Glucotoxicity Protecting Effect of Ezetimibe in Pancreatic Beta Cells via Inhibition of CD36
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Yoon JS, Moon JS, Kim YW, Won KC, Lee HW
- KMID: 2363693
- J Korean Med Sci.
- 2016 Apr;31(4):547-552.
- doi: 10.3346/jkms.2016.31.4.547
Inhibition of CD36, a fatty acid transporter, has been reported to prevent glucotoxicity and ameliorate high glucose induced beta cell dysfunction. Ezetimibe is a selective cholesterol absorption inhibitor that blocks... -
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- The effects of nonyl phenoxypolyethoxyl ethanol on cell damage pathway gene expression in SK-NSH cells
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Park S, Hwang IW, Kim JS, Kang HC, Park SY, Gil HW, Song HY, Hong SY
- KMID: 2381592
- Korean J Intern Med.
- 2015 Nov;30(6):873-883.
- doi: 10.3904/kjim.2015.30.6.873
BACKGROUND/AIMS: Most pesticide formulations contain both chief and additive ingredients. But, the additives may not have been tested as thoroughly as the chief ingredients. The surfactant, nonyl phenoxypolyethoxylethanol (NP40), is... -
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- Jak1/Stat3 Is an Upstream Signaling of NF-kappaB Activation in Helicobacter pylori-Induced IL-8 Production in Gastric Epithelial AGS Cells
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Cha B, Lim JW, Kim H
- KMID: 2450365
- Yonsei Med J.
- 2015 May;56(3):862-866.
- doi: 10.3349/ymj.2015.56.3.862
Helicobacter pylori (H. pylori) induces the activation of nuclear factor-kB (NF-kappaB) and cytokine expression in gastric epithelial cells. The Janus kinase/signal transducers and activators of transcription (Jak/Stat) cascade is the... -
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- Pyrrolidine Dithiocarbamate Inhibits Nuclear Factor kappaB and Toll-Like Receptor 4 Expression in Rats with Acute Necrotizing Pancreatitis
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Xu M, Wang KN, Wu K, Wang XP
- KMID: 2155650
- Gut Liver.
- 2015 May;9(3):411-416.
- doi: 10.5009/gnl14050
BACKGROUND/AIMS: To investigate the expression of Toll-like receptor 4 (TLR4) in the pancreases of rats with acute necrotizing pancreatitis (ANP) and any changes upon treatment with pyrrolidine dithiocarbamate (PDTC), an... -
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- Nucleotide Binding Oligomerization Domain 1 Is an Essential Signal Transducer in Human Epithelial Cells Infected with Helicobacter pylori That Induces the Transepithelial Migration of Neutrophils
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Kim BJ, Kim JY, Hwang ES, Kim JG
- KMID: 2155644
- Gut Liver.
- 2015 May;9(3):358-369.
- doi: 10.5009/gnl13218
BACKGROUND/AIMS: The cytosolic host protein nucleotide binding oligomerization domain 1 (Nod1) has emerged as a key pathogen recognition molecule for innate immune responses in epithelial cells. The purpose of the... -
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- Expression of Peroxisome Proliferato Activated Receptor gamma in Prostatic Adenocarcinoma
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Park HK, Kim H, Kim HG, Cho YM, Jung WY, Han HS, Hwang TS, Kwon GY, Lim SD
- KMID: 2155464
- J Korean Med Sci.
- 2015 May;30(5):533-541.
- doi: 10.3346/jkms.2015.30.5.533
Peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor has been investigated as the target for cancer treatment as well as metabolic disorders. Recent studies have demonstrated that PPAR-gamma ligands... -
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- DNA Hypomethylation-Mediated Overexpression of Carbonic Anhydrase 9 Induces an Aggressive Phenotype in Ovarian Cancer Cells
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Sung HY, Ju W, Ahn JH
- KMID: 2070216
- Yonsei Med J.
- 2014 Nov;55(6):1656-1663.
- doi: 10.3349/ymj.2014.55.6.1656
PURPOSE: Both genetic and epigenetic alterations can lead to abnormal expression of metastasis-regulating genes in tumor cells. Recent studies suggest that aberrant epigenetic alterations, followed by differential gene expression, leads... -
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- Knockdown of Bcl-xL Enhances Growth-Inhibiting and Apoptosis-Inducing Effects of Resveratrol and Clofarabine in Malignant Mesothelioma H-2452 Cells
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Lee YJ, Hwang IS, Lee YJ, Lee CH, Kim SH, Nam HS, Choi YJ, Lee SH
- KMID: 2069926
- J Korean Med Sci.
- 2014 Nov;29(11):1464-1472.
- doi: 10.3346/jkms.2014.29.11.1464
Mcl-1 and Bcl-xL, key anti-apoptotic proteins of the Bcl-2 family, have attracted attention as important molecules in the cell survival and drug resistance. In this study, we investigated whether inhibition... -
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- Overexpression of Mucin 13 due to Promoter Methylation Promotes Aggressive Behavior in Ovarian Cancer Cells
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Sung HY, Park AK, Ju W, Ahn JH
- KMID: 1799482
- Yonsei Med J.
- 2014 Sep;55(5):1206-1213.
- doi: 10.3349/ymj.2014.55.5.1206
PURPOSE: Recent discoveries suggest that aberrant DNA methylation provides cancer cells with advanced metastatic properties. However, the precise regulatory mechanisms controlling metastasis genes and their role in metastatic transformation are... -
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- LRIG1 Enhances Chemosensitivity by Modulating BCL-2 Expression and Receptor Tyrosine Kinase Signaling in Glioma Cells
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Guo Z, Chen Q, Liu B, Tian D, Zhang S, Li M
- KMID: 1799481
- Yonsei Med J.
- 2014 Sep;55(5):1196-1205.
- doi: 10.3349/ymj.2014.55.5.1196
PURPOSE: Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) are an inhibitor of receptor tyrosine kinases (RTKs) that was discovered in recent years, and many studies showed that LRIG1 is a... -
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- 2,3,7,8-Tetrachlorodibenzo-P-Dioxin Induced Cell-Specific Drug Transporters With Acquired Cisplatin Resistance in Cisplatin Sensitive Cancer Cells
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Gotovdorj , Lee E, Lim Y, Cha EJ, Kwon D, Hong E, Kim Y, Oh MY
- KMID: 1794595
- J Korean Med Sci.
- 2014 Sep;29(9):1188-1198.
- doi: 10.3346/jkms.2014.29.9.1188
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can induce drug transporter genes such as the ATP-binding cassette G member 2 (ABCG2), which contributes to multidrug resistance. We investigated the effect of TCDD pretreatment on drug... -
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- CD64 Expression Is Increased in Patients with Severe Acute Pancreatitis: Clinical Significance
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Zhang H, Ling XL, Wu YY, Lu MH, Guo H, Zhang PB, Zhao XY, Yang SM
- KMID: 1792370
- Gut Liver.
- 2014 Jul;8(4):445-451.
BACKGROUND/AIMS: Upregulated CD64 expression on neutrophils is the most useful marker for acute bacterial infections and systemic inflammation. However, it is unknown whether CD64 is involved in the pathogenesis of... -
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- Effect of Macrophage Migration Inhibitory Factor on Corneal Sensitivity after Laser In Situ Keratomileusis in Rabbit
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Hyon JY, Hose S, Gongora C, Sinha D, O'Brien T
- KMID: 1792112
- Korean J Ophthalmol.
- 2014 Apr;28(2):170-176.
- doi: 10.3341/kjo.2014.28.2.170
PURPOSE: To investigate the effect of macrophage migration inhibitory factor (MIF) on corneal sensitivity after laser in situ keratomileusis (LASIK) surgery. METHODS: New Zealand white rabbits were used in this study.... -
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- Growth Inhibition of Hepatocellular Carcinoma Huh7 Cells by Lactobacillus casei Extract
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Han DJ, Kim JB, Park SY, Yang MG, Kim H
- KMID: 1793166
- Yonsei Med J.
- 2013 Sep;54(5):1186-1193.
- doi: 10.3349/ymj.2013.54.5.1186
PURPOSE: Lactobacillus casei (L. casei) is known to exert anti-proliferation effects on many types of cancer cells. However, the effect of L. casei on liver cancer has not been reported.... -
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